Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Jennifer K. Lodge"'
Autor:
Charles A. Specht, Ruiying Wang, Lorena V. N. Oliveira, Maureen M. Hester, Christina Gomez, Zhongming Mou, Diana Carlson, Chrono K. Lee, Camaron R. Hole, Woei C. Lam, Rajendra Upadhya, Jennifer K. Lodge, Stuart M. Levitz
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT The global burden of infections due to the pathogenic fungus Cryptococcus is substantial in persons with low CD4+ T-cell counts. Previously, we deleted three chitin deacetylase genes from Cryptococcus neoformans to create a chitosan-deficien
Externí odkaz:
https://doaj.org/article/06a1bf7a6e2243f584d221896bb3e019
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cryptococcus neoformans and C. gattii, the etiologic agents of cryptococcosis, cause over 100,000 deaths worldwide every year, yet no cryptococcal vaccine has progressed to clinical trials. In preclinical studies, mice vaccinated with an attenuated s
Externí odkaz:
https://doaj.org/article/cd822e4aaf3044ae875264ba6359ba7b
Publikováno v:
Frontiers in Fungal Biology, Vol 4 (2023)
IntroductionCryptococcus neoformans is a basidiomycete fungus that can cause meningoencephalitis, especially in immunocompromised patients. Cryptococcus grows in many different media, although little attention has been paid to the role of growth cond
Externí odkaz:
https://doaj.org/article/b9f329651c3f42faad0f3ad02a3787e0
Autor:
Brenda Moreira-Walsh, Abigail Ragsdale, Woei Lam, Rajendra Upadhya, Evan Xu, Jennifer K. Lodge, Maureen J. Donlin
Publikováno v:
mSphere, Vol 7, Iss 4 (2022)
ABSTRACT The fungal pathogen Cryptococcus neoformans causes up to 278 000 infections each year globally, resulting in up to 180,000 deaths annually, mostly impacting immunocompromised people. Therapeutic options for C. neoformans infections are very
Externí odkaz:
https://doaj.org/article/287a6576aeb14462913d260a5d003496
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
Externí odkaz:
https://doaj.org/article/cc11c181a5484e1ea39a44d29f932218
Autor:
Rajendra Upadhya, Woei C. Lam, Camaron R. Hole, Danealle Parchment, Chrono K. Lee, Charles A. Specht, Stuart M. Levitz, Jennifer K. Lodge
Publikováno v:
The Cell Surface, Vol 7, Iss , Pp 100066- (2021)
Chitosan, a deacetylated form of chitin, is required for the virulence of Cryptococcus neoformans. There are three chitin deacetylase genes (CDA) that are essential for chitosan production, and deletion of all three genes results in the absence of ch
Externí odkaz:
https://doaj.org/article/6e8b69ee789c4441b354836b1b93ffaf
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Cryptococcus neoformans infections are significant causes of morbidity and mortality among AIDS patients and the third most common invasive fungal infection in organ transplant recipients. One of the main interfaces between the fungus and th
Externí odkaz:
https://doaj.org/article/b8b69574390d42e7869ca5cc72624bfa
Autor:
Brian T. Maybruck, Woei C. Lam, Charles A. Specht, Ma. Xenia G. Ilagan, Maureen J. Donlin, Jennifer K. Lodge
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Cryptococcus neoformans can cause fatal meningoencephalitis in patients with AIDS or other immunocompromising conditions. Current antifungals are suboptimal to treat this disease; therefore, novel targets and new therapies are needed. Previo
Externí odkaz:
https://doaj.org/article/b3cde10d9e614e4c8f1c4ec327805652
Autor:
Woei C. Lam, Rajendra Upadhya, Charles A. Specht, Abigail E. Ragsdale, Camaron R. Hole, Stuart M. Levitz, Jennifer K. Lodge
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Cryptococcus gattii R265 is a hypervirulent fungal strain responsible for the recent outbreak of cryptococcosis in Vancouver Island of British Columbia in Canada. It differs significantly from Cryptococcus neoformans in its natural environme
Externí odkaz:
https://doaj.org/article/a3f9a04f2eba4ac6b1976aa0d535e3d5
Autor:
Rajendra Upadhya, Lorina G. Baker, Woei C. Lam, Charles A. Specht, Maureen J. Donlin, Jennifer K. Lodge
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Chitin is an essential component of the cell wall of Cryptococcus neoformans conferring structural rigidity and integrity under diverse environmental conditions. Chitin deacetylase genes encode the enyzmes (chitin deacetylases [Cdas]) that d
Externí odkaz:
https://doaj.org/article/d6e613ec492c4b0b8e3f5e22fe269e90