Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jennifer K. Hoffman"'
Autor:
John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
Publikováno v:
ChemMedChem. 8:1295-1313
Polo-like kinase-2 (Plk-2) has been implicated as the dominant kinase involved in the phosphorylation of α-synuclein in Lewy bodies, which are one of the hallmarks of Parkinson's disease neuropathology. Potent, selective, brain-penetrant inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9de472a2de2bc218c1224fe31845aba
https://doi.org/10.1002/cmdc.201300166
https://doi.org/10.1002/cmdc.201300166
Autor:
Cornel Catana, Lisa A. Perrin, Jeff Ohren, Jeremy J. Edmunds, John Quin, Derek James Sheehan, Sangita M. Baxi, Jennifer K. Hoffman, Jeffrey T. Kohrt, Amy M. Delaney, Fred L. Ciske, Michael Kaufman, Noel A. Powell, Patrick I. McConnell
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1046-1050
We report the SAR around a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase. 2-Aminophenethyl analogs demonstrate excellent potency but moderate kinase selectivity, while 2-aminobenzyl analogs that fill the Ala571 subpocket exhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e92f1efe3db497d0cd75fdd02d80d7f
https://doi.org/10.1016/j.bmcl.2012.12.013
https://doi.org/10.1016/j.bmcl.2012.12.013
Autor:
Jennifer K. Hoffman, Masaaki Seki, Scott R. McKercher, Tayebeh Rezaie, Tomomi Kitagawa, Carmen R. Sunico, Gregory P. Roth, Mutsumi Senzaki, Takumi Satoh, Chihiro Kosegawa, Hideharu Taira, Takahito Tabuchi, Stuart A. Lipton, Mika Yanagitai
Publikováno v:
Journal of Neurochemistry. 119:569-578
Activation of the Keap1/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and consequent induction of phase 2 antioxidant enzymes is known to afford neuroprotection. Here, we present a series of novel electrophilic compounds that protect neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::522748803bc04a45975ea1a10837d5bc
https://doi.org/10.1111/j.1471-4159.2011.07449.x
https://doi.org/10.1111/j.1471-4159.2011.07449.x
Autor:
Koji Yamagata, Jack J. Kinsora, Paul Galatsis, Kristin Knapp Lin, Abdul E. Mutlib, Zhuang Nian, John A. Wendt, Corinne E. Augelli-Szafran, Christopher S. Knauer, Susan M. Lotarski, Korana Stakich, Wing Lam, Jared B.J. Milbank, Kristen K. Gillespie, John W. Thomas, Jennifer K. Hoffman, Mickelson John, Annette T. Sakkab-Tan, Roy D. Schwarz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4415-4418
Rational replacement of the alkyne linker of mGluR5 antagonist MPEP gave 7-arylquinolines. SAR optimization gave an orally active compound with high affinity for the MPEP binding site.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3646d2769bbdf8508858926949751b08
https://doi.org/10.1016/j.bmcl.2007.06.030
https://doi.org/10.1016/j.bmcl.2007.06.030
Autor:
Paul Beroza, Michael P. Bova, Jennifer K. Hoffman, Jennifer Sealy, Heather Zhang, Marcelle Bergeron, Linnea Diep, Danny Tam, Ruth Motter, Zhao Ren, R. Jeffrey Neitz, Danielle L. Aubele, Kent Fitzgerald, Michael Ye, Wayman Chan, Pearl Tanaka, Deepal Pandya, Donald J. Fauss, Andrei W. Konradi, John P. Anderson, Roy K. Hom, Dean R. Artis, Hing L. Sham, Robert A. Galemmo, George Tonn, Jeanne Baker, Lany Ruslim, Yong L. Zhu, Anh P. Truong, Michael S. Dappen, Simeon Bowers
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(9)
Polo-like kinase-2 (Plk-2) is a potential therapeutic target for Parkinson’s disease and this Letter describes the SAR of a series of dihydropteridinone based Plk-2 inhibitors. By optimizing both the N-8 substituent and the biaryl region of the inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53291bed2d270abeea1ef72781386bf
https://pubmed.ncbi.nlm.nih.gov/23522834
https://pubmed.ncbi.nlm.nih.gov/23522834
Autor:
Jeffrey T. Kohrt, Noel A. Powell, Lisa A. Perrin, Zhong Min, Jeff Ohren, Fred L. Ciske, Jennifer K. Hoffman, Yun-Wen Peng, Cornel Catana, Jeremy J. Edmunds, Sangita M. Baxi
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(4)
Optimization of the ADME properties of a series of 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase resulted in the identification of highly selective compounds with properties suitable for use as in vitro and in vivo tools to probe the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58da2991526f2d62bcfa9358aa636552
https://pubmed.ncbi.nlm.nih.gov/23312943
https://pubmed.ncbi.nlm.nih.gov/23312943
Autor:
Takumi, Satoh, Tayebeh, Rezaie, Masaaki, Seki, Carmen R, Sunico, Takahito, Tabuchi, Tomomi, Kitagawa, Mika, Yanagitai, Mutsumi, Senzaki, Chihiro, Kosegawa, Hideharu, Taira, Scott R, McKercher, Jennifer K, Hoffman, Gregory P, Roth, Stuart A, Lipton
Publikováno v:
Journal of neurochemistry. 119(3)
Activation of the Keap1/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and consequent induction of phase 2 antioxidant enzymes is known to afford neuroprotection. Here, we present a series of novel electrophilic compounds that protect neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81c8bb6520cb85ac4604e7818a7417d8
https://pubmed.ncbi.nlm.nih.gov/21883218
https://pubmed.ncbi.nlm.nih.gov/21883218
Autor:
Diana Pechter, Jennifer K. Hoffman, Esther A. Guzmán, John K. Reed, Tara P. Pitts, Daniela Divlianska, Amy E. Wright, Patricia Linley, Gregory P Roth, Shirley A. Pomponi, Susan H. Sennett, Peter J. McCarthy
A new adenine substituted bromotyrosine derived metabolite designated as aphrocallistin (1) has been isolated from the deep-water Hexactinellida sponge Aphrocallistes beatrix beatrix Gray, 1858 (Order Hexactinosida, Family Aphrocallistidae). Its stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f7855a13644993f1c711320c2f1858
https://europepmc.org/articles/PMC3031448/
https://europepmc.org/articles/PMC3031448/
Autor:
Paul C. Unangst, Filzen Gary Frederick, Bharat K. Trivedi, Gina Lu, Jennifer K. Hoffman, Geyer Andrew George, Larry D. Bratton, Jim Pulaski, Xiangyang Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(13)
A series of 1,4-benzyloxybenzylsulfanylaryl carboxylic acids were prepared and their activities for PPAR receptor subtypes (alpha, delta, and gamma) with potential indications for the treatment of dyslipidemia were investigated. Analog 13a displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::309c5085884d7c1a65df25ca0caaa2cd
https://pubmed.ncbi.nlm.nih.gov/17498950
https://pubmed.ncbi.nlm.nih.gov/17498950