Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Jennifer K Thompson"'
Autor:
Xavier Sisquella, Thomas Nebl, Jennifer K Thompson, Lachlan Whitehead, Brian M Malpede, Nichole D Salinas, Kelly Rogers, Niraj H Tolia, Andrea Fleig, Joseph O’Neill, Wai-Hong Tham, F David Horgen, Alan F Cowman
Publikováno v:
eLife, Vol 6 (2017)
The most lethal form of malaria in humans is caused by Plasmodium falciparum. These parasites invade erythrocytes, a complex process involving multiple ligand-receptor interactions. The parasite makes initial contact with the erythrocyte followed by
Externí odkaz:
https://doaj.org/article/15d068bfaa714745a0742afd4682f57d
Autor:
Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium falciparum causes malaria in humans with over 450,000 deaths annually. The asexual blood stage involves invasion of erythrocytes by merozoites, in which they grow and divide to release daughter merozoites, which in turn invade new erythroc
Externí odkaz:
https://doaj.org/article/1713c79e917b4c25b466cdbbb54f5a40
Autor:
Julie Healer, Jennifer K Thompson, David T Riglar, Danny W Wilson, Yu-H C Chiu, Kazutoyo Miura, Lin Chen, Anthony N Hodder, Carole A Long, Diana S Hansen, Jake Baum, Alan F Cowman
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72504 (2013)
A highly effective vaccine against Plasmodium falciparum malaria should induce potent, strain transcending immunity that broadly protects against the diverse population of parasites circulating globally. We aimed to identify vaccine candidates that f
Externí odkaz:
https://doaj.org/article/83942e4027cb4b7eb95d97939a7fb086
Autor:
Julie Healer, Jennifer K. Thompson, Karen L. Mackwell, Cecille D. Browne, Benjamin A. Seager, Anna Ngo, Kym N. Lowes, Sarah E. Silk, David Pulido, Lloyd D. W. King, Jayne M. Christen, Amy R. Noe, Vinayaka Kotraiah, Paul J. Masendycz, Rajkannan Rajagopalan, Leanne Lucas, Marianne M. Stanford, Lorraine Soisson, Carter Diggs, Robin Miller, Susan Youll, Kaye Wycherley, Simon J. Draper, Alan F. Cowman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundRH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds to Ripr and CyRPA at the apical end of the invasive merozoite form, and
Externí odkaz:
https://doaj.org/article/84dce22671ea4ea78f35e3a24b9607b4
Autor:
Niall D. Geoghegan, Cindy Evelyn, Lachlan W. Whitehead, Michal Pasternak, Phoebe McDonald, Tony Triglia, Danushka S. Marapana, Daryan Kempe, Jennifer K. Thompson, Michael J. Mlodzianoski, Julie Healer, Maté Biro, Alan F. Cowman, Kelly L. Rogers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Here, Geoghegan, Evelyn et al. provide a lattice light-sheet microscopy based 4D imaging pipeline to quantitatively investigate Plasmodium spp. invasion and show that the nascent parasitophorous vacuole is predominantly formed from host’s erythrocy
Externí odkaz:
https://doaj.org/article/772dfa5515904e51b6b3f89dfb973a19
Autor:
Gregory M. LaMonte, Frances Rocamora, Danushka S. Marapana, Nina F. Gnädig, Sabine Ottilie, Madeline R. Luth, Tilla S. Worgall, Gregory M. Goldgof, Roxanne Mohunlal, T. R. Santha Kumar, Jennifer K. Thompson, Edgar Vigil, Jennifer Yang, Dylan Hutson, Trevor Johnson, Jianbo Huang, Roy M. Williams, Bing Yu Zou, Andrea L. Cheung, Prianka Kumar, Timothy J. Egan, Marcus C. S. Lee, Dionicio Siegel, Alan F. Cowman, David A. Fidock, Elizabeth A. Winzeler
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Imidazolopiperazines (IZPs) are a class of compounds under clinical development for malaria, but their mechanism of action is unclear. Here, the authors show that IZPs inhibit the parasite’s secretory pathway, affecting protein trafficking and expo
Externí odkaz:
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Autor:
Mary-Louise Wilde, Tony Triglia, Danushka Marapana, Jennifer K. Thompson, Alexei A. Kouzmitchev, Hayley E. Bullen, Paul R. Gilson, Alan F. Cowman, Christopher J. Tonkin
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Understanding the mechanisms behind host cell invasion by Plasmodium falciparum remains a major hurdle to developing antimalarial therapeutics that target the asexual cycle and the symptomatic stage of malaria. Host cell entry is enabled by
Externí odkaz:
https://doaj.org/article/e57a13863f35463ca89cb2fe9e8b1b58
Autor:
Jennifer A. Yang, Bing Yu Zou, Frances Rocamora, Edgar Vigil, Prianka Kumar, Nina F. Gnädig, Alan F. Cowman, David A. Fidock, Roy Williams, Trevor Johnson, Madeline R. Luth, Danushka S. Marapana, Dylan Hutson, Marcus C. S. Lee, Tilla S. Worgall, Jianbo Huang, Gregory M. Goldgof, Gregory LaMonte, T. R. Santha Kumar, Jennifer K. Thompson, Timothy J. Egan, Roxanne Mohunlal, Sabine Ottilie, Dionicio Siegel, Elizabeth A. Winzeler, Andrea L. Cheung
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
A promising new compound class for treating human malaria is the imidazolopiperazines (IZP) class. IZP compounds KAF156 (Ganaplacide) and GNF179 are effective against Plasmodium symptomatic asexual blood-stage infections, and are able to prevent tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b18290350407667761814a3f37b90a3
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
https://doaj.org/article/30325ebc8f1440eb95a7ef787cbdca69
Autor:
Phoebe McDonald, Michael J. Mlodzianoski, Niall D. Geoghegan, Julie Healer, Alan F. Cowman, Cindy Evelyn, Kelly L. Rogers, Danushka S. Marapana, Michal Pasternak, Daryan Kempe, Tony Triglia, Maté Biro, Lachlan Whitehead, Jennifer K. Thompson
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the membrane barrier and obtain entry into cells. The malaria parasite Plasmodium spp. induces biophysical and molecular changes to the erythrocyte membrane th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f215389385add53afed7a217810b2dd
http://europepmc.org/articles/PMC8206130
http://europepmc.org/articles/PMC8206130
Autor:
Peter E. Czabotar, Kate E. Jarman, Alan F. Cowman, Brad E. Sleebs, Justin A Boddey, Jennifer K. Thompson, Richard Bestel de Lezongard, Helene Jousset Sabroux, William Nguyen, Anthony N. Hodder, Matthew T. O'Neill
Publikováno v:
European Journal of Medicinal Chemistry. 154:182-198
Plasmepsin V is an aspartyl protease that plays a critical role in the export of proteins bearing the Plasmodium export element (PEXEL) motif (RxLxQ/E/D) to the infected host erythrocyte, and thus the survival of the malaria parasite. Previously, dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3a5a6426ec917d3db5732d8c22ae66e
https://doi.org/10.1016/j.ejmech.2018.05.022
https://doi.org/10.1016/j.ejmech.2018.05.022