Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jennifer K Nyborg"'
Autor:
Rajeshree Pujari, Richard Hunte, Remy Thomas, Louise van der Weyden, Dan Rauch, Lee Ratner, Jennifer K Nyborg, Juan Carlos Ramos, Yoshimi Takai, Noula Shembade
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004721 (2015)
Persistent activation of NF-κB by the Human T-cell leukemia virus type 1 (HTLV-1) oncoprotein, Tax, is vital for the development and pathogenesis of adult T-cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Externí odkaz:
https://doaj.org/article/59795e6ce34646e6add2be32726c3600
Autor:
Sheena D'Arcy, Karolin Luger, Catherine A. Radebaugh, Liangquan Huang, Xu Chen, Jennifer K. Nyborg, Holli A. Giebler, Daniel D Krzizike, Laurie A. Stargell
Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 on chromatin structure and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba34e4fa4092438b52aac67da0803ce0
https://europepmc.org/articles/PMC4836277/
https://europepmc.org/articles/PMC4836277/
Publikováno v:
Journal of Biological Chemistry. 285:31954-31964
Condensation of chromatin into higher order structures is mediated by intra- and interfiber nucleosome-nucleosome interactions. Our goals in this study were to determine the impact specific activator-dependent histone acetylation had on chromatin con
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1799:266-274
The human T-cell leukemia virus, type-1 (HTLV-1)-encoded Tax protein is required for high-level transcription of the virus. Tax function is strictly dependent upon the phosphorylated form of the cellular transcription factor CREB (pCREB), and togethe
Publikováno v:
Oncogene
Adult T-cell leukemia/lymphoma is a fatal malignancy etiologically linked to infection with the human T-cell leukemia virus (HTLV-1). The virally encoded oncoprotein Tax activates the transcription of HTLV-1 and cellular genes by cooperating with cel
Publikováno v:
Journal of Virology. 82:11939-11947
The etiology of human T-cell leukemia virus type 1 (HTLV-1)-induced adult T-cell leukemia is linked to the expression of the viral oncoprotein Tax. Although the mechanism of retroviral transformation is unknown, Tax interferes with fundamental cellul
Publikováno v:
Molecular Cell. 31:660-670
Cyclic AMP-induced phosphorylation of the transcription factor CREB elicits expression of genes mediating diverse biological functions. In lymphoid organs, the neurotransmitter norepinephrine stimulates beta(2)-adrenergic receptors on B lymphocytes t
Publikováno v:
Molecular and Cellular Biology. 28:1383-1392
The human T-cell leukemia virus-encoded oncoprotein Tax is a potent activator of viral transcription. Tax function is strictly dependent upon the cellular transcription factor CREB, and together they bind cAMP response elements within the viral promo
Autor:
Julita A. Ramírez, Jennifer K. Nyborg
Publikováno v:
Journal of Molecular Biology. 372:958-969
The viral oncoprotein Tax mediates transcriptional activation of human T-cell leukemia virus type 1 (HTLV-1). Both Tax and the cellular transcription factor CREB bind to viral cyclic AMP response elements (vCREs) located in the viral promoter. Tax an
Publikováno v:
Journal of Biological Chemistry. 282:19872-19883
CREB-mediated activation of target gene transcription is stimulated by protein kinase A (PKA) phosphorylation at serine 133. This is followed by recruitment of the coactivators CREB-binding protein (CBP) or p300. Conversely, the decline in expression