Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jennifer K Callaway"'
Autor:
Claudia A McCarthy, Antony Vinh, Alyson A Miller, Anders Hallberg, Mathias Alterman, Jennifer K Callaway, Robert E Widdop
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95762 (2014)
BackgroundIn this study, the neuroprotective effect of a novel nonpeptide AT2R agonist, C21, was examined in a conscious model of stroke to verify a class effect of AT2R agonists as neuroprotective agents.Methods and resultsSpontaneously hypertensive
Externí odkaz:
https://doaj.org/article/e3e2ac36c92a4fceb1b89559b68dc59f
Autor:
Benjamin J Wheaton, Jennifer K Callaway, C Joakim Ek, Katarzyna M Dziegielewska, Norman R Saunders
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26826 (2011)
Spinal cord trauma in the adult nervous system usually results in permanent loss of function below the injury level. The immature spinal cord has greater capacity for repair and can develop considerable functionality by adulthood. This study used the
Externí odkaz:
https://doaj.org/article/7b128cc2eadb4f51b81ced21e5233c62
Autor:
C Joakim Ek, Mark D Habgood, Jennifer K Callaway, Ross Dennis, Katarzyna M Dziegielewska, Pia A Johansson, Ann Potter, Benjamin Wheaton, Norman R Saunders
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12021 (2010)
Cellular mechanisms of secondary damage progression following spinal cord injury remain unclear. We have studied the extent of tissue damage from 15 min to 10 weeks after injury using morphological and biochemical estimates of lesion volume and survi
Externí odkaz:
https://doaj.org/article/420f2954cfa54a43895b67cfaad051f6
Publikováno v:
Behavioural Brain Research. 303:44-52
Evidence from experimental animal studies convincingly argues for a role of pro-inflammatory cytokines due to surgical trauma in causing postoperative cognitive dysfunction. However, other studies have shown exposure to 2–4 h of isoflurane anesthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b089559dc02691dc69af3c80a4b549
https://doi.org/10.1016/j.bbr.2016.01.032
https://doi.org/10.1016/j.bbr.2016.01.032
Publikováno v:
Journal of Alzheimer's Disease. 44:995-1005
Post-operative cognitive dysfunction (POCD) predominantly affects the elderly who suffer memory and concentration deficits after anesthesia and surgery. Animal studies have demonstrated anesthetic alone may contribute to POCD but results are variable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a9a6c64afb56eaa06c84f3f55e48a7
https://doi.org/10.3233/jad-132444
https://doi.org/10.3233/jad-132444
Publikováno v:
Anesthesiology. 117:1091-1101
Background Sevoflurane has been found to increase apoptosis and pathologic markers associated with Alzheimer disease, provoking concern over their potential contribution to postoperative cognitive dysfunction. Methods The effects of anesthesia with 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5c2e5264904bd614a28481f456730f
https://doi.org/10.1097/aln.0b013e31826cb228
https://doi.org/10.1097/aln.0b013e31826cb228
Publikováno v:
European Journal of Anaesthesiology. 29:239-245
BackgroundPostoperative cognitive dysfunction has been reported in young, middle-aged and elderly patients with greater incidence with increasing age. Neurocognitive deficits are associated with anaesthetic exposure in aged rodents but in younger adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc97c14e5e6f85895eb5dc3e987f793
https://doi.org/10.1097/eja.0b013e32835103c1
https://doi.org/10.1097/eja.0b013e32835103c1
Autor:
Peter J Crack, Moses Zhang, Catherine E. Downes, Pedro L Guio-Aguilar, F. Tan, Jennifer K. Callaway, L. O’Donovan
Publikováno v:
Neuropharmacology. 59:416-424
Although sigma 1 (σ(1)) receptors and mitogen-activated protein kinases (MAPKs) are known modulators of neuroprotection, a role for MAPK signaling pathways in σ receptor-mediated neuroprotection has not been investigated in detail.The present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daed7d8bbd3d94e061eadfe3f3179525
https://doi.org/10.1016/j.neuropharm.2010.05.014
https://doi.org/10.1016/j.neuropharm.2010.05.014
Publikováno v:
Pediatric Research. 63:620-624
Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl2) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain. We examined long-term functional and protective actions of preconditioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fffd6237885ffde68818fae14e013022
https://doi.org/10.1203/pdr.0b013e31816d9117
https://doi.org/10.1203/pdr.0b013e31816d9117
Autor:
Joseph A. Nicolazzo, Jessica Anne Steuten, Tien Thuy Nguyen, Jennifer K. Callaway, Susan A. Charman, Bevyn Jarrott, Gregg D Smith, Kasiram Katneni
Publikováno v:
Journal of Pharmacy and Pharmacology. 60:171-178
The plasma pharmacokinetics and brain uptake of the novel neuroprotective agent AM-36 (1-(2-(4-chlorophenyl)-2-hydroxy)ethyl-4-(3,5-bis-(1, 1dimethylethyl)-4-hydroxyphenyl) methylpiperazine) were assessed over 72 h following i.v. administration to ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcfea5a4d84816b284b31a73c21471f
https://doi.org/10.1211/jpp.60.2.0005
https://doi.org/10.1211/jpp.60.2.0005