Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Jennifer K, Sabo"'
Autor:
Elizabeth C. Stahl, Jennifer K. Sabo, Min Hyung Kang, Ryan Allen, Elizabeth Applegate, Shin Eui Kim, Yoonjin Kwon, Anmol Seth, Nicholas Lemus, Viviana Salinas-Rios, Katarzyna Soczek, Marena Trinidad, Linda T. Vo, Chris Jeans, Anna Wozniak, Timothy Morris, Athen Kimberlin, Thomas Foti, David F. Savage, Jennifer A. Doudna
Transient delivery of CRISPR-Cas9 ribonucleoproteins (RNPs) into the central nervous system (CNS) for therapeutic genome editing could avoid limitations of viral vector-based delivery including cargo capacity, immunogenicity, and cost. Here we tested
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5f4275a42165337bdc6ac4459130f9b
https://doi.org/10.1101/2023.04.13.536294
https://doi.org/10.1101/2023.04.13.536294
Autor:
Jennifer K. Sabo, Holly S. Cate
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1031-1049 (2013)
In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are prom
Externí odkaz:
https://doaj.org/article/c61d742cd62c47759726cd7e7aa5a26e
Autor:
Jacob O. Agola, Keoni E. Baty, Kimberly S. Butler, Tamara Howard, Oscar A. Negrete, Cindy R. Sandoval Espinoza, Edwin A. Saada, Jennifer A. Doudna, Angelea Maestas-Olguin, Annette E. LaBauve, Jennifer K Sabo, C. Jeffrey Brinker, Achraf Noureddine, Joseph S. Schoeniger, Rita E. Serda
Publikováno v:
Acta Biomaterialia. 114:358-368
CRISPR gene editing technology is strategically foreseen to control diseases by correcting underlying aberrant genetic sequences. In order to overcome drawbacks associated with viral vectors, the establishment of an effective non-viral CRISPR deliver
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63415 (2013)
Repair in multiple sclerosis involves remyelination, a process in which axons are provided with a new myelin sheath by new oligodendrocytes. Bone morphogenic proteins (BMPs) are a family of growth factors that have been shown to influence the respons
Externí odkaz:
https://doaj.org/article/2936c7d969e14e6982c424278ec2df19
Autor:
Lucas Schirmer, David H. Rowitch, Vivi M. Heine, Jennifer K. Sabo, John C. Silbereis, Steven W. Levison
Publikováno v:
Annals of Neurology. 81:560-571
Objective Neonatal white matter injury (NWMI) is a lesion found in preterm infants that can lead to cerebral palsy. Although antagonists of bone morphogenetic protein (BMP) signaling, such as Noggin, promote oligodendrocyte precursor cell (OPC) produ
Autor:
Cindy R. Sandoval Espinoza, Keoni E. Baty, Edwin A. Saada, Joseph S. Schoeniger, C. Jeffrey Brinker, Achraf Noureddine, Kimberly S. Butler, Tamara Howard, Jacob O. Agola, Annette E. LaBauve, Jennifer K Sabo, Angelea Maestas-Olguin, Rita E. Serda, Jennifer A. Doudna, Oscar A. Negrete
Publikováno v:
Acta Biomaterialia. 121:764
Autor:
Jennifer K. Sabo, Peter Göttle, André Heinen, Nevena Tzekova, Hans-Peter Hartung, Patrick Küry, Klintsy J. Torres, Holly S. Cate, David Kremer, Gene Venables, Carlos Parras
Publikováno v:
The Journal of Neuroscience. 35:906-919
Multiple sclerosis is an autoimmune disease of the CNS resulting in degeneration of myelin sheaths and loss of oligodendrocytes, which means that protection and electrical insulation of axons and rapid signal propagation are impaired, leading to axon
Autor:
Stephen N. Floor, Anirvan Ghosh, Claire Coulon-Bainier, Ashwin A Banfal, Brett T. Staahl, Jennifer K Sabo, Gabriela Acevedo Munares, Madhurima Benekareddy, Cole Urnes, Jennifer A. Doudna
Publikováno v:
Nature biotechnology, vol 35, iss 5
We demonstrate editing of post-mitotic neurons in the adult mouse brain following injection of Cas9 ribonucleoprotein (RNP) complexes in the hippocampus, striatum and cortex. Engineered variants of Cas9 with multiple SV40 nuclear localization sequenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73798444fe303353512c41f0ca325c45
https://escholarship.org/uc/item/4ws3879m
https://escholarship.org/uc/item/4ws3879m
Autor:
Holly S. Cate, Jennifer K. Sabo
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1031-1049 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
In demyelinating disorders such as Multiple Sclerosis (MS), targets of injury are myelin and oligodendrocytes, leading to severe neurological dysfunction. Regenerative therapies aimed at promoting oligodendrocyte maturation and remyelination are prom
Autor:
Jennifer K, Sabo, Vivi, Heine, John C, Silbereis, Lucas, Schirmer, Steven W, Levison, David H, Rowitch
Publikováno v:
Annals of neurology. 81(4)
Neonatal white matter injury (NWMI) is a lesion found in preterm infants that can lead to cerebral palsy. Although antagonists of bone morphogenetic protein (BMP) signaling, such as Noggin, promote oligodendrocyte precursor cell (OPC) production afte