Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jennifer J. Rahn"'
Autor:
Arthur Lau, Jennifer J. Rahn, Mona Chappellaz, Hyunjae Chung, Hallgrimur Benediktsson, Dominique Bihan, Anne von Mässenhausen, Andreas Linkermann, Craig N. Jenne, Stephen M. Robbins, Donna L. Senger, Ian A. Lewis, Justin Chun, Daniel A. Muruve
Publikováno v:
Science Advances. 8
The mechanisms that drive leukocyte recruitment to the kidney are incompletely understood. Dipeptidase-1 (DPEP1) is a major neutrophil adhesion receptor highly expressed on proximal tubular cells and peritubular capillaries of the kidney. Renal ische
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1b21d72603433148913b43ca1112fc
https://doi.org/10.1126/sciadv.abm0142
https://doi.org/10.1126/sciadv.abm0142
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59218 (2013)
Opa1 catalyzes fusion of inner mitochondrial membranes and formation of the cristae. OPA1 mutations in humans lead to autosomal dominant optic atrophy. OPA1 knockout mice lose viability around embryonic day 9 from unknown reasons, indicating that OPA
Externí odkaz:
https://doaj.org/article/d5fc080521d74891a7610b99f9922bec
Autor:
Jennifer J. Rahn
Publikováno v:
CourseSource. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1db8bc97a8fa057a014d5e577f18b972
https://doi.org/10.24918/cs.2020.43
https://doi.org/10.24918/cs.2020.43
Autor:
Shivatheja Soma, Jennifer J. Rahn, Haarin Chun, Alison C. Vicary, Aren Boulet, Jonathan D. Gitlin, Andrew J. Latimer, Byung-Eun Kim, Scot C. Leary, Vishal M. Gohil, Shrishiv A. Timbalia, Sherine S.L. Chan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Inherited pathogenic mutations in genes required for copper delivery to cytochrome c oxidase (CcO) perturb mitochondrial energy metabolism and result in fatal mitochondrial disease. A prior attempt to treat human patients with these muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c766929edee9e6b281ec386c9b2475
http://europepmc.org/articles/PMC6094114
http://europepmc.org/articles/PMC6094114
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25652 (2011)
Many debilitating conditions are linked to bioenergetic defects. Developing screens to probe the genetic and/or chemical basis for such links has proved intractable. Furthermore, there is a need for a physiologically relevant assay of bioenergetics i
Externí odkaz:
https://doaj.org/article/9ed4560aeb7d42c594becd9289075565
Autor:
LiMei Wang, Jennifer J Rahn, XueQing Lun, Beichen Sun, John J P Kelly, Samuel Weiss, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Publikováno v:
PLoS Biology, Vol 6, Iss 11, p e289 (2008)
The multifunctional signaling protein p75 neurotrophin receptor (p75(NTR)) is a central regulator and major contributor to the highly invasive nature of malignant gliomas. Here, we show that neurotrophin-dependent regulated intramembrane proteolysis
Externí odkaz:
https://doaj.org/article/98d550cb27f54275989b23eb6180621d
Autor:
Angela L M Johnston, Xueqing Lun, Jennifer J Rahn, Abdelhamid Liacini, Limei Wang, Mark G Hamilton, Ian F Parney, Barbara L Hempstead, Stephen M Robbins, Peter A Forsyth, Donna L Senger
Publikováno v:
PLoS Biology, Vol 5, Iss 8, p e212 (2007)
The invasive nature of cancers in general, and malignant gliomas in particular, is a major clinical problem rendering tumors incurable by conventional therapies. Using a novel invasive glioma mouse model established by serial in vivo selection, we id
Externí odkaz:
https://doaj.org/article/33ea284446f5469189343a2d90b1d815
Autor:
Donna L. Senger, Parvez Vora, Paul Kubes, Chitra Venugopal, Bo Young Ahn, Sheila K. Singh, Stephen M. Robbins, Mana Alshehri, Selina K. Jorch, Liane Babes, Xueqing Lun, Xiaoguang Hao, J. Gregory Cairncross, Jennifer J. Rahn
Publikováno v:
Biomaterials. 252:120105
Despite extensive molecular characterization, human glioblastoma remains a fatal disease with survival rates measured in months. Little improvement is seen with standard surgery, radiotherapy and chemotherapy. Clinical progress is hampered by the ina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d345cd3b4072e8495d8b33ad9bcb65
https://doi.org/10.1016/j.biomaterials.2020.120105
https://doi.org/10.1016/j.biomaterials.2020.120105
Publikováno v:
Nucleic Acids Research
DNA polymerase gamma (POLG) is essential for replication and repair of mitochondrial DNA (mtDNA). Mutations in POLG cause mtDNA instability and a diverse range of poorly understood human diseases. Here, we created a unique Polg animal model, by modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e1ad06da09c61ca541842706864a25
http://europepmc.org/articles/PMC4666367
http://europepmc.org/articles/PMC4666367
Autor:
Jennifer L. Harmon, Joseph L. Alge, Joshua E. Kneff, Craig Beeson, Jennifer J. Rahn, Rick G. Schnellmann, John M. Arthur, L. Jay Stallons, Sherine S.L. Chan, Ryan M. Whitaker
Publikováno v:
Kidney international
Recent studies show the importance of mitochondrial dysfunction in the initiation and progression of acute kidney injury (AKI). However, no biomarkers exist linking renal injury to mitochondrial function and integrity. To this end, we evaluated urina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833a816f6f606ae01c0915f625e97b4c
http://europepmc.org/articles/PMC4675682
http://europepmc.org/articles/PMC4675682