Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jennifer J. Marden"'
Autor:
David B. Sauer, Jennifer J. Marden, Joseph C. Sudar, Jinmei Song, Christopher Mulligan, Da-Neng Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
DASS carboxylate transporters linked to metabolic diseases couple the Na+ gradient to nutrient uptake. Here, the authors unravel the structural basis by which Na+ binding coordinates substrate interactions, revealing a distinct coupling mechanism.
Externí odkaz:
https://doaj.org/article/91c93804bc594b8eab63527045308f23
Autor:
David B Sauer, Noah Trebesch, Jennifer J Marden, Nicolette Cocco, Jinmei Song, Akiko Koide, Shohei Koide, Emad Tajkhorshid, Da-Neng Wang
Publikováno v:
eLife, Vol 9 (2020)
Citrate, α-ketoglutarate and succinate are TCA cycle intermediates that also play essential roles in metabolic signaling and cellular regulation. These di- and tricarboxylates are imported into the cell by the divalent anion sodium symporter (DASS)
Externí odkaz:
https://doaj.org/article/539d34b7a7c747f68b846074d27714c4
Autor:
David B Sauer, Noah Trebesch, Jennifer J Marden, Nicolette Cocco, Jinmei Song, Akiko Koide, Shohei Koide, Emad Tajkhorshid, Da-Neng Wang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcc06980b1d529eb54e7f0eccdb86dd7
https://doi.org/10.7554/elife.61350.sa2
https://doi.org/10.7554/elife.61350.sa2
Publikováno v:
Biochemical Journal. 411:531-541
c-Src has been shown to activate NF-kappaB (nuclear factor kappaB) following H/R (hypoxia/reoxygenation) by acting as a redox-dependent IkappaBalpha (inhibitory kappaB) tyrosine kinase. In the present study, we have investigated the redox-dependent m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9117bb217b37ad483f6eeb97bf3ce8ea
https://doi.org/10.1042/bj20071534
https://doi.org/10.1042/bj20071534
Autor:
Kathryn Nelson, Maged M. Harraz, Jennifer J. Marden, Henry L. Paulson, John F. Engelhardt, Meihui Luo, Aislinn J. Williams
Publikováno v:
Journal of Clinical Investigation. 117:2913-2919
Amyotrophic lateral sclerosis (ALS), one of the most common adult-onset neurodegenerative diseases, has no known cure. Enhanced redox stress and inflammation have been associated with the pathoprogression of ALS through a poorly defined mechanism. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a398ae028afe35dd6a5b7f5c68c1212
https://doi.org/10.1172/jci31265
https://doi.org/10.1172/jci31265
Autor:
Heather MacLennan, Margaret S. Thompson, Yasuyuki Kishimoto, David C. Beier, Kyu-Ho Lee, Steven L. Johnson, Mattias Hammerschmidt, Leonard I. Zon, John H. Postlethwaite, Stephen J. Pratt, Jennifer J. Marden, Stefan Schulte-Merker
Publikováno v:
Developmental Genetics. 23:97-103
The BMP family of polypeptide growth factors has been shown to play diverse roles in establishing embryonic patterning and tissue fates. We report the cloning of the zebrafish homologue of BMP-2, examine its expression during embryogenesis, and find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a94ff561fc5ef3a470f36079e1c1177
https://doi.org/10.1002/(sici)1520-6408(1998)23:2<97::aid-dvg1>3.0.co
https://doi.org/10.1002/(sici)1520-6408(1998)23:2<97::aid-dvg1>3.0.co
Publikováno v:
Chemical Research in Toxicology. 9:994-1000
The carcinogenicity of epoxide compounds has been attributed to covalent binding to DNA. Whereas monoepoxides form only monoadducts, diepoxides can form both monoadducts and interstrand cross-links. The latter are believed to be the more significant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240f9ec9e743e5323bb1283d313b3d71
https://doi.org/10.1021/tx960059c
https://doi.org/10.1021/tx960059c
Autor:
Jennifer J. Marden, Christian Schöneich, Kathryn Nelson, Aislinn J. Williams, Henry L. Paulson, Maged M. Harraz, Victor S. Sharov, Meihui Luo, John F. Engelhardt, Yulong Zhang, Weihong Zhou
Publikováno v:
Journal of Clinical Investigation.
This is the publisher's version, also available electronically from http://www.jci.org/articles/view/34060
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1250e88825229393c9491ff4905836bb
https://doi.org/10.1172/jci34060
https://doi.org/10.1172/jci34060
Autor:
Jonathan B Weitzman, Meihui Luo, Jennifer J. Marden, Paul B. McCray, Weihong Zhou, Hongpeng Jia, Fredrick D. Oakley, Moshe Yaniv, John F. Engelhardt, Yulong Zhang
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (11), pp.6687-6695. ⟨10.1074/jbc.M705606200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (11), pp.6687-6695. ⟨10.1074/jbc.M705606200⟩
The AP-1 transcription factor modulates a wide range of cellular processes, including cellular proliferation, programmed cell death, and survival. JunD is a major component of the AP-1 complex following liver ischemia/reperfusion (I/R) injury; howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a31bbd35cc50820120acc45ff33768
https://pubmed.ncbi.nlm.nih.gov/18182393
https://pubmed.ncbi.nlm.nih.gov/18182393
Publikováno v:
Molecular Therapy. 13
Reactive oxygen species (ROS) generated by phagocytes are well recognized as critical components in the innate immune system. Furthermore, cellular redox stress generated following infection with a number of pathogenic viruses such as HIV has also be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0259cc44c8ef7d2e5b6456d09e882c51