Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Jennifer J. Linderman"'
Autor:
Patrick C. Kinnunen, Brock A. Humphries, Gary D. Luker, Kathryn E. Luker, Jennifer J. Linderman
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Single cancer cells within a tumor exhibit variable levels of resistance to drugs, ultimately leading to treatment failures. While tumor heterogeneity is recognized as a major obstacle to cancer therapy, standard dose-response measurements f
Externí odkaz:
https://doaj.org/article/e9d2e1fcf43e45e48dc5c893a3cd6bb6
Autor:
Patrick C. Kinnunen, Kenneth K. Y. Ho, Siddhartha Srivastava, Chengyang Huang, Wanggang Shen, Krishna Garikipati, Gary D. Luker, Nikola Banovic, Xun Huan, Jennifer J. Linderman, Kathryn E. Luker
Publikováno v:
Frontiers in Systems Biology, Vol 4 (2024)
Cellular heterogeneity is a ubiquitous aspect of biology and a major obstacle to successful cancer treatment. Several techniques have emerged to quantify heterogeneity in live cells along axes including cellular migration, morphology, growth, and sig
Externí odkaz:
https://doaj.org/article/be160e1e9e7845c4a5123e42183ab88b
Publikováno v:
Frontiers in Systems Biology, Vol 3 (2024)
Computational models of disease progression have been constructed for a myriad of pathologies. Typically, the conceptual implementation for pathology-related in silico intervention studies has been ad hoc and similar in design to experimental studies
Externí odkaz:
https://doaj.org/article/86874475a14645c9a49b4ee563927aac
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Some persistent infections provide a level of immunity that protects against reinfection with the same pathogen, a process referred to as concomitant immunity. To explore the phenomenon of concomitant immunity during Mycobacterium tuberculos
Externí odkaz:
https://doaj.org/article/2142c077147c49f5b7fe08c4bb5950db
Autor:
Emily K. Makowski, Patrick C. Kinnunen, Jie Huang, Lina Wu, Matthew D. Smith, Tiexin Wang, Alec A. Desai, Craig N. Streu, Yulei Zhang, Jennifer M. Zupancic, John S. Schardt, Jennifer J. Linderman, Peter M. Tessier
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Optimising antibody properties such as affinity can be detrimental to other key properties. Here the authors use machine learning to simplify the identification of antibodies with co-optimal levels of affinity and specificity for a clinical-stage ant
Externí odkaz:
https://doaj.org/article/0014043dced04499aebddc31d0764ef0
Publikováno v:
Frontiers in Astronomy and Space Sciences, Vol 10 (2023)
The space physics research community is not diverse. This is especially true at the senior experience levels, but is even true for our student populations, which are also not matching the demographics of the general public. Striving towards a demogra
Externí odkaz:
https://doaj.org/article/76fa1d6f29a74e7fb0dc02cfe103d752
Autor:
Joseph M. Cicchese, Awanti Sambarey, Denise Kirschner, Jennifer J. Linderman, Sriram Chandrasekaran
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Tuberculosis (TB) is the deadliest infectious disease worldwide. The design of new treatments for TB is hindered by the large number of candidate drugs, drug combinations, dosing choices, and complex pharmaco-kinetics/dynamics (PK/PD). Here
Externí odkaz:
https://doaj.org/article/58251f8464314b818121f7cf9632b6a2
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/bf3567b2577c4e5a9d254f761658596f
Autor:
Caitlin Hult, Joshua T. Mattila, Hannah P. Gideon, Jennifer J. Linderman, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Neutrophil infiltration into tuberculous granulomas is often associated with higher bacteria loads and severe disease but the basis for this relationship is not well understood. To better elucidate the connection between neutrophils and pathology in
Externí odkaz:
https://doaj.org/article/ffd382aa6ff94234b3091ff7cd878378
Autor:
Jess A. Millar, J. Russell Butler, Stephanie Evans, Nicole L. Grant, Joshua T. Mattila, Jennifer J. Linderman, JoAnne L. Flynn, Denise E. Kirschner
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Tuberculosis (TB) is a worldwide health problem; successful interventions such as vaccines and treatment require a 2better understanding of the immune response to infection with Mycobacterium tuberculosis (Mtb). In many infectious diseases, pathogen-
Externí odkaz:
https://doaj.org/article/18bc1f958e4442d3b25681c8a9dfda80