Human-to-monkey transfer learning identifies the frontal white matter as a key determinant for predicting monkey brain age

Autor: Sheng He, Yi Guan, Chia Hsin Cheng, Tara L. Moore, Jennifer I. Luebke, Ronald J. Killiany, Douglas L. Rosene, Bang-Bon Koo, Yangming Ou

Publikováno v: Frontiers in Aging Neuroscience, Vol 15 (2023)

The application of artificial intelligence (AI) to summarize a whole-brain magnetic resonance image (MRI) into an effective “brain age” metric can provide a holistic, individualized, and objective view of how the brain interacts with various fact

Externí odkaz: https://doaj.org/article/18a53ee6f34d4d16a366adb3a1a82a1a

Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice

Autor: Anne B. Rocher, Michael S. Kinson, Jennifer I. Luebke

Publikováno v: Neurobiology of Disease, Vol 32, Iss 2, Pp 309-318 (2008)

Amyloid-beta (Aβ) plays a key role in the etiology of Alzheimer's disease, and pyramidal cell dendrites exposed to Aβ exhibit dramatic structural alterations, including reduced dendritic spine densities. To determine whether such structural alterat

Externí odkaz: https://doaj.org/article/e1746f28bf7f461ca627579483e7ccf4

Comparative Features of Calretinin, Calbindin and Parvalbumin Expressing Interneurons in Mouse and Monkey Primary Visual and Frontal Cortices

Autor: Maria Medalla, Bingxin Mo, Rakin Nasar, Yuxin Zhou, Junwoo Park, Jennifer I Luebke

Much is known about differences in pyramidal cells across cortical areas and species, but studies of interneurons have focused on comparisons within single cortical areas and/or species. Here we quantified the distribution and somato-dendritic morpho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a1a6228fda7487f6347f9a7a588956f
https://doi.org/10.1101/2023.02.27.530269

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Autor: Srinidhi Venkatesan Kalavai, Zhi Ruan, Jennifer I. Luebke, Yuzhi Wang, Rakez Kayed, Asuka Yoshii-Kitahara, Dhruba Pathak, Satoshi Muraoka, Santhi Gorantla, Seiko Ikezu, Tsuneya Ikezu, Samuel Hersh, Kayo Takamatsu-Yukawa, Nemil Bhatt, Maria Ericsson, Howard E. Gendelman, Jianqiao Hu

Publikováno v: Brain

Ruan et al. show that brain-derived extracellular vesicles from human donors with Alzheimer’s disease propagate tau more efficiently when injected into the mouse hippocampus than oligomeric or fibrillary tau from the same donors. The extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb7e7735bd5cf449163bee641d74954
https://doi.org/10.1093/brain/awaa376

Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice

Autor: Merina Varghese, Patrick R. Hof, Emma Catherine Hays, Srinidhi Venkatesan Kalavai, Jennifer I. Luebke, Dhruba Pathak, Seiko Ikezu, W. Evan Johnson, Maria Medalla, Tsuneya Ikezu, Jean-Christophe Delpech

Publikováno v: Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (611), ⟨10.1126/scitranslmed.abe8455⟩
Science translational medicine

Abnormally phosphorylated tau, an early neuropathologic marker of Alzheimer’s disease (AD), first occurs in the brain’s entorhinal cortex layer II (ECII) and then spreads to the CA1 field of the hippocampus. Animal models of tau propagation aimin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ef2c728f807d54cba1024b4994e114
https://doi.org/10.1126/scitranslmed.abe8455