Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer I. Lai"'
Autor:
Isabel Valsecchi, Jennifer I. Lai, Emmanuel Stephen-Victor, Ariane Pillé, Audrey Beaussart, Victor Lo, Chi L.L. Pham, Vishukumar Aimanianda, Ann H. Kwan, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Melanie Lehoux, Donald C. Sheppard, Yves F. Dufrene, Jagadeesh Bayry, J. Iñaki Guijarro, Margaret Sunde, Jean-Paul Latgé
Publikováno v:
The Cell Surface, Vol 5, Iss , Pp - (2019)
The rodlet structure present on the Aspergillus fumigatus conidial surface hides conidia from immune recognition. In spite of the essential biological role of the rodlets, the molecular basis for their self-assembly and disaggregation is not known. A
Externí odkaz:
https://doaj.org/article/9aea5c49822e42faa2daaf32f00647a5
Autor:
Susan K. Eszterhas, Karl E. Griswold, Margaret E. Ackerman, Chris Bailey-Kellogg, Susan Zolla-Pazner, Michael S. Seaman, Jennifer I. Lai, Chengzi Guo, Seth A. Brooks
Publikováno v:
Vaccine
Highlights • K155M stabilizes V1V2 β-strand conformation relevant to broad antibody recognition. • β-strand stabilized V1V2 immunogens elicit antibody responses with greater cross-reactivity. • Fine-tuning immunogen conformation modulates imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59efffc0ab66ffb6aa76818d9af51861
https://doi.org/10.1016/j.vaccine.2020.03.010
https://doi.org/10.1016/j.vaccine.2020.03.010
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17042 (2011)
Alginate lyase enzymes represent prospective biotherapeutic agents for treating bacterial infections, particularly in the cystic fibrosis airway. To effectively deimmunize one therapeutic candidate while maintaining high level catalytic proficiency,
Externí odkaz:
https://doaj.org/article/70e3c1c343d9462c9be2bdfc4b106346
Autor:
Mangala Rao, Ying N. Chan, Galit Alter, Nana Yaw Osei-Owusu, Genoveffa Franchini, Alison E. Mahan, Erica Normandin, Jennifer I. Lai, Margaret E. Ackerman, Eric P. Brown, Monica Vaccari
Publikováno v:
Journal of Immunological Methods. 425:27-36
Glycosylation of the Fc domain is an important driver of antibody effector function. While assessment of antibody glycoform compositions observed across total plasma IgG has identified differences associated with a variety of clinical conditions, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3595db8e186bed8d493bd1036fa1ea9
Publikováno v:
Protein Engineering, Design and Selection
Structure-based approaches to antigen design utilize insights from antibody (Ab):antigen interactions and a refined understanding of protective Ab responses to engineer novel antigens presenting epitopes with conformations relevant to eliciting or di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1999fdb0d89f6e3951b5121924cb41a0
https://pubmed.ncbi.nlm.nih.gov/29897567
https://pubmed.ncbi.nlm.nih.gov/29897567
Publikováno v:
Protein Engineering Design and Selection. 24:845-853
Non-immune human antibody fragment libraries have generated antigen-binding proteins useful as prospective research, imaging, diagnostic and therapeutic agents. However, because the generation of such libraries relies on cloning antibody sequences fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fad425f0ca695e72410087d96b90b744
https://doi.org/10.1093/protein/gzr046
https://doi.org/10.1093/protein/gzr046
Publikováno v:
Hawai'i journal of medicinepublic health : a journal of Asia Pacific MedicinePublic Health. 73(7)
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominate cancer syndrome that leads to an increased risk of developing invasive diffuse type (signet ring cell) gastric carcinoma. Approximately 30% of HDGC cases are caused by a germline mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e433fcf7b0f5d8db62af31084e9959fe
https://pubmed.ncbi.nlm.nih.gov/25089230
https://pubmed.ncbi.nlm.nih.gov/25089230
Autor:
Jennifer I. Lai, Todd J. Suscovich, Margaret E. Ackerman, Anna Licht, Chris Bailey-Kellogg, Galit Alter, Anne-Sophie Dugast, Ickwon Choi
Publikováno v:
Journal of virology. 88(5)
Understanding the coordination between humoral and cellular immune responses may be the key to developing protective vaccines, and because genetic studies of long-term HIV-1 nonprogressors have associated specific HLA-B alleles with spontaneous contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71abaff51fd725cfe8ef2d76abad6084
https://pubmed.ncbi.nlm.nih.gov/24352471
https://pubmed.ncbi.nlm.nih.gov/24352471