Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Jennifer I Luebke"'
Publikováno v:
eLife, Vol 12 (2024)
Normal aging leads to myelin alterations in the rhesus monkey dorsolateral prefrontal cortex (dlPFC), which are positively correlated with degree of cognitive impairment. It is hypothesized that remyelination with shorter and thinner myelin sheaths p
Externí odkaz:
https://doaj.org/article/a85f2f9571c24d57a3b2e9ffb96be2fb
Autor:
Joseph W Goodliffe, Hanbing Song, Anastasia Rubakovic, Wayne Chang, Maria Medalla, Christina M Weaver, Jennifer I Luebke
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200626 (2018)
Huntington's Disease (HD) is an autosomal dominant, progressive neurodegenerative disorder caused by deleterious expansion of CAG repeats in the Huntingtin gene and production of neurotoxic mutant Huntingtin protein (mHTT). The key pathological featu
Externí odkaz:
https://doaj.org/article/c178b9412fe648b4b86435fb870688df
Autor:
Sheng He, Yi Guan, Chia Hsin Cheng, Tara L. Moore, Jennifer I. Luebke, Ronald J. Killiany, Douglas L. Rosene, Bang-Bon Koo, Yangming Ou
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
The application of artificial intelligence (AI) to summarize a whole-brain magnetic resonance image (MRI) into an effective “brain age” metric can provide a holistic, individualized, and objective view of how the brain interacts with various fact
Externí odkaz:
https://doaj.org/article/18a53ee6f34d4d16a366adb3a1a82a1a
Publikováno v:
Neurobiol Aging
Layer 3 (L3) pyramidal neurons in aged rhesus monkey lateral prefrontal cortex (LPFC) exhibit significantly elevated excitability in vitro and reduced spine density compared to neurons in young subjects. The time-course of these alterations, and whet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d47b46e250d2abed1486eac2be7a3ff
https://doi.org/10.1016/j.neurobiolaging.2021.09.012
https://doi.org/10.1016/j.neurobiolaging.2021.09.012
Much is known about differences in pyramidal cells across cortical areas and species, but studies of interneurons have focused on comparisons within single cortical areas and/or species. Here we quantified the distribution and somato-dendritic morpho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1a6228fda7487f6347f9a7a588956f
https://doi.org/10.1101/2023.02.27.530269
https://doi.org/10.1101/2023.02.27.530269
Autor:
Tara L. Moore, Maria Medalla, Sara Ibañez, Klaus Wimmer, Chromewell A. Mojica, Ronald J. Killiany, Mark B. Moss, Jennifer I. Luebke, Douglas L. Rosene
Publikováno v:
bioRxiv
Age-related declines in cognitive abilities occur as early as middle-age in humans and rhesus monkeys. Specifically, performance by aged individuals on tasks of executive function (EF) and working memory (WM) is characterized by greater frequency of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aebe35aef2ae9436323995715ba45753
https://europepmc.org/articles/PMC9934587/
https://europepmc.org/articles/PMC9934587/
Autor:
Srinidhi Venkatesan Kalavai, Zhi Ruan, Jennifer I. Luebke, Yuzhi Wang, Rakez Kayed, Asuka Yoshii-Kitahara, Dhruba Pathak, Satoshi Muraoka, Santhi Gorantla, Seiko Ikezu, Tsuneya Ikezu, Samuel Hersh, Kayo Takamatsu-Yukawa, Nemil Bhatt, Maria Ericsson, Howard E. Gendelman, Jianqiao Hu
Publikováno v:
Brain
Ruan et al. show that brain-derived extracellular vesicles from human donors with Alzheimer’s disease propagate tau more efficiently when injected into the mouse hippocampus than oligomeric or fibrillary tau from the same donors. The extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb7e7735bd5cf449163bee641d74954
https://doi.org/10.1093/brain/awaa376
https://doi.org/10.1093/brain/awaa376
Autor:
Tara L. Moore, Teresa Guillamon-Vivancos, Silas E. Busch, Maria Medalla, Mathias Nittmann, Anastasia Kapitonava, S. Ibáñez, Douglas L. Rosene, Jennifer I. Luebke, Wayne Chang
Publikováno v:
Cereb Cortex
The laminar cellular and circuit mechanisms by which the anterior cingulate cortex (ACC) exerts flexible control of motor and affective information for goal-directed behavior have not been elucidated. Using multimodal tract-tracing, in vitro patch-cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811803f5a0becde68836c13d67d772e7
http://hdl.handle.net/10261/286260
http://hdl.handle.net/10261/286260
Significant structural but not physiological changes in cortical neurons of 12-month-old Tg2576 mice
Publikováno v:
Neurobiology of Disease, Vol 32, Iss 2, Pp 309-318 (2008)
Amyloid-beta (Aβ) plays a key role in the etiology of Alzheimer's disease, and pyramidal cell dendrites exposed to Aβ exhibit dramatic structural alterations, including reduced dendritic spine densities. To determine whether such structural alterat
Externí odkaz:
https://doaj.org/article/e1746f28bf7f461ca627579483e7ccf4
Autor:
Merina Varghese, Patrick R. Hof, Emma Catherine Hays, Srinidhi Venkatesan Kalavai, Jennifer I. Luebke, Dhruba Pathak, Seiko Ikezu, W. Evan Johnson, Maria Medalla, Tsuneya Ikezu, Jean-Christophe Delpech
Publikováno v:
Science Translational Medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (611), ⟨10.1126/scitranslmed.abe8455⟩
Science translational medicine
Science Translational Medicine, American Association for the Advancement of Science, 2021, 13 (611), ⟨10.1126/scitranslmed.abe8455⟩
Science translational medicine
Abnormally phosphorylated tau, an early neuropathologic marker of Alzheimer’s disease (AD), first occurs in the brain’s entorhinal cortex layer II (ECII) and then spreads to the CA1 field of the hippocampus. Animal models of tau propagation aimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ef2c728f807d54cba1024b4994e114
https://doi.org/10.1126/scitranslmed.abe8455
https://doi.org/10.1126/scitranslmed.abe8455