Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Jennifer Haynes"'
Publikováno v:
Cells, Vol 13, Iss 19, p 1623 (2024)
In the small intestine, sodium (Na) absorption occurs primarily via two apical transporters, Na-hydrogen exchanger 3 (NHE3) and Na-glucose cotransporter 1 (SGLT1). The two primary Na-absorptive pathways were previously shown to compensatorily regulat
Externí odkaz:
https://doaj.org/article/d8d15bd8297b403ea4ac89eda2262f7c
Autor:
Evelyne Lima-Fernandes, Alex Murison, Tiago da Silva Medina, Yadong Wang, Anqi Ma, Cherry Leung, Genna M. Luciani, Jennifer Haynes, Aaron Pollett, Constanze Zeller, Shili Duan, Antonija Kreso, Dalia Barsyte-Lovejoy, Bradly G. Wouters, Jian Jin, Daniel D. De Carvalho, Mathieu Lupien, Cheryl H. Arrowsmith, Catherine A. O’Brien
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The presence of bivalent epigenetic active and repressive histone marks control lineage-specific differentiation in embryonic stem cells. Here, the authors reveal that bivalent marks repress the differentiation gene IHH in colorectal cancer-initiatin
Externí odkaz:
https://doaj.org/article/03a72eb189654119bb1c127366a2d06f
Publikováno v:
Cells, Vol 10, Iss 4, p 752 (2021)
The primary means of intestinal absorption of nutrients by villus cells is via Na-dependent nutrient co-transporters located in the brush border membrane (BBM). These secondary active co-transport processes require a favorable transcellular Na gradie
Externí odkaz:
https://doaj.org/article/b9a0a7f735184a21b404f6f51cbcb746
Autor:
Olmo Sonzogni, Jennifer Haynes, Laurie A Seifried, Yahia M Kamel, Kai Huang, Michael D BeGora, Faith Au Yeung, Celine Robert-Tissot, Yujing J Heng, Xin Yuan, Gerbug M Wulf, Ken J Kron, Elvin Wagenblast, Mathieu Lupien, Thomas Kislinger, Gregory J Hannon, Senthil K Muthuswamy
Publikováno v:
PLoS Biology, Vol 16, Iss 6, p e2004049 (2018)
The contribution of basal and luminal cells to cancer progression and metastasis is poorly understood. We report generation of reporter systems driven by either keratin-14 (K14) or keratin-8 (K8) promoter that not only express a fluorescent protein b
Externí odkaz:
https://doaj.org/article/5f14a8b0f9b94d6189d917aeaebfeb35
Publikováno v:
Translational Research. 248:22-35
Recently developed human intestinal epithelial 3D organoid cultures are a useful cell culture model to study intestinal transport physiology. From these, 2D monolayer cultures can be generated in which apical transporters are exposed to the medium, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8575748f6aaa2d842468327a74706af0
https://doi.org/10.1016/j.trsl.2022.04.008
https://doi.org/10.1016/j.trsl.2022.04.008
Publikováno v:
Clinical Psychology Forum. 1:82-88
Primary Mental Health Treatment Requirements (PMHTR) are one of three under the umbrella ‘Community Sentence Treatment Requirements’. PMHTRs have been designed to reduce offenders’ recidivism by offering psychological therapy to individuals wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dddb1df697a634c7126c5a821dc38918
https://doi.org/10.53841/bpscpf.2022.1.356.82
https://doi.org/10.53841/bpscpf.2022.1.356.82
Autor:
Catherine A. O'Brien, Myles Smith, David A. Jaffray, Ur Metser, Bradly G. Wouters, Benjamin Haibe-Kains, Douglass C. Vines, Eva Szentgyorgyi, Robin Wolman, Antonija Kreso, Evelyne Lima-Fernandes, Deena M.A. Gendoo, Cherry Leung, Yadong Wang, Andrew Haller, Trevor D. McKee, Jennifer Haynes
Supplementary Table S1. Summary of colorectal cancer patient samples used in this study. The tissue site from which samples originated or were collected, disease stage, and main driver mutations are listed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0ea1804f011934b7b631ac1ecf295a9
https://doi.org/10.1158/1078-0432.22465224.v1
https://doi.org/10.1158/1078-0432.22465224.v1
Autor:
Catherine A. O'Brien, Myles Smith, David A. Jaffray, Ur Metser, Bradly G. Wouters, Benjamin Haibe-Kains, Douglass C. Vines, Eva Szentgyorgyi, Robin Wolman, Antonija Kreso, Evelyne Lima-Fernandes, Deena M.A. Gendoo, Cherry Leung, Yadong Wang, Andrew Haller, Trevor D. McKee, Jennifer Haynes
Supplementary Materials and Methods (unmarked)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6121fd688dc5856600080ce0d0fde086
https://doi.org/10.1158/1078-0432.22465227.v1
https://doi.org/10.1158/1078-0432.22465227.v1
Autor:
Catherine A. O'Brien, Myles Smith, David A. Jaffray, Ur Metser, Bradly G. Wouters, Benjamin Haibe-Kains, Douglass C. Vines, Eva Szentgyorgyi, Robin Wolman, Antonija Kreso, Evelyne Lima-Fernandes, Deena M.A. Gendoo, Cherry Leung, Yadong Wang, Andrew Haller, Trevor D. McKee, Jennifer Haynes
Purpose: Cancer-initiating cells (C-IC) have been described in multiple cancer types, including colorectal cancer. C-ICs are defined by their capacity to self-renew, thereby driving tumor growth. C-ICs were initially thought to be static entities; ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1452cdb0e92c4135903aac1fe2ece67b
https://doi.org/10.1158/1078-0432.c.6525963.v1
https://doi.org/10.1158/1078-0432.c.6525963.v1
Autor:
Catherine A. O'Brien, Myles Smith, David A. Jaffray, Ur Metser, Bradly G. Wouters, Benjamin Haibe-Kains, Douglass C. Vines, Eva Szentgyorgyi, Robin Wolman, Antonija Kreso, Evelyne Lima-Fernandes, Deena M.A. Gendoo, Cherry Leung, Yadong Wang, Andrew Haller, Trevor D. McKee, Jennifer Haynes
Supplementary Figure S1. Hypoxia increases stem gene expression and stabilizes HIF proteins. Supplementary Figure S2. Chemotherapy enriches for colorectal C-IC markers and increases expression of Wnt and HIF targets. Supplementary Figure S3. Growth o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899d3b90e208e9498e6b4e001f8cfdb4
https://doi.org/10.1158/1078-0432.22465230.v1
https://doi.org/10.1158/1078-0432.22465230.v1