Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jennifer Hanisak"'
Autor:
Essam Metwally, Victor Mak, Aileen Soriano, Matthias Zebisch, H. Leonardo Silvestre, Paul A. McEwan, Grigori Ermakov, Maribel Beaumont, Paul Tawa, John J. Barker, Rose Yen, Akash Patel, Yeon-Hee Lim, David Healy, Jennifer Hanisak, Alan C. Cheng, Tom Greshock, Thierry O. Fischmann
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract cGMP-dependent protein kinase I-α (PKG1α) is a target for pulmonary arterial hypertension due to its role in the regulation of smooth muscle function. While most work has focused on regulation of cGMP turnover, we recently described severa
Externí odkaz:
https://doaj.org/article/35e2c7e8e424458aafb60de67b006cea
Autor:
J. Cameron Twitty, Yun Hong, Bria Garcia, Stephanie Tsang, Jennie Liao, Danielle M. Schultz, Jennifer Hanisak, Susan L. Zultanski, Amelie Dion, Dipannita Kalyani, Mary P. Watson
Publikováno v:
Journal of the American Chemical Society. 145:5684-5695
Autor:
Victor W. Mak, Akash M. Patel, Rose Yen, Jennifer Hanisak, Yeon-Hee Lim, Jianming Bao, Rong Zheng, W. Michael Seganish, Yang Yu, David R. Healy, Aimie Ogawa, Zhao Ren, Aileen Soriano, Grigori P. Ermakov, Maribel Beaumont, Essam Metwally, Alan C. Cheng, Andreas Verras, Thierry Fischmann, Matthias Zebisch, H. Leonardo Silvestre, Paul A. McEwan, John Barker, Paul Rearden, Thomas J. Greshock
Publikováno v:
Journal of Medicinal Chemistry. 65:10318-10340
Activation of PKG1α is a compelling strategy for the treatment of cardiovascular diseases. As the main effector of cyclic guanosine monophosphate (cGMP), activation of PKG1α induces smooth muscle relaxation in blood vessels, lowers pulmonary blood
Autor:
Paul Tawa, Lei Zhang, Essam Metwally, Yan Hou, Mark A. McCoy, W. Michael Seganish, Rumin Zhang, Emily Frank, Payal Sheth, Jennifer Hanisak, Christopher Sondey, David Bauman, Aileen Soriano
Publikováno v:
The Journal of biological chemistry. 298(9)
cGMP-dependent protein kinase (PKG) represents a compelling drug target for treatment of cardiovascular diseases. PKG1 is the major effector of beneficial cGMP signaling which is involved in smooth muscle relaxation and vascular tone, inhibition of p
Autor:
Andreas Verras, Lei Zhang, Aileen Soriano, Gregory O'Donnell, Emily Frank, Andrea D. Basso, David J. Bell, Paul Tawa, W. Michael Seganish, Jennifer Hanisak, Yang Yu, Gregory C. Adam, David R. Bauman
Publikováno v:
ACS Med Chem Lett
[Image: see text] PKG1α is a central node in cGMP signaling. Current therapeutics that look to activate this pathway rely on elevation of cGMP levels and subsequent activation of PKG1α. Direct activation of PKG1α could potentially drive additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b05d721292d7270027b12125728c49
https://europepmc.org/articles/PMC8365999/
https://europepmc.org/articles/PMC8365999/
Autor:
Christopher Sondey, Theirry Fischmann, Kristine Devito, Haiquin Tang, W. Michael Seganish, Rui Zhang, Jennifer Hanisak, Hon-Chung Tsui, Deen Tulshian, Daniel Lundell, Charles G. Garlisi, William T. McElroy, Xiaoda Niu, James Fossetta, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4250-4255
IRAK4 has been identified as potential therapeutic target for inflammatory and autoimmune diseases. Herein we report the identification and initial SAR studies of a new class of pyrazole containing IRAK4 inhibitors designed to expand chemical diversi
Autor:
Zheng Tan, Steve Sorota, Deen Tulshian, R. Jason Herr, William G. Earley, Charles R. Heap, Stephanie Brumfield, Terry Bridal, Jennifer Hanisak, Xiaoping Zhou, Julius Matasi, Ana Bercovici, Ginny D. Ho, Diane Rindgen, Brandy Courneya, Shu-Wei Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4110-4113
A series of pyrrolo-benzo-1,4-diazine analogs have been synthesized and displayed potent Nav1.7 inhibitory activity and moderate selectivity over Nav1.5. The syntheses, structure-activity relationships, and selected pharmacokinetic data of these anal