Chafe et al Supplementary Data from Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

Autor: Shoukat Dedhar, Sohrab P. Shah, Youwen Zhou, Andrew I. Minchinton, Ali Bashashati, Jordan A. Gillespie, Jennifer H.E. Baker, Alastair H. Kyle, Alberto Delaidelli, Dongxia Gao, Samantha Burugu, Geetha Venkateswaran, Oksana Nemirovsky, Saeed Saberi, Paul C. McDonald, Shawn C. Chafe

Supplementary Figures S1-S6 and Tables S1-S4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62703df9bd4941f7372f5184567b32ca
https://doi.org/10.1158/2326-6066.22542499.v1

Supplemental Figures S4 - S5 from Tissue Penetration and Activity of Camptothecins in Solid Tumor Xenografts

Autor: Andrew I. Minchinton, Stefan A. Reinsberg, Maria-Jose Gandolfo, Jennifer H.E. Baker, Alastair H. Kyle

Supplemental FIGS S4 - S5 - Summary of vascular density, vascular patentcy and tissue hypoxia measurements following camptothecin treatment.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f496631da3adc217aad788a8af93a0
https://doi.org/10.1158/1535-7163.22502899.v1

Supplemental Figure S3 from Tissue Penetration and Activity of Camptothecins in Solid Tumor Xenografts

Autor: Andrew I. Minchinton, Stefan A. Reinsberg, Maria-Jose Gandolfo, Jennifer H.E. Baker, Alastair H. Kyle

Supplemental FIG S3 - Whole tissue section images comparing irinotecan extravasation versus MRI based contrast agent localization.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8da6f1adbb543c88cb106c780aca08
https://doi.org/10.1158/1535-7163.22502905

Supplementary Figures 1 - 6, Table 1 from Endothelial-Specific Notch Blockade Inhibits Vascular Function and Tumor Growth through an eNOS-Dependent Mechanism

Autor: Aly Karsan, Andrew I. Minchinton, Jade Tong, Erika Diaz, Jennifer H.E. Baker, Patricia Umlandt, Alastair H. Kyle, Rebecca Shaw, Grigorios Paliouras, Fred Wong, Linda Chang, Megan Fuller, Alexandre Patenaude

PDF file - 3357K, Figure S1. DnMAML-mediated EC-specific Notch blockade inhibits larger vessel function. Figure S2. Flow cytometry analysis of PDGFRβ in LLC-VEGFA tumors of control and double Tg. Figure S3. NO production in the microvasculature of L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e5d56210438afc365a09ce5fdd0228
https://doi.org/10.1158/0008-5472.22401330

Inter-Metastatic Heterogeneity of Tumor Marker Expression and Microenvironment Architecture in a Preclinical Cancer Model

Autor: Jennifer H.E. Baker, Andrew I. Minchinton, Alastair H. Kyle, Marcel B. Bally, Justin Song, Jessica Kalra

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 6336, p 6336 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 12; Pages: 6336
International Journal of Molecular Sciences

Background: Preclinical drug development studies rarely consider the impact of a candidate drug on established metastatic disease. This may explain why agents that are successful in subcutaneous and even orthotopic preclinical models often fail to de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f4e7ef7a28daa179776e40da77514fb
https://www.mdpi.com/1422-0067/22/12/6336