Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Jennifer H. Ward"'
Autor:
Sunil Lagah, I-Li Tan, Priya Radhakrishnan, Robert A Hirst, Jennifer H Ward, Chris O'Callaghan, Stuart J Smith, Malcolm F G Stevens, Richard G Grundy, Ruman Rahman
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86187 (2014)
BACKGROUND: Telomeric 3' overhangs can fold into a four-stranded DNA structure termed G-quadruplex (G4), a formation which inhibits telomerase. As telomerase activation is crucial for telomere maintenance in most cancer cells, several classes of G4 l
Externí odkaz:
https://doaj.org/article/fbebdeea513a4674910c7dba5d13b9ba
Autor:
Stuart J Smith, Martin Wilson, Jennifer H Ward, Cheryl V Rahman, Andrew C Peet, Donald C Macarthur, Felicity R A J Rose, Richard G Grundy, Ruman Rahman
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52335 (2012)
IntroductionPhysiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated usi
Externí odkaz:
https://doaj.org/article/0b5326e51f734aaabbbf930afbebf33f
Autor:
Donald Macarthur, Maria de los Angeles Estevez-Cebrero, Stuart Smith, Hazel A. Rogers, Jennifer H. Ward, Richard Grundy
INTRODUCTION: Micro-Ribonucleic acids (miRNAs) are short non-protein coding RNAs involved in post-transcriptional regulation of genes by targeting the 3’ region of mRNAs. They have been associated with dysregulation of oncogenes and tumour suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::156f50294bea27dc8c23d1ee65320772
https://europepmc.org/articles/PMC6168819/
https://europepmc.org/articles/PMC6168819/
Publikováno v:
Oncotarget
Aims: Recent studies have observed that cells from high-grade glial tumors are capable of assuming an endothelial phenotype and genotype, a process termed ‘vasculogenic mimicry’ (VM). Here we model and manipulate VM in dynamic 3-dimensional (3D)
Publikováno v:
Brain Pathology. 23:19-27
Pediatric embryonal brain tumors can be difficult to classify. Atypical teratoid rhabdoid tumors (ATRT) contain rhabdoid cells, while primitive neuroectodermal tumors (PNETs) are composed of "small round blue cells." Loss of INI1 is a common event in
Autor:
Kevin M. Shakesheff, Toby W.A. Gould, Ruman Rahman, James E. Dixon, Jennifer H. Ward, James Kelly
INTRODUCTION: Local neurosurgically-applied drug-delivery systems offer an opportunity to target glioblastoma (GBM) residual disease, but consideration must be given to the uptake of delivered agents once diffused from a drug-delivery depot. We asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694d36c2026e8e06b44fac8d9d9a792
https://europepmc.org/articles/PMC4657694/
https://europepmc.org/articles/PMC4657694/
Intratumor heterogeneity exists in many cancers, with clear evidence of differential gene expression temporo-spatially in glioblastoma multiforme (GBM). MicroRNA (miRNA) profiling studies have identified risk-stratifying signatures in GBM, but it has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d922a717cdba1349fe7776ffd60dfeb2
https://europepmc.org/articles/PMC4638788/
https://europepmc.org/articles/PMC4638788/
Autor:
John-Paul Kilday, Steven C. Clifford, Martyna Adamowicz-Brice, Jennifer H. Ward, Richard Grundy, Hazel A. Rogers, Beth Coyle, Edward C. Schwalbe, Cerys Mayne
Publikováno v:
Acta Neuropathologica
Epigenetic alterations, including methylation, have been shown to be an important mechanism of gene silencing in cancer. Ependymoma has been well characterized at the DNA copy number and mRNA expression levels. However little is known about DNA methy
INTRODUCTION: Ependymoma is the second commonest central nervous system malignancy in children. 50% of sufferers relapse and 80% of these subsequently die. Few prognostic factors have been identified but improved outcomes are seen in children over 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdeaf54c19eba86c83f081f29b03ae95
https://europepmc.org/articles/PMC4482956/
https://europepmc.org/articles/PMC4482956/