Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jennifer H. Milbank"'
Autor:
Darren A. Cusanovich, Choli Lee, Melissa D. Zhang, Molly Gasperini, Jay Shendure, Jennifer H. Milbank, Aaron McKenna, Gregory M. Findlay
Publikováno v:
American journal of human genetics. 101(2)
The extent to which non-coding mutations contribute to Mendelian disease is a major unknown in human genetics. Relatedly, the vast majority of candidate regulatory elements have yet to be functionally validated. Here, we describe a CRISPR-based syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79108502a9d23ebb29c34af2371671a9
https://pubmed.ncbi.nlm.nih.gov/28712454
https://pubmed.ncbi.nlm.nih.gov/28712454
Autor:
Jennifer H. Milbank, Zhang, Gregory M. Findlay, Molly Gasperini, Choli Lee, Aaron McKenna, Darren A. Cusanovich, Jay Shendure
The extent to which distal non-coding mutations contribute to Mendelian disease remains a major unknown in human genetics. Given that a gene’s in vivo function can be appropriately modeled in vitro, CRISPR/Cas9 genome editing enables the large-scal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27d21a8ee4b27c39774cdc20a54d403
https://doi.org/10.1101/092445
https://doi.org/10.1101/092445
Autor:
Akash Kumar, Ming Yu, Eva Corey, Stephen J. Salipante, Tom Walsh, Christina Smith, Ilsa Coleman, Jonathan F. Tait, Robert L. Vessella, Jay Shendure, Colin C. Pritchard, William M. Grady, Colm Morrissey, Peter S. Nelson, Jennifer H. Milbank, Xiaotun Zhang
Publikováno v:
Nature Communications
A hypermutated subtype of advanced prostate cancer was recently described, but prevalence and mechanisms have not been well-characterized. Here we find that 12% (7 of 60) of advanced prostate cancers are hypermutated, and that all hypermutated cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f224ba997659c818b1da636e5b41b8
http://europepmc.org/articles/PMC4176888
http://europepmc.org/articles/PMC4176888