Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jennifer H Olker"'
Autor:
Richard S. Judson, Doris Smith, Michael DeVito, John F. Wambaugh, Barbara A. Wetmore, Katie Paul Friedman, Grace Patlewicz, Russell S. Thomas, Risa R. Sayre, Jennifer H. Olker, Sigmund Degitz, Stephanie Padilla, Joshua A. Harrill, Timothy Shafer, Kelly E. Carstens
Publikováno v:
Toxics, Vol 12, Iss 4, p 271 (2024)
Per- and polyfluoroalkyl substances (PFAS) are widely used, and their fluorinated state contributes to unique uses and stability but also long half-lives in the environment and humans. PFAS have been shown to be toxic, leading to immunosuppression, c
Externí odkaz:
https://doaj.org/article/65a7eaa4eb3848ff8e5cf8a509a96a88
Autor:
Jennifer H. Olker, Colleen M. Elonen, Anne Pilli, Arne Anderson, Brian Kinziger, Stephen Erickson, Michael Skopinski, Anita Pomplun, Carlie A. LaLone, Christine L. Russom, Dale Hoff
Publikováno v:
Environ Toxicol Chem
The need for assembled existing and new toxicity data has accelerated as the amount of chemicals introduced into commerce continues to grow and regulatory mandates require safety assessments for a greater number of chemicals. To address this evolving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aded8ddd48742c260ae2a47b219de563
https://doi.org/10.1002/etc.5324
https://doi.org/10.1002/etc.5324
Autor:
Jonathan T Haselman, Jennifer H Olker, Patricia A Kosian, Joseph J Korte, Jeffrey S Denny, Joseph E Tietge, Michael W Hornung, Sigmund J Degitz
Publikováno v:
Toxicol Sci
Iodothyronine deiodinases (DIO) are key enzymes that influence tissue-specific thyroid hormone levels during thyroid-mediated amphibian metamorphosis. Within the larger context of evaluating chemicals for thyroid system disrupting potential, chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb6524a19ef791df91df42dd10d0e95
https://doi.org/10.1093/toxsci/kfac014
https://doi.org/10.1093/toxsci/kfac014
Autor:
Gerald T. Ankley, Jason P. Berninger, Erin M. Maloney, Jennifer H. Olker, Christopher M. Schaupp, Daniel L. Villeneuve, Carlie A. LaLone
Publikováno v:
Environmental toxicology and chemistryREFERENCES.
There are insufficient toxicity data to assess the ecological risks of many pharmaceuticals and personal care products (PPCPs). While data limitations are not uncommon for contaminants of environmental concern, PPCPs are somewhat unique in that an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d298f7cdefd11165e9ab572b880b82
https://pubmed.ncbi.nlm.nih.gov/35735070
https://pubmed.ncbi.nlm.nih.gov/35735070
Autor:
Joseph J. Korte, Jeffrey S. Denny, Jennifer H Olker, Joseph A. Swintek, Patricia A. Kosian, Joseph E. Tietge, John W. Nichols, Sigmund J. Degitz, Jonathan T. Haselman, Michael W. Hornung
Publikováno v:
Toxicol Sci
Chemical safety evaluation is in the midst of a transition from traditional whole-animal toxicity testing to molecular pathway-based in vitro assays and in silico modeling. However, to facilitate the shift in reliance on apical effects for risk asses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0f2fa073d9a14784133cb3ac98477b
https://doi.org/10.1093/toxsci/kfaa036
https://doi.org/10.1093/toxsci/kfaa036
Autor:
Sarah M. Kadlec, Brett R. Blackwell, Chad A. Blanksma, Rodney D. Johnson, Jennifer H. Olker, Patrick K. Schoff, David R. Mount
Publikováno v:
Environmental toxicology and chemistryREFERENCES. 41(6)
Testicular oocytes in wild adult bass (Micropterus spp.) are considered a potential indication of exposure to estrogenic compounds in municipal, agricultural, or industrial wastewater. However, our ability to interpret links between testicular oocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62efee06ce385c94e27d56ca0bf2a594
https://pubmed.ncbi.nlm.nih.gov/35199887
https://pubmed.ncbi.nlm.nih.gov/35199887
Autor:
Jennifer H. Olker, Joseph J. Korte, Jonathan T. Haselman, Michael W. Hornung, Sigmund J. Degitz
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 249
The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca00f1d4e60fbb442259ca1906b6de6
https://pubmed.ncbi.nlm.nih.gov/35767922
https://pubmed.ncbi.nlm.nih.gov/35767922
Autor:
Sigmund J. Degitz, Jennifer H Olker, Phillip C. Hartig, Mary C. Cardon, Jonathan T. Haselman, Joseph J. Korte, Jeffrey S. Denny, Michael W. Hornung
Publikováno v:
Toxicol In Vitro
The iodide recycling enzyme, iodotyrosine deiodinase (IYD), is a largely unstudied molecular mechanism through which environmental chemicals can potentially cause thyroid disruption. This highly conserved enzyme plays an essential role in maintaining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95e32d38a329beb29a438f2710808fe4
https://pubmed.ncbi.nlm.nih.gov/33352258
https://pubmed.ncbi.nlm.nih.gov/33352258
Autor:
Joseph J. Korte, Sigmund J. Degitz, Phillip C. Hartig, Jessica P Christensen, Jennifer H Olker, Paige M Kent, Carsten Knutsen, Mary C. Cardon, Michael W. Hornung, Jeffrey S. Denny
Publikováno v:
Toxicological Sciences. 168:430-442
Deiodinase enzymes play an essential role in converting thyroid hormones between active and inactive forms by deiodinating the pro-hormone thyroxine (T4) to the active hormone triiodothyronine (T3) and modifying T4 and T3 to inactive forms. Chemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8efb5fab58a9168c1f0124bb1a0ce01
https://doi.org/10.1093/toxsci/kfy302
https://doi.org/10.1093/toxsci/kfy302
Autor:
David R. Mount, Patrick K. Schoff, Sarah M. Kadlec, Jennifer H. Olker, Rodney D. Johnson, Brian D. Borkholder
Publikováno v:
Environmental Toxicology and Chemistry. 36:3424-3435
Testicular oocytes (TOs) have been found in black bass (Micropterus spp.) from many locations in North America. The presence of TOs is often assumed to imply exposure to estrogenic endocrine disrupting compounds (EDCs); however, a definitive causal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f940f4f1c8947723a43be5342902acee
https://doi.org/10.1002/etc.3928
https://doi.org/10.1002/etc.3928