Výsledky vyhledávání - "Jennifer Grosjean"

Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study

Autor: Antoine Martin, Stéphane de Botton, Geneviève Le Roux, Simone Boehrer, Claude Gardin, Thorsten Braun, Lorenzo Galluzzi, Guido Kroemer, Lionel Ades, Claire Fabre, Pierre Fenaux, Jennifer Grosjean

Publikováno v: Blood. 111:2170-2180

Erlotinib, an inhibitor of the epidermal growth factor receptor (EGFR), induces differentiation, cell-cycle arrest, and apoptosis of EGFR-negative myeloblasts of patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), as well a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6d9965db5d489ef4f33c51854d021c
https://doi.org/10.1182/blood-2007-07-100362

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Vascular endothelial growth factor signalling in endothelial cell survival: A role for NFκB

Autor: Jennifer Grosjean, Marc Feldmann, Kerri Reilly, Serafim Kiriakidis, Ewa M. Paleolog

Publikováno v: Biochemical and Biophysical Research Communications. 340:984-994

Angiogenesis is the development of blood capillaries from pre-existing vessels. Vascular endothelial growth factor (VEGF) is a key regulator of vessel growth and regression, and acts as an endothelial survival factor by protecting endothelial cells f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99824ca1a3a6bfe4c3de618867119b5d
https://doi.org/10.1016/j.bbrc.2005.12.095

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Erratum to: Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

Autor: Stéphane de Botton, Simone Boehrer, Guido Kroemer, Lionel Ades, Claire Fabre, Jennifer Grosjean-Raillard, Maximilien Tailler, Pierre Fenaux, Alain Israël, Thorsten Braun

Publikováno v: Apoptosis. 20:1666-1667

High-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are characterized by the activation of the anti-apoptotic transcription factor NFκB, via the IKK complex. Here, we show that constitutive activation of the receptor tyrosine k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c927a65f95ed81d29190fc4b03e33f1a
https://doi.org/10.1007/s10495-015-1154-9

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Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

Autor: Jennifer Grosjean-Raillard, Lionel Adès, Simone Boehrer, Maximilien Tailler, Claire Fabre, Thorsten Braun, Stéphane De Botton, Alain Israel, Pierre Fenaux, Guido Kroemer

Publikováno v: Apoptosis : an international journal on programmed cell death. 13(9)

High-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are characterized by the activation of the anti-apoptotic transcription factor NFkappaB, via the IKK complex. Here, we show that constitutive activation of the receptor tyrosin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bece12fb7227245968f9a8b118964d6c
https://pubmed.ncbi.nlm.nih.gov/26400497

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A novel effect of DNA methyltransferase and histone deacetylase inhibitors: NFkappaB inhibition in malignant myeloblasts

Autor: Stéphane de Botton, Maximilien Tailler, Simone Boehrer, Lionel Ades, Claire Fabre, Jean-Luc Perfettini, Guido Kroemer, Pierre Fenaux, Jennifer Grosjean

Publikováno v: Cell cycle (Georgetown, Tex.). 7(14)

Malignant myeloblasts arising in high-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are characterized by the constitutive activation of the anti-apoptotic transcription factor NFkappaB. We found that DNA methyltransferase (DNMT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d845b57e2eed2518388679dde90ce399
https://pubmed.ncbi.nlm.nih.gov/18641459

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Differentiating megakaryocytes in myelodysplastic syndromes succumb to mitochondrial derangement without caspase activation

Autor: Jennifer Grosjean, C. Fabre, Pierre Fenaux, Gabrielle Carvalho, Guido Kroemer, Lionel Ades, Najet Debili, Simone Boehrer, Thorsten Braun

Publikováno v: Apoptosis : an international journal on programmed cell death. 12(6)

Myelodysplastic syndromes (MDS) constitute a preneoplastic condition in which potentially malignant cancer stem cells continuously die during differentiation. This MDS-associated cell death often involves caspase-3 activation, yet can also occur with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee356d092d277ada584053ae8b38d21
https://pubmed.ncbi.nlm.nih.gov/17245643

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Cyclooxygenase-2 induction and prostacyclin release by protease-activated receptors in endothelial cells require cooperation between mitogen-activated protein kinase and NF-kappaB pathways

Autor: Farisa Syeda, Caroline P.D. Wheeler-Jones, Rosemary J. Keogh, Ewa M. Paleolog, Jennifer Grosjean, Tom Carter, Rebecca A. Houliston

Publikováno v: The Journal of biological chemistry. 281(17)

The functional significance of protease-activated receptors (PARs) in endothelial cells is largely undefined, and the intracellular consequences of their activation are poorly understood. Here, we show that the serine protease thrombin, a PAR-1-selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4acd72d4a4a55c257d996418443b064d
https://pubmed.ncbi.nlm.nih.gov/16467309

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Flt3 Receptor Inhibition Abolishes Constitutive NFκB Activation in High-Risk Myelodysplastic Syndrome and Acute Myeloid Leukemia

Autor: Pierre Fenaux, Lionel Adès, Simone Bohrer, Jennifer Grosjean, Guido Kroemer

Publikováno v: Blood. 110:2434-2434

High-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are characterized by the constitutive activation of the anti-apoptotic transcription factor NF-kappaB, via the activation of the IKK complex. We show that constitutive activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63bcf66f1f1c5aca44b7f512808a0045
https://doi.org/10.1182/blood.v110.11.2434.2434

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The EGFR-Inhibitor Erlotinib Induces Differentiation, Cell Cycle Arrest and Apoptosis in EGFR-Negative Cells of MDS and AML

Autor: Guido Kroemer, Lionel Ades, Claire Fabre, Pierre Fenaux, Antoine Martin, Thorsten Braun, Simone Boehrer, Jennifer Grosjean, Lorenzo Galluzzi, Claude Gardin, Geneviève Le Roux, Stéphane de Botton

Publikováno v: Blood. 110:399-399

Background: The EGFR-inhibitor erlotinib was designed to antagonize the deregulated EGFR-activity in solid tumors. After showing that the EGFR-inhibitor erlotinib induces apoptosis in EGFR-negative ex vivo cells of patients with MDS and AML while spa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31a7d3b41a24af06242537b8a80aa0ef
https://doi.org/10.1182/blood.v110.11.399.399

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Further Evidence That MDS and AML Cells Exhibit a Differential Capacity To Activate the DNA-Damage Response (DDR) Pathways

Autor: Guido Kroemer, Lorenzo Galluzzi, Ken A. Olaussen, Pierre Fenaux, Thorsten Braun, Simone Boehrer, Stéphane de Botton, Lionel Ades, Claire Fabre, Jennifer Grosjean

Publikováno v: Blood. 110:2438-2438

Background: Findings, that activation of the DDR-pathway in preneoplastic lesions of solid neoplasms slows tumorigenesis, could also underly progression of MDS to AML. We previously showed (ASH 2006, abstr n° 2649), that - in contrast to the de novo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4751a324d2c1e8ea8d11ede360da012b
https://doi.org/10.1182/blood.v110.11.2438.2438

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