Protease activated receptor-2 expression and function in asthmatic bronchial smooth muscle.

Autor: Benoit Allard, Imane Bara, Guillaume Gilbert, Gabrielle Carvalho, Thomas Trian, Annaig Ozier, Jennifer Gillibert-Duplantier, Olga Ousova, Elise Maurat, Matthieu Thumerel, Jean-François Quignard, Pierre-Olivier Girodet, Roger Marthan, Patrick Berger

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e86945 (2014)

Asthmatic bronchial smooth muscle (BSM) is characterized by structural remodeling associated with mast cell infiltration displaying features of chronic degranulation. Mast cell-derived tryptase can activate protease activated receptor type-2 (PAR-2)

Externí odkaz: https://doaj.org/article/32d3d3639d524853848b27283d297663

Signaling Pathways Linked to Serotonin-Induced Superoxide Anion Production: A Physiological Role for Mitochondria in Pulmonary Arteries

Autor: Mathilde Dubois, Marie Billaud, Roger Marthan, Jennifer Gillibert-Duplantier, Nafiisha Genet, Rodrigue Rossignol, Jean-Pierre Savineau, Christelle Guibert, Brant E. Isakson

Publikováno v: Frontiers in Physiology

Serotonin (5-HT) is a potent vasoconstrictor agonist and contributes to several vascular diseases including systemic or pulmonary hypertension and atherosclerosis. Although superoxide anion (O2•) is commonly associated to cellular damages due to O2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c522b646d6eba7e8b48f98f8d9bc737c
https://doi.org/10.3389/fphys.2017.00076

Protease-activated receptor 1 knockout reduces experimentally induced liver fibrosis

Autor: Anne Rullier, Nathalie Dugot-Senant, Jean Rosenbaum, Jennifer Gillibert-Duplantier, Gérard Déléris, Cyril Petibois, Pierre Costet, Gaelle Cubel, Valérie Haurie, Paulette Bioulac-Sage, Danièle Taras

Publikováno v: AJP-Gastrointestinal and Liver Physiology
AJP-Gastrointestinal and Liver Physiology, 2008, 294 (1), pp.G226-35. ⟨10.1152/ajpgi.00444.2007⟩

Thrombin inhibition protects against liver fibrosis. However, it is not known whether the thrombin profibrogenic effect is due to effects on blood coagulation or to signaling via protease-activated receptors (PARs). We took advantage of the lack of b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d43669519b81c8d6853c718c7987ecf
https://doi.org/10.1152/ajpgi.00444.2007

Identification and characterization of two dipeptidyl-peptidase III isoforms in Drosophila melanogaster

Autor: Claire Mazzocco, Kayoko M. Fukasawa, Marc Bonneu, Jennifer Gillibert-Duplantier, Véronique Neaud, Jacques Puiroux, Stéphane Claverol

Publikováno v: FEBS Journal. 273:1056-1064

Dipeptidyl-peptidase III (DPP III) hydrolyses small peptides with a broad substrate specificity. It is thought to be involved in a major degradation pathway of the insect neuropeptide proctolin. We report the purification and characterization of a so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7029688f0f823bb3396a93a22058a1f7
https://doi.org/10.1111/j.1742-4658.2006.05132.x

Liver myofibroblasts activate protein C and respond to activated protein C

Autor: Véronique Neaud, Jennifer Gillibert-Duplantier, Walter Kisiel, Jean Rosenbaum, Anne Rullier

Publikováno v: World Journal of Gastroenterology. 16:210

To study the protein C activation system in human liver myofibroblasts, and the effects of activated protein C (APC) on these cells.Human liver myofibroblasts were obtained by outgrowth. Expression of protease activated receptor 1 (PAR-1), endothelia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488c515f6ea0cafe836b64aedc4f3ca7
https://doi.org/10.3748/wjg.v16.i2.210