Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Jennifer Giandhari"'
Autor:
Stefanie Hossmann, Antoine Jaquet, Matthias Egger, Richard Lessells, Jeremy Ross, Mamatha Sauermann, Tom Loosli, Selma Riedo, Niko Beerenwinkel, Albert Minga, Jennifer Giandhari, Roger D Kouyos
Publikováno v:
BMJ Open, Vol 14, Iss 8 (2024)
Introduction HIV drug resistance poses a challenge to the United Nation’s goal of ending the HIV/AIDS epidemic. The integrase strand transfer inhibitor (InSTI) dolutegravir, which has a higher resistance barrier, was endorsed by the WHO in 2019 for
Externí odkaz:
https://doaj.org/article/cdb698d44ddf40a39cf421b625d97203
Autor:
Khadija Khan, Farina Karim, Yashica Ganga, Mallory Bernstein, Zesuliwe Jule, Kajal Reedoy, Sandile Cele, Gila Lustig, Daniel Amoako, Nicole Wolter, Natasha Samsunder, Aida Sivro, James Emmanuel San, Jennifer Giandhari, Houriiyah Tegally, Sureshnee Pillay, Yeshnee Naidoo, Matilda Mazibuko, Yoliswa Miya, Nokuthula Ngcobo, Nithendra Manickchund, Nombulelo Magula, Quarraisha Abdool Karim, Anne von Gottberg, Salim S. Abdool Karim, Willem Hanekom, Bernadett I. Gosnell, COMMIT-KZN Team, Richard J. Lessells, Tulio de Oliveira, Mahomed-Yunus S. Moosa, Alex Sigal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-7 (2022)
Emerging SARS-CoV-2 Omicron sub-lineages BA.4 and BA.5 raise concerns about potential immune evasion. Here, Khan et al. show that both BA.4 and BA.5 are able to escape immune response induced by prior BA.1 infection, but that this effect is less pron
Externí odkaz:
https://doaj.org/article/e33f1969012c445a9979f3a62e870904
Autor:
Benjamin Chimukangara, Richard J. Lessells, Benn Sartorius, Lilishia Gounder, Sontaga Manyana, Melendhran Pillay, Lavanya Singh, Jennifer Giandhari, Kerusha Govender, Reshmi Samuel, Nokukhanya Msomi, Kogieleum Naidoo, Tulio de Oliveira, Pravi Moodley, Raveen Parboosing
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 29, Iss , Pp 468-475 (2022)
ABSTRACT: Objectives: In low–middle-income countries, increasing levels of HIV drug resistance (HIVDR) on second-line protease inhibitor (PI)-based regimens are a cause for concern given the limited drug options for third-line antiretroviral therap
Externí odkaz:
https://doaj.org/article/06c595bd500c4b65a557b119ab107495
Autor:
Nicholas Bbosa, Deogratius Ssemwanga, Hamidah Namagembe, Ronald Kiiza, Jocelyn Kiconco, John Kayiwa, Tom Lutalo, Julius Lutwama, Alfred Ssekagiri, Isaac Ssewanyana, Susan Nabadda, Henry Kyobe-Bbosa, Jennifer Giandhari, Sureshnee Pillay, Upasana Ramphal, Yajna Ramphal, Yeshnee Naidoo, Derek Tshiabuila, Houriiyah Tegally, Emmanuel J. San, Eduan Wilkinson, Tulio de Oliveira, Pontiano Kaleebu
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 5, Pp 1021-1025 (2022)
Genomic surveillance in Uganda showed rapid replacement of severe acute respiratory syndrome coronavirus 2 over time by variants, dominated by Delta. However, detection of the more transmissible Omicron variant among travelers and increasing communit
Externí odkaz:
https://doaj.org/article/c722de1348544f1c9e7a5461c191f850
Autor:
Vinicius Vieira, Nicholas Lim, Alveera Singh, Ellen Leitman, Reena Dsouza, Emily Adland, Maximilian Muenchhoff, Julia Roider, Miguel Marin Lopez, Julieta Carabelli, Jennifer Giandhari, Andreas Groll, Pieter Jooste, Julia G. Prado, Christina Thobakgale, Krista Dong, Photini Kiepiela, Andrew J. Prendergast, Gareth Tudor-Williams, John Frater, Bruce D. Walker, Thumbi Ndung’u, Veron Ramsuran, Alasdair Leslie, Henrik N. Kløverpris, Philip Goulder
Publikováno v:
JCI Insight, Vol 8, Iss 3 (2023)
HIV nonprogression despite persistent viremia is rare among adults who are naive to antiretroviral therapy (ART) but relatively common among ART-naive children. Previous studies indicate that ART-naive pediatric slow progressors (PSPs) adopt immune e
Externí odkaz:
https://doaj.org/article/c853642a4fad494d92227bb92d5c7838
Autor:
Nomonde R. Mvelase, Lindiwe P. Cele, Ravesh Singh, Yeshnee Naidoo, Jennifer Giandhari, Eduan Wilkinson, Tulio de Oliveira, Khine Swe Swe-Han, Koleka P. Mlisana
Publikováno v:
African Journal of Laboratory Medicine, Vol 12, Iss 1, Pp e1-e8 (2023)
Background: Rifampicin resistance missed by commercial rapid molecular assays but detected by phenotypic assays may lead to discordant susceptibility results and affect patient management. Objective: This study was conducted to evaluate the causes o
Externí odkaz:
https://doaj.org/article/a7eced0fda2645428229ed14e194d9f7
Autor:
Derek Tshiabuila, Jennifer Giandhari, Sureshnee Pillay, Upasana Ramphal, Yajna Ramphal, Arisha Maharaj, Ugochukwu Jacob Anyaneji, Yeshnee Naidoo, Houriiyah Tegally, Emmanuel James San, Eduan Wilkinson, Richard J. Lessells, Tulio de Oliveira
Publikováno v:
BMC Genomics, Vol 23, Iss 1, Pp 1-17 (2022)
Abstract Background Over 4 million SARS-CoV-2 genomes have been sequenced globally in the past 2 years. This has been crucial in elucidating transmission chains within communities, the development of new diagnostic methods, vaccines, and antivirals.
Externí odkaz:
https://doaj.org/article/f769e42448074a1fb9984d5f5abd8919
Autor:
Cathrine Scheepers, Josie Everatt, Daniel G. Amoako, Houriiyah Tegally, Constantinos Kurt Wibmer, Anele Mnguni, Arshad Ismail, Boitshoko Mahlangu, Bronwen E. Lambson, Darren P. Martin, Eduan Wilkinson, James Emmanuel San, Jennifer Giandhari, Nelia Manamela, Noxolo Ntuli, Prudence Kgagudi, Sandile Cele, Simone I. Richardson, Sureshnee Pillay, Thabo Mohale, Upasana Ramphal, Yeshnee Naidoo, Zamantungwa T. Khumalo, Gaurav Kwatra, Glenda Gray, Linda-Gail Bekker, Shabir A. Madhi, Vicky Baillie, Wesley C. Van Voorhis, Florette K. Treurnicht, Marietjie Venter, Koleka Mlisana, Nicole Wolter, Alex Sigal, Carolyn Williamson, Nei-yuan Hsiao, Nokukhanya Msomi, Tongai Maponga, Wolfgang Preiser, Zinhle Makatini, Richard Lessells, Penny L. Moore, Tulio de Oliveira, Anne von Gottberg, Jinal N. Bhiman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
The SARS-CoV-2 PANGO lineage C.1.2 has been under monitoring by global health authorities as it has spread worldwide. Here, Bhiman and colleagues characterise the emergence of the lineage, and its neutralisation sensitivity using data from vaccinees
Externí odkaz:
https://doaj.org/article/e365317a28774fd29c4b6a0f6a77a17a
Autor:
Kathleen Subramoney, Nkhensani Mtileni, Ashlyn Davis, Jennifer Giandhari, Houriiyah Tegally, Eduan Wilkinson, Yeshnee Naidoo, Yajna Ramphal, Sureshnee Pillay, Upasana Ramphal, Andiswa Simane, Bhaveshan Reddy, Bonolo Mashishi, Nonhlanhla Mbenenge, Tulio de Oliveira, Burtram C Fielding, Florette K Treurnicht
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0286373 (2023)
Intra-host diversity studies are used to characterise the mutational heterogeneity of SARS-CoV-2 infections in order to understand the impact of virus-host adaptations. This study investigated the frequency and diversity of the spike (S) protein muta
Externí odkaz:
https://doaj.org/article/adab5be900f847c7a1d4587d9d8cee08
Autor:
Sureshnee Pillay, James Emmanuel San, Derek Tshiabuila, Yeshnee Naidoo, Yusasha Pillay, Akhil Maharaj, Ugochukwu J Anyaneji, Eduan Wilkinson, Houriiyah Tegally, Richard J Lessells, Cheryl Baxter, Tulio de Oliveira, Jennifer Giandhari
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0283219 (2023)
The global pandemic caused by SARS-CoV-2 has increased the demand for scalable sequencing and diagnostic methods, especially for genomic surveillance. Although next-generation sequencing has enabled large-scale genomic surveillance, the ability to se
Externí odkaz:
https://doaj.org/article/a905d510469b4341bedf460971334fbc