Výsledky vyhledávání - "Jennifer Gardell"

A NOVEL BISPECIFIC CD8 TREG MODULATOR TARGETING CYTOLYTIC CD8 REGULATORY T CELLS REDUCES PATHOGENIC CD4 T CELLS AND INFLAMMATION IN TRANSLATIONAL MODELS OF INTESTINAL AUTOIMMUNE AND INFLAMMATORY DISEASE

Autor: Jennifer Gardell, Daniel Boster, Justin Bowser, Courtney Crane, Rachael Fasnacht, Kristin Fitzpatrick, Gleda Hermansky, Susan Julien, Meghan Maurer, Cathy McMahan, Brent Meengs, Dan Patton, Minh Pham, Kristine Swiderek

Publikováno v: Gastroenterology. 164:S15-S16

INTRODUCTION We have characterized a novel CD8 Treg network in autoimmune patient peripheral blood and tissues, in which a subset of cytolytic CD8 Treg eliminate pathogenic CD4 T cells, reducing inflammation and ameliorating disease in response to pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62b4ce6b039c3f2950999f62ea7ba9d
https://doi.org/10.1053/j.gastro.2023.03.038

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Sa1117: A NEWLY DISCOVERED REGULATORY CD8 T CELL NETWORK HAS THE POTENTIAL TO REGULATE AND ELIMINATE PATHOGENIC CD4 T CELLS IN AUTOIMMUNE MEDIATED DIGESTIVE DISEASE

Autor: Courtney Crane, Justin Bowser, Rachael Fasnacht, Jennifer Gardell, Susan Julien, Meghan Maurer, Megan L. Templeton, Jon Therriault, Kristine M. Swiderek

Publikováno v: Gastroenterology. 162:S-312

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12bbb8ec054b4f3498199292c92ef641
https://doi.org/10.1016/s0016-5085(22)60744-3

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A NEWLY DISCOVERED REGULATORY CD8 T CELL NETWORK HAS THE POTENTIAL TO REGULATE AND ELIMINATE PATHOGENIC CD4 T CELLS IN AUTOIMMUNE MEDIATED DISEASE OF THE GUT

Autor: Courtney Crane, Justin Bowser, Rachael Fasnacht, Jennifer Gardell, Meghan Maurer, Susan Julien, Megan Templeton, Jon Henry Therriault, Kristine Swiderek

Publikováno v: Inflammatory Bowel Diseases. 28:S55-S55

INTRODUCTION Several groups have described a subset of CD8 T cells with immunosuppressive characteristics in inflammatory disease settings. The increased prevalence of a defined subset of CD8 T cells and correlation to disease has been reported in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005d89dfdcc073058a304651924821e4
https://doi.org/10.1093/ibd/izac015.086

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Preformed CD40L is stored in an intracellular, secretory compartment in Th1, Th2, Th17, and T follicular helper cells as well as CD4 single positive thymocytes and invariant NKT cells, but not in Treg cells (63.5)

Autor: David Parker, Abigail Buenafe, Timothy Thauland, Jennifer Gardell, Elizabeth Bivins-Smith, David Jacoby, Mark Slifka, Yoshinobu Koguchi

Publikováno v: The Journal of Immunology. 186:63.5-63.5

CD40L is essential for development of adaptive immune responses. It is generally thought that CD40L is made from new mRNA following antigen recognition like other cytokines. However, we and others have shown that some CD4+ effector and memory cells a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24d564be7334fac8f9f1e45dc7eaff86
https://doi.org/10.4049/jimmunol.186.supp.63.5

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Cyclosporine-resistant, Rab27a-independent mobilization of intracellular preformed CD40L mediates antigen-specific T cell help in vitro (63.8)

Autor: Jennifer Gardell, Timothy Thauland, David Parker, Yoshinobu Koguchi

Publikováno v: The Journal of Immunology. 186:63.8-63.8

CD40L is critically important for the initiation and maintenance of adaptive immune responses. CD40L expression in CD4+ T cells is regulated transcriptionally and produced from new mRNA following antigen recognition. However, recent studies with two-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9891d9945b8bcd18f238618c9986a28
https://doi.org/10.4049/jimmunol.186.supp.63.8

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