Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jennifer G. Chickering"'
Autor:
Daniel P. Zimmer, Courtney M. Shea, Jenny V. Tobin, Boris Tchernychev, Peter Germano, Kristie Sykes, Ali R. Banijamali, Sarah Jacobson, Sylvie G. Bernier, Renee Sarno, Andrew Carvalho, Yueh-tyng Chien, Regina Graul, Emmanuel S. Buys, Juli E. Jones, James D. Wakefield, Gavrielle M. Price, Jennifer G. Chickering, G. Todd Milne, Mark G. Currie, Jaime L. Masferrer
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi
Externí odkaz:
https://doaj.org/article/e994be112c3a40db87031271143e9556
Autor:
George Bakris, Albert T. Profy, Jennifer G. Chickering, Jelena P. Seferovic, John P. Hanrahan, Ian H. de Boer, Michael D. Cressman, Mark G. Currie, James Wakefield, G. Todd Milne, Kenneth E. Carlson, Phebe J. Wilson, Yueh-Tyng Chien
Publikováno v:
Clin J Am Soc Nephrol
Background and objectives Impaired nitric oxide signaling through soluble guanylate cyclase has been implicated in the pathophysiology of diabetic kidney disease. Praliciguat, a soluble guanylate cyclase stimulator that amplifies nitric oxide signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a08796e56d4397df9ed0dd1e1a556
https://doi.org/10.2215/cjn.08410520
https://doi.org/10.2215/cjn.08410520
Autor:
Sarah Jacobson, Jenny Tobin, Renee Sarno, Jaime L. Masferrer, Andrew Carvalho, Boris Tchernychev, Yueh-Tyng Chien, G. Todd Milne, Jennifer G. Chickering, Peter Germano, Ali R. Banijamali, Gavrielle M Price, Emmanuel S. Buys, James Wakefield, Regina Graul, Juli E. Jones, Courtney Shea, Sylvie G. Bernier, Daniel P. Zimmer, Kristie Sykes, Mark G. Currie
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology, Vol 11 (2020)
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235faf214a0dad4f1fdd0e1ad72b1cd8
https://pubmed.ncbi.nlm.nih.gov/32322204
https://pubmed.ncbi.nlm.nih.gov/32322204
Autor:
Regina Graul, Jennifer G. Chickering, Daniel P. Zimmer, Yueh-Tyng Chien, George Todd Milne, Jaime L. Masferrer, John R. Hadcock, Emmanuel S. Buys, Albert T. Profy
Publikováno v:
Nitric Oxide. 78:72-80
Nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC), an enzyme that catalyzes the conversion of guanosine-5'-triphosphate (GTP) to cyclic guanosine-3',5'-monophophate (cGMP), transduces many of the physiological effects of the gasotransmitter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b94683b3d8f60510c8bfee0cfce67b6
https://doi.org/10.1016/j.niox.2018.05.009
https://doi.org/10.1016/j.niox.2018.05.009
Autor:
Linda Morrow, Daniel P. Zimmer, Jennifer G. Chickering, Jelena P. Seferovic, Andrew L. Frelinger, Kenneth E. Carlson, Phebe J. Wilson, Mark G. Currie, G. Todd Milne, James Wakefield, Joon Jung, Albert T. Profy, John P. Hanrahan, Michael Hall, Alan D. Michelson
Publikováno v:
Diabetologia
Aims/hypothesis Praliciguat (IW-1973), a soluble guanylate cyclase stimulator, amplifies nitric oxide signalling. This exploratory trial investigated the safety, tolerability, pharmacokinetic profile and pharmacodynamic effects of praliciguat in indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b4281f0807fbb3e5d7d441113ef655
https://pubmed.ncbi.nlm.nih.gov/31858186
https://pubmed.ncbi.nlm.nih.gov/31858186
Autor:
Michael Hall, Albert T. Profy, Jennifer G. Chickering, Marina Mihova, James Wakefield, G. Todd Milne, Mark G. Currie, John P. Hanrahan, Dennis Ruff, Phebe J. Wilson, Daniel P. Zimmer
Publikováno v:
Diabetes. 67
Background: Impaired nitric oxide (NO) signaling through soluble guanylate cyclase (sGC) has been associated with microvascular complications of diabetes. Praliciguat (IW-1973), an sGC stimulator that enhances NO signaling, reduced fasting plasma glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b06acf37ca739e05831e2ed43a90bed
https://doi.org/10.2337/db18-1207-p
https://doi.org/10.2337/db18-1207-p
Autor:
Albert T. Profy, G. Todd Milne, Marina Mihova, Michael Hall, Dennis Ruff, James Wakefield, Phebe J. Wilson, Mark G. Currie, Jennifer G. Chickering, John P. Hanrahan
Publikováno v:
Clinical pharmacology in drug development. 8(5)
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signaling is central to the regulation of several physiological processes, including blood flow and inflammation. Deficient NO signaling is implicated in multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250b35c417ffa1a1a47e3581662896d2
https://pubmed.ncbi.nlm.nih.gov/30422390
https://pubmed.ncbi.nlm.nih.gov/30422390
Autor:
Anthony Lembo, Bernard J. Lavins, S J Shiff, M Currie, Jeffrey M. Johnston, Jennifer G. Chickering, Xinming Hao, X. D. Jia, Caroline B. Kurtz, Lin Chang
Publikováno v:
Alimentary Pharmacology & Therapeutics
Background Few clinical trials in chronic idiopathic constipation (CIC) patients have evaluated abdominal symptom severity and whether CIC patients with abdominal symptoms respond similarly to patients with limited abdominal symptoms. Aims To examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2242a299b8e7c129a977b2e00743280a
http://europepmc.org/articles/PMC4278547
http://europepmc.org/articles/PMC4278547
Autor:
Correia, Susana S.1 (AUTHOR), Liu, Guang1 (AUTHOR), Jacobson, Sarah1 (AUTHOR), Bernier, Sylvie G.1 (AUTHOR), Tobin, Jenny V.1 (AUTHOR), Schwartzkopf, Chad D.1 (AUTHOR), Atwater, Emily1 (AUTHOR), Lonie, Elisabeth2 (AUTHOR), Rivers, Sam1 (AUTHOR), Carvalho, Andrew1 (AUTHOR), Germano, Peter1 (AUTHOR), Tang, Kim2 (AUTHOR), Iyengar, Rajesh R.1 (AUTHOR), Currie, Mark G.1 (AUTHOR), Hadcock, John R.1 (AUTHOR), Winrow, Christopher J.1 (AUTHOR), Jones, Juli E.1 (AUTHOR) jjones@cyclerion.com
Publikováno v:
Journal of Neuroinflammation. 9/18/2021, Vol. 18 Issue 1, p1-13. 13p.
Autor:
Tchernychev, Boris1 (AUTHOR), Li, Huihui2 (AUTHOR), Lee, Sung‐Kyun2 (AUTHOR), Gao, Xin2 (AUTHOR), Ramanarasimhaiah, Raghunath1 (AUTHOR), Liu, Guang1 (AUTHOR), Hall, Katherine C.1 (AUTHOR), Bernier, Sylvie G.1 (AUTHOR), Jones, Juli E.1 (AUTHOR), Feil, Susanne3 (AUTHOR), Feil, Robert3 (AUTHOR), Buys, Emmanuel S.1 (AUTHOR) ebuys@cyclerion.com, Graul, Regina M.1 (AUTHOR), Frenette, Paul S.2 (AUTHOR), Masferrer, Jaime L.1 (AUTHOR)
Publikováno v:
British Journal of Pharmacology. Sep2021, Vol. 178 Issue 17, p3463-3475. 13p. 10 Graphs.