Výsledky vyhledávání - "Jennifer G. Beaumont"

Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL

Autor: Andreas Strasser, Lorraine A. O'Reilly, David C.S. Huang, Jennifer G. Beaumont, Jerry M. Adams, George Hausmann, Rosemary van Driel

Publikováno v: The Journal of Cell Biology

How Bcl-2 and its pro-survival relatives prevent activation of the caspases that mediate apoptosis is unknown, but they appear to act through the caspase activator apoptosis protease–activating factor 1 (Apaf-1). According to the apoptosome model,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca84b65f2061499c0971301587e41b89
https://doi.org/10.1083/jcb.149.3.623

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Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

Autor: Leigh Coultas, Richard E. Cheney, Andreas Villunger, Jennifer G. Beaumont, Hamsa Puthalakath, Andreas Strasser, David C.S. Huang, Lorraine A. O'Reilly

Publikováno v: Science (New York, N.Y.). 293(5536)

Bcl-2 family members bearing only the BH3 domain are essential inducers of apoptosis. We identified a BH3-only protein, Bmf, and show that its BH3 domain is required both for binding to prosurvival Bcl-2 proteins and for triggering apoptosis. In heal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13447af82cd617dfab2f2de0a727e183
https://pubmed.ncbi.nlm.nih.gov/11546862

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Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

Autor: Julie Wilson-Annan, Lorraine A. O'Reilly, George Hausmann, Jerry M. Adams, Simon Crawford, Trevor Lithgow, Lin Chen, Jennifer G. Beaumont, David C.S. Huang, Loes P Parma, Martin Lackmann, Mark G. Hinds, Catherine L. Day

Publikováno v: Monash University
The Journal of Cell Biology

Prosurvival Bcl-2–like proteins, like Bcl-w, are thought to function on organelles such as the mitochondrion and to be targeted to them by their hydrophobic COOH-terminal domain. We unexpectedly found, however, that the membrane association of Bcl-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b06b9c7f7a7e3fb339f1acb8d0786c
https://research.monash.edu/en/publications/28923824-8db6-474f-b20a-2ecd39d6180d

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