Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Jennifer G. Badiang-Alberti"'
Autor:
Alex G. Waterson, Hamilton D. Dickson, Edgar R. Wood, Michael J. Reno, Thomas R. Caferro, Douglas M. Sammond, Tara Renae Rheault, Stanley D. Chamberlain, Barry R. Keith, Holly Kathleen Emerson, Jennifer G. Badiang Alberti, Robert D. Hubbard, Robert J. Griffin, David W. Rusnak, Robert J. Mullin, Krystal J. Alligood, David E. Uehling, Stephon C. Smith, Kimberly G. Petrov, Roseanne Gerding, Scott Howard Dickerson, Kirk L. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:21-26
A novel class of pyrrolidinyl-acetyleneic thieno[3,2-d]pyrimidines has been identified which potently inhibit the EGFR and ErbB-2 receptor tyrosine kinases. Synthetic modifications of the pyrrolidine carbamate moiety result in a range of effects on e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b009e9b77f5a50bba3b10df514e6c53b
https://doi.org/10.1016/j.bmcl.2008.11.023
https://doi.org/10.1016/j.bmcl.2008.11.023
Autor:
James Marvin Veal, Robert J. Griffin, Jennifer G. Badiang Alberti, Daniel J. Price, Michael J. Reno, Anne M. Hassell, Michael Robert Peel, Lisa M. Shewchuk, Victoria B. Knick, Stephen T. Davis, Laurie S. Kane-Carson, Kirk L. Stevens
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5758-5762
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependant kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280a1cb22c5d20e09331ae5b2631e585
https://doi.org/10.1016/j.bmcl.2008.09.069
https://doi.org/10.1016/j.bmcl.2008.09.069
Autor:
Jeffrey R. Jackson, Ronda G. Davis-Ward, C. Webb Andrews, Ramesh Bambal, Jennifer G. Badiang-Alberti, Tara Renae Rheault, Kelly Horne Donaldson, Mui Cheung
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(15)
Potent inhibitors of PLK1 with acceptable solubility, mouse iv clearance, and reduced CYP450 inhibition were identified. Drug-like properties were improved using a heteroaryl ring as a functional handle for manipulation of inhibitors' physiochemical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0e57818be1d878a7fa01a0e04bce7c
https://pubmed.ncbi.nlm.nih.gov/20594842
https://pubmed.ncbi.nlm.nih.gov/20594842
Autor:
Jeffrey R. Jackson, Timothy J. Lansing, Chiu Mei Sung, Mui Cheung, Mark Andrew Pobanz, Hamilton D. Dickson, Kevin Wayne Kuntz, Stanley D. Chamberlain, Kristen Elizabeth Nailor, C. Webb Andrews, Ronda G. Davis-Ward, Robert A. Mook, George Adjabeng, Jennifer G. Badiang Alberti, Keith R. Hornberger, Stephon C. Smith, Kyle A. Emmitte, Ramesh Bambal, Daniel F. Hassler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2604
Corrigendum to ‘‘Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding” [Bioorg. Med. Chem. Lett. 19 (2009) 1694] Kyle A. Emmitte *, George M. Adjabeng , C. Webb Andrews , Jennifer G. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7f9bbf14a1598bfd6d7d2085aa97650
https://doi.org/10.1016/j.bmcl.2009.01.114
https://doi.org/10.1016/j.bmcl.2009.01.114