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pro vyhledávání: '"Jennifer F. Barnhill"'
Autor:
Rachel Sterne-Marr, Jennifer F. Barnhill, John J.G. Tesmer, Rodolfo Ghirlando, Robyn M. Pyskadlo, David T. Lodowski
Publikováno v:
Biochemistry. 44:6958-6970
In response to extracellular signals, G protein-coupled receptors (GPCRs) catalyze guanine nucleotide exchange on Galpha subunits, enabling both activated Galpha and Gbetagamma subunits to target downstream effector enzymes. One target of Gbetagamma
Autor:
Jennifer F. Barnhill, Julie A. Pitcher, David T. Lodowski, W. Darrell Capel, Robert J. Lefkowitz, John J.G. Tesmer
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 59:936-939
G protein-coupled receptor kinase 2 (GRK2) phosphorylates activated G protein-coupled receptors (GPCRs), which ultimately leads to their desensitization and/or downregulation. The enzyme is recruited to the plasma membrane via the interaction of its