Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer F. Toczko"'
Autor:
Matthew Jude Sharp, Will L. Canoy, Kae M. Bullock, Eric Eugene Boros, Xiao-ming M. Zhou, Richard T. Matsuoka, Greg A. Erickson, Vassil I. Elitzin, Mark B. Mitchell, Matthew C. Salmon, David H. Igo, Nicole M. Deschamps, Daniel W. Reynolds, Andrew D. Brown, Gregory E. Peckham, Istvan Kaldor, Jennifer F. Toczko, Shannon Condon, Carpenter Andrew J, Elie Amine Tabet, Jing M. Fang, Biren K. Joshi, Lianming Michael Wu, Jeremy D. Cobb
Publikováno v:
Organic Process Research & Development. 20:1469-1475
Practical and scalable syntheses were developed that were used to prepare multikilogram batches of GSK1292263A (1) and GSK2041706A (15), two potent G protein-coupled receptor 119 (GPR119) agonists. Both syntheses employed relatively cheap and readily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82876eef78eb10aca7f33fb50ec6c1c0
https://doi.org/10.1021/acs.oprd.6b00157
https://doi.org/10.1021/acs.oprd.6b00157
Autor:
Jennifer F. Toczko, Bobby N. Glover, Mark B. Mitchell, John Corona, Kim A. Harvey, Yong Zhang, Diederich Ann M, Mark D. Trone, Kae M. Bullock, Delphilia Burton, Robert Yule
Publikováno v:
Organic Process Research & Development. 13:303-309
Two short, high-yielding routes to the selective PPARγ agonist GSK376501A were developed and carried out on scale. The key bond -forming reaction in each synthesis was the substitution of a 3,5-difluoro or 3,5-dibromo aryl intermediate with 2-methox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a98b4509886338938a891008ee2efc3
https://doi.org/10.1021/op800211c
https://doi.org/10.1021/op800211c
Autor:
Alan Millar, Jennifer F. Toczko, David M. Black, Tom C. Lovelace, Shiping Xie, Brian D. Doan, Roman Davis
Publikováno v:
Tetrahedron: Asymmetry. 19:2015-2019
An efficient highly diastereo- and enantioselective synthesis of the bis-tetrahydrofuran (bis-THF) alcohol of several HIV protease inhibitors, including Brecanavir and Darunavir, has been achieved utilizing an Evans Mukaiyama aldol reaction of (benzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c3be78b02a5330a33363ec521247281
https://doi.org/10.1016/j.tetasy.2008.07.037
https://doi.org/10.1016/j.tetasy.2008.07.037
Publikováno v:
Organic Process Research & Development. 12:896-899
A ligand−solvent−base screen was performed on a Suzuki−Miyaura coupling reaction, and the screening data, followed by a set of focused experiments, helped to optimize reaction conditions. Further work was carried out that centered on reducing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6155bc6ce95581bdc888644d7ce25c2c
https://doi.org/10.1021/op800064y
https://doi.org/10.1021/op800064y
Autor:
Jeremy D. Cobb, Bob E. Cooley, Roy C. Flanagan, Mary M. Jackson, Lynda A. Jones, Richard T. Matsuoka, Alan Millar, Daniel E. Patterson, Matthew J. Sharp, Jennifer F. Toczko, et al. et al.
Publikováno v:
ChemInform. 42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92927721dcb60bc95d05c4a028d1775c
https://doi.org/10.1002/chin.201125237
https://doi.org/10.1002/chin.201125237
Autor:
John Andrew Corfield, Bobby N. Glover, Rossella Guidetti, David Haigh, Katrina Jane Medhurst, Armel A. Agbodjan, Richard T. Matsuoka, Mary M. Jackson, Matthew J. Sharp, Royston C. B. Copley, Martin John Slater, Alan Millar, Jennifer F. Toczko, Roy C. Flanagan, Shiping Xie, Bob E. Cooley, P.D. Howes
Publikováno v:
The Journal of organic chemistry. 73(8)
A practical asymmetric synthesis of a highly substituted N-acylpyrrolidine on multi-kilogram scale is described. The key step in the construction of the three stereocenters is a [3+2] cycloaddition of methyl acrylate and an imino ester prepared from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6150abc7f90aaabfd8e5253a0e7787
https://pubmed.ncbi.nlm.nih.gov/18358046
https://pubmed.ncbi.nlm.nih.gov/18358046
Autor:
Kae M. Bullock, Delphilia Burton, John Corona, Ann Diederich, Bobby Glover, Kim Harvey, Mark B. Mitchell, Mark D. Trone, Robert Yule, Yong Zhang, Jennifer F. Toczko
Publikováno v:
Organic Process Research & Development; Mar2009, Vol. 13 Issue 2, p303-309, 7p
Publikováno v:
Organic Process Research & Development; Aug2008, Vol. 12 Issue 5, p896-899, 4p