Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jennifer Epler"'
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
GNE-900 potentiates the cytotoxicity of gemcitabine in HCT-116 isogenic variants, irrespective of NHEJ competence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9176be3998d918ce16a28d9c74b13868
https://doi.org/10.1158/1535-7163.22499412.v1
https://doi.org/10.1158/1535-7163.22499412.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
Kinase selectivity profile evaluated at 100 nM GNE-900
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ea7282ccbed01f459a1dbd7566b476
https://doi.org/10.1158/1535-7163.22499427.v1
https://doi.org/10.1158/1535-7163.22499427.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
Pharmacokinetics of GNE-900 in female CD-1 mice or male Sprague-Dawley rats.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a76a80f3a8c9336cf930119821d57f6
https://doi.org/10.1158/1535-7163.22499406.v1
https://doi.org/10.1158/1535-7163.22499406.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
Representative data from a cell-based checkpoint abrogation assay.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd48cd98df355fa624c7886bad67cd3
https://doi.org/10.1158/1535-7163.22499421.v1
https://doi.org/10.1158/1535-7163.22499421.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
GNE-900 can potentiate the cytotoxicity of gemcitabine, SN-38 and pemetrexed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966f95c36f92f3a753df6962185ea963
https://doi.org/10.1158/1535-7163.22499418.v1
https://doi.org/10.1158/1535-7163.22499418.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
Representative histograms from high content imaging studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7395c771cc88eedbc98829c6de45d980
https://doi.org/10.1158/1535-7163.22499415.v1
https://doi.org/10.1158/1535-7163.22499415.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
GNE-900 is more potent at chemopotentiation in p53 null HCT-116.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0161ba975f3754afa0838863fd637961
https://doi.org/10.1158/1535-7163.22499409.v1
https://doi.org/10.1158/1535-7163.22499409.v1
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
Checkpoint kinase 1 (ChK1) is a serine/threonine kinase that functions as a central mediator of the intra-S and G2–M cell-cycle checkpoints. Following DNA damage or replication stress, ChK1-mediated phosphorylation of downstream effectors delays ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5088c39d80b46f7e2fc0b5e70d671e78
https://doi.org/10.1158/1535-7163.c.6536136
https://doi.org/10.1158/1535-7163.c.6536136
Autor:
Shiva Malek, Peter K. Jackson, Jason Halladay, Karen Williams, Lewis Gazzard, Gary Cain, Sharon Yee, Diana Jakubiak, Kenton Wong, Judi Ramiscal, Kaska Kowanetz, Jonathan Choi, Yang Xiao, Stephen Schmidt, Marie Evangelista, Tom O'Brien, Michael Flagella, Ivana Yen, Jennifer Epler, Elizabeth Blackwood
Representative data from enzyme assays evaluating the relative potency of GNE-900 against ChK1 or ChK2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3150461efb7e85d4832ddaea9dd4efae
https://doi.org/10.1158/1535-7163.22499424.v1
https://doi.org/10.1158/1535-7163.22499424.v1
Autor:
Jonathan Choi, Stephen Schmidt, Elizabeth Blackwood, Shiva Malek, Yang Xiao, Peter K. Jackson, Lewis J. Gazzard, Sharon Yee, Judi Ramiscal, Gary Cain, Michael Flagella, Diana Jakubiak, Jennifer Epler, Kenton Wong, Jason Halladay, Karen Williams, Thomas O'Brien, Marie Evangelista, Ivana Yen, Kaska Kowanetz
Publikováno v:
Molecular Cancer Therapeutics. 12:1968-1980
Checkpoint kinase 1 (ChK1) is a serine/threonine kinase that functions as a central mediator of the intra-S and G2–M cell-cycle checkpoints. Following DNA damage or replication stress, ChK1-mediated phosphorylation of downstream effectors delays ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37852935e4d3039271ab2274751812ad
https://doi.org/10.1158/1535-7163.mct-12-1218
https://doi.org/10.1158/1535-7163.mct-12-1218
