Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jennifer E. Ward"'
Autor:
Patrick M. Pilz, Jennifer E. Ward, Wei-Ting Chang, Attila Kiss, Edward Bateh, Alokkumar Jha, Sudeshna Fisch, Bruno K. Podesser, Ronglih Liao
Publikováno v:
Circulation Research. 130:1888-1905
Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions that results in structural and functional remodeling leading to subsequent impairment of cardiac function, including either systolic dysfunction, diastolic dysfun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ae9f557975d4db19613e8c33c4120fd
https://doi.org/10.1161/circresaha.122.320246
https://doi.org/10.1161/circresaha.122.320246
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 12, Iss 849, p 849 (2020)
Pharmaceutics, MDPI, 2020, 12 (9), pp.849. ⟨10.3390/pharmaceutics12090849⟩
Pharmaceutics, Vol 12, Iss 849, p 849 (2020)
Pharmaceutics, MDPI, 2020, 12 (9), pp.849. ⟨10.3390/pharmaceutics12090849⟩
Smart engineered and naturally derived nanovesicles, capable of targeting specific tissues and cells and delivering bioactive molecules and drugs into them, are becoming important drug delivery systems. Liposomes stand out among different types of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e546473c1bf932d7e4970f662bee7e34
http://europepmc.org/articles/PMC7559099
http://europepmc.org/articles/PMC7559099
Autor:
Katharina Schimmel, Ronald M. Witteles, Michaela Liedtke, Cheng-Yu Tsai, Kevin M. Alexander, Seema Dangwal, Isabel Morgado, Ronglih Liao, Jennifer E. Ward, Alokkumar Jha, Dian J Lee
Publikováno v:
Circulation Research. 125
Amyloid light chain (AL) amyloidosis results from tissue deposition of clonal light chains, most commonly produced by clonal plasma cells. AL amyloidosis is closely associated with multiple myeloma (MM), another disease which arises from clonal plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c720a3190ea21fbe8e7ac2ebb06a393e
https://doi.org/10.1161/res.125.suppl_1.750
https://doi.org/10.1161/res.125.suppl_1.750
Autor:
Soeun Ngoy, Sudeshna Fisch, Isabel Morgado, Alessandro Evangelisti, Katharina Schimmel, Seema Dangwal, Kevin M. Alexander, Dian-Jian Lee, Jennifer E. Ward, Cheng-Yu Tsai, Ronglih Liao
Publikováno v:
Circulation Research. 125
Background: Neonatal mammalian hearts have the unique characteristic to fully repair and regenerate following injury. This discovery has led to visionary endeavors to understand and subsequently reawaken regeneration processes in the human adult hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2cb9a4638297897971a41216ce6360f
https://doi.org/10.1161/res.125.suppl_1.720
https://doi.org/10.1161/res.125.suppl_1.720
Autor:
Michal Lulu, Jonathan S. Wall, Richard V. Fisher, Ming Proschitsky, Stephen J. Kennel, Charlotte Chung, Jennifer E. Ward, Jonathan M. Levenson, Rajaraman Krishnan, Veruna Shibad
Publikováno v:
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 26(sup1)
We have previously described the discovery and development of GAIM (general amyloid interaction motif)-Ig (immunoglobulin) fusions as therapeutic candidates for neurodegenerative indications [1,2]....
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b9b5b6e8725b9f5444a6494b248d74
https://pubmed.ncbi.nlm.nih.gov/31343324
https://pubmed.ncbi.nlm.nih.gov/31343324
Autor:
Isabel Morgado, Deepa Mishra, Ronglih Liao, Shaurya Joshi, Sudeshna Fisch, Eva Buys, Deepak Mishra, Jennifer E. Ward, Shikha Mishra, Sharmila Dorbala, Calum A. MacRae, Giampaolo Merlini, Francesca Lavatelli
Publikováno v:
Am J Physiol Heart Circ Physiol
Cardiac dysfunction is the most frequent cause of morbidity and mortality in amyloid light chain (AL) amyloidosis caused by a clonal immunoglobulin light chain (LC). Previously published transgenic animal models of AL amyloidosis have not recapitulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c82b8d6d355290085c4287892516636
https://europepmc.org/articles/PMC6580397/
https://europepmc.org/articles/PMC6580397/
Autor:
Ronglih Liao, Jennifer E. Ward
Publikováno v:
Circulation research. 120(12)
Amyloidoses represent a group of human degenerative diseases characterized by the deposition of aggregates of abnormally folded proteins in single or multi-organs. Whereas neurological amyloidoses, such as Alzheimer and Parkinson disease, have receiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffd2e47f32cc8442b3d123d3f3a5039
https://pubmed.ncbi.nlm.nih.gov/28596171
https://pubmed.ncbi.nlm.nih.gov/28596171
Autor:
Hannah L. Semigran, Matthew Dai, Marc J. Semigran, Patricia A. Collins, Jennifer E. Ward, David C. Seldin, Jordan T. Shin
Publikováno v:
Amyloid. 19:191-196
AL cardiomyopathy leading to heart failure (HF) represents a significant cause of morbidity and mortality in systemic amyloidosis. However, the paucity of robust in vivo models of AL-induced cardiac dysfunction has limited our ability to probe the me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46716917c7babe484a44487fff47bb8d
https://doi.org/10.3109/13506129.2012.733741
https://doi.org/10.3109/13506129.2012.733741
Publikováno v:
Gene therapy
Amyloid light chain (AL) amyloidosis is a rare hematologic disorder characterized by the accumulation of a misfolded monoclonal immunoglobulin (Ig) light chain (LC) as fibrillar protein deposits. Current treatments, including cytotoxic chemotherapy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba31fdb2389fde218a690bf2e078930d
https://doi.org/10.1038/gt.2011.69
https://doi.org/10.1038/gt.2011.69
Autor:
Jianru Shi, Jian Guan, Bingbing Jiang, Thomas E. MacGillivray, Rodney H. Falk, Federica del Monte, Douglas B. Sawyer, Jennifer E. Ward, David C. Seldin, Marc J. Semigran, Daniel A. Brenner, Ronglih Liao, Lawreen H. Connors
Publikováno v:
Proceedings of the National Academy of Sciences. 107:4188-4193
Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d70465dfaa060f74a84fc859976dab23
https://doi.org/10.1073/pnas.0912263107
https://doi.org/10.1073/pnas.0912263107