Výsledky vyhledávání - "Jennifer E. Quinn"

Akademický článek

The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression

Autor: Jennifer E. Quinn, Myriam D. Jeninga, Katharina Limm, Kapil Pareek, Tina Meißgeier, Anna Bachmann, Michael F. Duffy, Michaela Petter

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and survival of the human malaria parasite Plasmodium (P.) falciparum. Bromodomain proteins contribute to this process by binding to acetylated lysine residues o

Externí odkaz: https://doaj.org/article/6213dcd7d9aa4c9693b81f422ea0c278

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Akademický článek

ApiAP2 Transcription Factors in Apicomplexan Parasites

Autor: Myriam D. Jeninga, Jennifer E. Quinn, Michaela Petter

Publikováno v: Pathogens, Vol 8, Iss 2, p 47 (2019)

Apicomplexan parasites are protozoan organisms that are characterised by complex life cycles and they include medically important species, such as the malaria parasite Plasmodium and the causative agents of toxoplasmosis (Toxoplasma gondii) and crypt

Externí odkaz: https://doaj.org/article/6545a389ce844aaaa65c95077b5c1ce2

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Supplementary Figure 1 from Clinicopathological Features of Homologous Recombination–Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival

Autor: Richard J. Edmondson, Nicola J. Curtin, Harriet Aneke, Perry Maxwell, W. Glenn McCluggage, Jennifer E. Quinn, Bisha Uzir, San Soohoo, Ahmed Elattar, Elizabeth R. Plummer, Asima Mukhopadhyay

PDF file - 103K, HR status and correlation with ex vivo cytotoxicity to PARP inhibitors. A, schema outlining study demontrating tight correlation between HR deficiency and sensitivity to PARP inhibitor for both epithelial EOCs and other HRD cancers b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fb380e34d55f26a47eca04577a5460
https://doi.org/10.1158/0008-5472.22391573

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Supplementary Data from BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage–Inducible Gene

Autor: D. Paul Harkin, Peter H. Watson, Patrick G. Johnston, George Reid, Paul B. Mullan, Patrick J. Morrison, Tong F. Lioe, Ethan D. Emberley, Karl Mulligan, Stephen Moore, Colin R. James, Gail E. Stewart, Jennifer E. Quinn, Julia J. Gorski, Richard D. Kennedy

Supplementary Data from BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage–Inducible Gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71294171ef069218458768d924db819f
https://doi.org/10.1158/0008-5472.22364252

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Data from Clinicopathological Features of Homologous Recombination–Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival

Autor: Richard J. Edmondson, Nicola J. Curtin, Harriet Aneke, Perry Maxwell, W. Glenn McCluggage, Jennifer E. Quinn, Bisha Uzir, San Soohoo, Ahmed Elattar, Elizabeth R. Plummer, Asima Mukhopadhyay

Up to 50% of epithelial ovarian cancers (EOC) display defects in the homologous recombination (HR) pathway. We sought to determine the ramifications of the homologous recombination–deficient (HRD) status on the clinicopathologic features, chemother

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04db783e73165b5563cb457aa17bd202
https://doi.org/10.1158/0008-5472.c.6503291.v1

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Supplementary Figure 2 from Clinicopathological Features of Homologous Recombination–Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival

Autor: Richard J. Edmondson, Nicola J. Curtin, Harriet Aneke, Perry Maxwell, W. Glenn McCluggage, Jennifer E. Quinn, Bisha Uzir, San Soohoo, Ahmed Elattar, Elizabeth R. Plummer, Asima Mukhopadhyay

PDF file - 62K, RAD51 foci and ex vivo cytotocicity in HR competent and HR deficient primary cultures A. Box plot showing cytotoxicity to 10 muM rucaparib B. Box plot showing RAD51 foci formation after 24 hr exposure to rucaparib or hydroxyurea C. Sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68434986546ecbe424e4787eeaa638db
https://doi.org/10.1158/0008-5472.22391570.v1

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Data from BRCA1 and c-Myc Associate to Transcriptionally Repress Psoriasin, a DNA Damage–Inducible Gene

Evidence is accumulating to suggest that some of the diverse functions associated with BRCA1 may relate to its ability to transcriptionally regulate key downstream target genes. Here, we identify S100A7 (psoriasin), S100A8, and S100A9, members of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a366737102b08d549f7e9bda9f06511
https://doi.org/10.1158/0008-5472.c.6494102

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Supplementary Figure Legends 1-2 from Clinicopathological Features of Homologous Recombination–Deficient Epithelial Ovarian Cancers: Sensitivity to PARP Inhibitors, Platinum, and Survival

Autor: Richard J. Edmondson, Nicola J. Curtin, Harriet Aneke, Perry Maxwell, W. Glenn McCluggage, Jennifer E. Quinn, Bisha Uzir, San Soohoo, Ahmed Elattar, Elizabeth R. Plummer, Asima Mukhopadhyay

PDF file - 70K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eecaf355db4f716b755fd809dc43d4
https://doi.org/10.1158/0008-5472.22391567

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The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite

Autor: Jennifer E, Quinn, Myriam D, Jeninga, Katharina, Limm, Kapil, Pareek, Tina, Meißgeier, Anna, Bachmann, Michael F, Duffy, Michaela, Petter

Publikováno v: Frontiers in cell and developmental biology. 10

Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and survival of the human malaria parasite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::844fa65c72078f34bc9d6cd5be12337e
https://pubmed.ncbi.nlm.nih.gov/35493110

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BRCA1 and MAD2 Are Coexpressed and Are Prognostic Indicators in Tubo-ovarian High-Grade Serous Carcinoma

Autor: Tara Byrne, Laura Nelson, James P Beirne, Tracy Robson, W. Glenn McCluggage, Jennifer E. Quinn, Fiona Furlong, Daniel J. Sharpe

Publikováno v: Byrne, T, Nelson, L, Beirne, J, Sharpe, D, Quinn, J E, Glenn McCluggage, W, Robson, T & Furlong, F 2018, ' BRCA1 and MAD2 are Co-expressed and are Prognostic Indicators in Tubo-ovarian High-grade Serous Carcinoma ', International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, vol. 28, no. 3, pp. 472-478 . https://doi.org/10.1097/IGC.0000000000001214

ObjectivesThe aim of this study was to investigate the relationship between BRCA1 and mitotic arrest deficiency protein 2 (MAD2) protein expression, as determined by immunohistochemistry, and clinical outcomes in epithelial ovarian carcinoma (EOC).Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5249daebd9b343745cb24325b4e9c6d
https://doi.org/10.1097/igc.0000000000001214

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