Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jennifer E. Kowalchick"'
Autor:
Dooseop Kim, Qiu Guo, Ying Chen, Milton L. Hammond, Xinchun Tong, Carl P. Sparrow, Amjad Ali, Denise P. Milot, Sheryl A. Hyland, Peter J. Sinclair, Samuel D. Wright, James V. Pivnichny, Julianne A. Hunt, Suoyu S. Xu, Cameron J. Smith, Florida Kallashi, Suzanne S. Eveland, You Jung Park, Matt S. Anderson, Melanie Latham, Ray Rosa, Jennifer E. Kowalchick, Anne-Marie Cumiskey, Laurence B. Peterson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:558-561
We describe structure-activity studies leading to the discovery of 2-arylbenzoxazole 3, the first in a series to raise serum high-density lipoprotein cholesterol levels in transgenic mice. Replacement of the 4-piperidinyloxy moiety with piperazinyl p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e589804421cb20d83a5fcc59bc27fcc1
https://doi.org/10.1016/j.bmcl.2010.10.062
https://doi.org/10.1016/j.bmcl.2010.10.062
Autor:
Nancy A. Thornberry, Michael H. Fisher, Dooseop Kim, Bei B. Zhang, Huaibing He, Xiaoping Zhang, Barbara Leiting, Kathryn A. Lyons, Joseph K. Wu, Emma R. Parmee, Matthew J. Wyvratt, Linda Brockunier, KellyAnn D. Pryor, Ann E. Weber, Sangita B. Patel, George J. Eiermann, Ranabir Sinha Roy, Giovanna Scapin, Aleksandr Petrov, Lan Zhu, Jennifer E. Kowalchick
Publikováno v:
Journal of Medicinal Chemistry. 51:589-602
A series of beta-aminoamides bearing triazolopiperazines have been discovered as potent, selective, and orally active dipeptidyl peptidase IV (DPP-4) inhibitors by extensive structure-activity relationship (SAR) studies around the triazolopiperazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea47e684c0a487b035f98caae89783bb
https://doi.org/10.1021/jm070330v
https://doi.org/10.1021/jm070330v
Autor:
Ann E. Weber, Reshma A. Patel, Joseph K. Wu, Aleksandr Petrov, Frank Marsilio, Jennifer E. Kowalchick, KellyAnn D. Pryor, Nancy A. Thornberry, Barbara Leiting, Kathryn A. Lyons, Giovanna Scapin, Huaibing He, George J. Eiermann, Dooseop Kim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5934-5939
Various beta-amino amides containing triazolopiperazine heterocycles have been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. These compounds display excellent oral bioavailability and good over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4b1107f9d56431f26f4262e6b4530a
https://doi.org/10.1016/j.bmcl.2007.07.100
https://doi.org/10.1016/j.bmcl.2007.07.100
Autor:
Joseph K. Wu, KellyAnn D. Pryor, Ann E. Weber, George J. Eiermann, Reshma A. Patel, Dooseop Kim, Jinyou Xu, Nancy A. Thornberry, Anthony Mastracchio, Scott D. Edmondson, Jennifer E. Kowalchick, Huaibing He, Barbara Leiting, Kathryn A. Lyons
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3373-3377
A series of beta-aminoamides bearing triazolopiperazines has been prepared and evaluated as potent, selective, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Efforts at optimization of the beta-aminoamide series, which ultimately led to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599f25f09625a28655ac50e27db98260
https://doi.org/10.1016/j.bmcl.2007.03.098
https://doi.org/10.1016/j.bmcl.2007.03.098
Autor:
Ann E. Weber, Margaret E. McCann, Lan Zhu, Matthew J. Wyvratt, Sangita B. Patel, Gerard J. Hickey, Joseph K. Wu, Jennifer E. Kowalchick, Dooseop Kim, Bei B. Zhang, George J. Eiermann, Barbara Leiting, Kathryn A. Lyons, Huaibing He, Maria G. Beconi, Frank Marsilio, Nancy A. Thornberry, Reshma A. Patel, Aleksandr Petrov, Liping Wang, Michael H. Fisher, Ranabir Sinha Roy, Giovanna Scapin
Publikováno v:
Journal of Medicinal Chemistry. 48:141-151
A novel series of beta-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of type 2 diabetes. (2R)-4-Oxo-4-[3-(trifluoromethyl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e5223c1e3153487a5459b31b6510c0
https://doi.org/10.1021/jm0493156
https://doi.org/10.1021/jm0493156
Autor:
David D. Wisnoski, Joseph M. Keane, Ahren I. Green, Jennifer E. Kowalchick, Christopher M. Micklitsch, Amy M. Galka, Chriss E. McDonald
Publikováno v:
Tetrahedron Letters. 42:163-166
A new approach to the generation of acyl radical equivalents has been developed. Treatment of amides with triflic anhydride followed by samarium diiodide allows for cyclization onto appropriately substituted olefins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1851210cfd712b469c73d5a42cbc52ab
https://doi.org/10.1016/s0040-4039(00)01919-5
https://doi.org/10.1016/s0040-4039(00)01919-5
Autor:
Ahren I. Green, David D. Wisnoski, Amy M. Galka, Joseph M. Keane, Chriss E. McDonald, Christopher M. Micklitsch, Jennifer E. Kowalchick
Publikováno v:
ChemInform. 32
A new approach to the generation of acyl radical equivalents has been developed. Treatment of amides with triflic anhydride followed by samarium diiodide allows for cyclization onto appropriately substituted olefins.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c9f119a8de82406a3c20188dfeb01b7
https://doi.org/10.1002/chin.200116060
https://doi.org/10.1002/chin.200116060
Autor:
Dooseop Kim, Jennifer E. Kowalchick, Linda L. Brockunier, Emma R. Parmee, George J. Eiermann, Michael H. Fisher, Huaibing He, Barbara Leiting, Kathryn Lyons, Giovanna Scapin, Sangita B. Patel, Aleksandr Petrov, KellyAnn D. Pryor, Ranabir Sinha Roy, Joseph K. Wu, Xiaoping Zhang, Matthew J. Wyvratt, Bei B. Zhang, Lan Zhu, Nancy A. Thornberry
Publikováno v:
Journal of Medicinal Chemistry; Jan2008, Vol. 51 Issue 3, p589-602, 14p