Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jennifer E. Klomp"'
Autor:
Andrew M. Waters, Tala O. Khatib, Bjoern Papke, Craig M. Goodwin, G. Aaron Hobbs, J. Nathaniel Diehl, Runying Yang, A. Cole Edwards, Katherine H. Walsh, Rita Sulahian, James M. McFarland, Kevin S. Kapner, Thomas S.K. Gilbert, Clint A. Stalnecker, Sehrish Javaid, Anna Barkovskaya, Kajal R. Grover, Priya S. Hibshman, Devon R. Blake, Antje Schaefer, Katherine M. Nowak, Jennifer E. Klomp, Tikvah K. Hayes, Michelle Kassner, Nanyun Tang, Olga Tanaseichuk, Kaisheng Chen, Yingyao Zhou, Manpreet Kalkat, Laura E. Herring, Lee M. Graves, Linda Z. Penn, Hongwei H. Yin, Andrew J. Aguirre, William C. Hahn, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109291- (2021)
Summary: To identify therapeutic targets for KRAS mutant pancreatic cancer, we conduct a druggable genome small interfering RNA (siRNA) screen and determine that suppression of BCAR1 sensitizes pancreatic cancer cells to ERK inhibition. Integrative a
Externí odkaz:
https://doaj.org/article/24ff658919d8494e80b28117e73c541b
Autor:
Ye S. Lee, Jennifer E. Klomp, Clint A. Stalnecker, Craig M. Goodwin, Yanzhe Gao, Gaith N. Droby, Cyrus Vaziri, Kirsten L. Bryant, Channing J. Der, Adrienne D. Cox
Publikováno v:
Genes & Cancer. 14:30-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf5c98db1c2f6adfe62574239278d9a
https://doi.org/10.18632/genesandcancer.231
https://doi.org/10.18632/genesandcancer.231
Autor:
Craig M. Goodwin, Andrew M. Waters, Jennifer E. Klomp, Sehrish Javaid, Kirsten L. Bryant, Clint A. Stalnecker, Kristina Drizyte-Miller, Bjoern Papke, Runying Yang, Amber M. Amparo, Irem Ozkan-Dagliyan, Elisa Baldelli, Valerie Calvert, Mariaelena Pierobon, Jessica A. Sorrentino, Andrew P. Beelen, Natalie Bublitz, Mareen Lüthen, Kris C. Wood, Emanuel F. Petricoin, Christine Sers, Autumn J. McRee, Adrienne D. Cox, Channing J. Der
Publikováno v:
Cancer Res
Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key genetic step that complements activation of KRAS in promoting the development and malignant growth of pancreatic ductal adenocarcinoma (PDAC). However, pharmacologic res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cab7d8277df82fc4e157bfc7db0ef82
https://doi.org/10.1158/0008-5472.can-22-0391
https://doi.org/10.1158/0008-5472.can-22-0391
Autor:
Channing J. Der, Adrienne D. Cox, Udo Rudloff, Krister Wennerberg, Brian M. Wolpin, Andrew J. Aguirre, Dhirendra K. Simanshu, Emanuel F. Petricoin, Sharon L. Campbell, Dominic Esposito, Kirsten L. Bryant, Prson Gautam, Raymond W.S. Ng, Junning Wang, Jonathan M. DeLiberty, Craig M. Goodwin, Jennifer E. Klomp, Richard G. Hodge, Bjoern Papke, J. Nathaniel Diehl, Andrew M. Waters, Andrew O. Anderson, Timothy H. Tran, Mariaelena Pierobon, Ryan D. Thurman, Anne M. Miermont, Nicole M. Baker, G. Aaron Hobbs
Structure factors and crystal information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::216f6e8c4cf83b25972bc99b461169ca
https://doi.org/10.1158/2159-8290.22535650
https://doi.org/10.1158/2159-8290.22535650
Autor:
Channing J. Der, Adrienne D. Cox, Autumn J. McRee, Christine Sers, Emanuel F. Petricoin, Kris C. Wood, Mareen Lüthen, Natalie Bublitz, Andrew P. Beelen, Jessica A. Sorrentino, Mariaelena Pierobon, Valerie Calvert, Elisa Baldelli, Irem Ozkan-Dagliyan, Amber M. Amparo, Runying Yang, Bjoern Papke, Kristina Drizyte-Miller, Clint A. Stalnecker, Kirsten L. Bryant, Sehrish Javaid, Jennifer E. Klomp, Andrew M. Waters, Craig M. Goodwin
Figure S7 page2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acddd6baeccef281cd7c89ad06c366e
https://doi.org/10.1158/0008-5472.22432947
https://doi.org/10.1158/0008-5472.22432947
Autor:
Channing J. Der, Adrienne D. Cox, Autumn J. McRee, Christine Sers, Emanuel F. Petricoin, Kris C. Wood, Mareen Lüthen, Natalie Bublitz, Andrew P. Beelen, Jessica A. Sorrentino, Mariaelena Pierobon, Valerie Calvert, Elisa Baldelli, Irem Ozkan-Dagliyan, Amber M. Amparo, Runying Yang, Bjoern Papke, Kristina Drizyte-Miller, Clint A. Stalnecker, Kirsten L. Bryant, Sehrish Javaid, Jennifer E. Klomp, Andrew M. Waters, Craig M. Goodwin
Supplementary Data and Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306f3e6cb9bdc08cf8212e98818fdca1
https://doi.org/10.1158/0008-5472.22432941
https://doi.org/10.1158/0008-5472.22432941
Autor:
Channing J. Der, Adrienne D. Cox, Autumn J. McRee, Christine Sers, Emanuel F. Petricoin, Kris C. Wood, Mareen Lüthen, Natalie Bublitz, Andrew P. Beelen, Jessica A. Sorrentino, Mariaelena Pierobon, Valerie Calvert, Elisa Baldelli, Irem Ozkan-Dagliyan, Amber M. Amparo, Runying Yang, Bjoern Papke, Kristina Drizyte-Miller, Clint A. Stalnecker, Kirsten L. Bryant, Sehrish Javaid, Jennifer E. Klomp, Andrew M. Waters, Craig M. Goodwin
Mutational loss of CDKN2A (encoding p16INK4A) tumor-suppressor function is a key genetic step that complements activation of KRAS in promoting the development and malignant growth of pancreatic ductal adenocarcinoma (PDAC). However, pharmacologic res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aac2b4a73c2414e8aceef7834205187
https://doi.org/10.1158/0008-5472.c.6514275.v1
https://doi.org/10.1158/0008-5472.c.6514275.v1
Autor:
Channing J. Der, Adrienne D. Cox, Autumn J. McRee, Christine Sers, Emanuel F. Petricoin, Kris C. Wood, Mareen Lüthen, Natalie Bublitz, Andrew P. Beelen, Jessica A. Sorrentino, Mariaelena Pierobon, Valerie Calvert, Elisa Baldelli, Irem Ozkan-Dagliyan, Amber M. Amparo, Runying Yang, Bjoern Papke, Kristina Drizyte-Miller, Clint A. Stalnecker, Kirsten L. Bryant, Sehrish Javaid, Jennifer E. Klomp, Andrew M. Waters, Craig M. Goodwin
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9063a982801a1d99eae9d4209128101a
https://doi.org/10.1158/0008-5472.22432938
https://doi.org/10.1158/0008-5472.22432938
Autor:
Jennifer E. Klomp, Jeff A. Klomp, Nathaniel J. Diehl, Cole A. Edwards, Kristina Drizyte-Miller, Priya S. Hibshman, Runying Yang, Alexis J. Morales, Khalilah E. Taylor, Mariaelena Pierobon, Emanuel F. Petricoin, Johnson L. Jared, Emily M. Huntsman, Tomer M. Yaron, Markus Vähä-Koskela, Laura E. Herring, Alex W. Prevatte, Natalie K. Barker, Lee M. Graves, Wennerberg Krister, Lewis C. Cantley, James G. Christensen, Adrienne D. Cox, Channing J. Der, Clint A. Stalnecker
Publikováno v:
Molecular Cancer Research. 21:B034-B034
Direct inhibitors of mutationally activated KRAS are currently under intense preclinical and clinical development, with one KRASG12C mutant-selective inhibitor approved. However, treatment-associated resistance to KRASG12C inhibitors has been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f377f225a46ff56c65429ebd985642
https://doi.org/10.1158/1557-3125.ras23-b034
https://doi.org/10.1158/1557-3125.ras23-b034
Publikováno v:
Biochemical Society Transactions. 49:253-267
The RAF–MEK–ERK mitogen-activated protein kinase (MAPK) cascade is aberrantly activated in a diverse set of human cancers and the RASopathy group of genetic developmental disorders. This protein kinase cascade is one of the most intensely studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ead8f0175940c7e5d5edd4f149dd55
https://doi.org/10.1042/bst20200507
https://doi.org/10.1042/bst20200507