Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Jennifer E Morgan"'
Autor:
Valentina Sardone, Matthew Ellis, Silvia Torelli, Lucy Feng, Darren Chambers, Deborah Eastwood, Caroline Sewry, Rahul Phadke, Jennifer E Morgan, Francesco Muntoni
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194540 (2018)
Clinical trials using strategies aimed at inducing dystrophin expression in Duchenne muscular dystrophy (DMD) are underway or at advanced planning stage, including splice switching antisense oligonucleotides (AON), drugs to induce read-through of non
Externí odkaz:
https://doaj.org/article/cb7c92cc16454711a4912773fe14b1a9
Autor:
Narinder Janghra, Jennifer E Morgan, Caroline A Sewry, Francis X Wilson, Kay E Davies, Francesco Muntoni, Jonathon Tinsley
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150818 (2016)
Duchenne muscular dystrophy is a severe and currently incurable progressive neuromuscular condition, caused by mutations in the DMD gene that result in the inability to produce dystrophin. Lack of dystrophin leads to loss of muscle fibres and a reduc
Externí odkaz:
https://doaj.org/article/98b5ac20b92d4c31b6d1bc807616818f
Autor:
Palittiya Sintusek, Francesco Catapano, Napat Angkathunkayul, Elena Marrosu, Simon H Parson, Jennifer E Morgan, Francesco Muntoni, Haiyan Zhou
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155032 (2016)
Gastrointestinal (GI) defects, including gastroesophageal reflux, constipation and delayed gastric emptying, are common in patients with spinal muscular atrophy (SMA). Similar GI dysmotility has been identified in mouse models with survival of motor
Externí odkaz:
https://doaj.org/article/3f82b4e1eb4343598e834c990054bf41
Autor:
Irina T Zaharieva, Mattia Calissano, Mariacristina Scoto, Mark Preston, Sebahattin Cirak, Lucy Feng, James Collins, Ryszard Kole, Michela Guglieri, Volker Straub, Kate Bushby, Alessandra Ferlini, Jennifer E Morgan, Francesco Muntoni
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80263 (2013)
Duchenne muscular Dystrophy (DMD) is an inherited disease caused by mutations in the dystrophin gene that disrupt the open reading frame, while in frame mutations result in Becker muscular dystrophy (BMD). Ullrich congenital muscular dystrophy (UCMD)
Externí odkaz:
https://doaj.org/article/cdb54c9b9c9a442188f457fbe2bcb0b6
Autor:
Luisa Boldrin, Jennifer E Morgan
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54599 (2013)
Skeletal muscle has a remarkable capability of regeneration following injury. Satellite cells, the principal muscle stem cells, are responsible for this process. However, this regenerative capacity is reduced in muscular dystrophies or in old age: in
Externí odkaz:
https://doaj.org/article/57e69f0651064134b3af407547750510
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17454 (2011)
BackgroundStem cell transplantation is a promising potential therapy for muscular dystrophies, but for this purpose, the cells need to be systemically-deliverable, give rise to many muscle fibres and functionally reconstitute the satellite cell niche
Externí odkaz:
https://doaj.org/article/fbcc0f9fe4df4cc6bd5bf00df5d41161
Autor:
Viola F Gnocchi, Juergen Scharner, Zhe Huang, Ken Brady, Jaclyn S Lee, Robert B White, Jennifer E Morgan, Yin-Biao Sun, Juliet A Ellis, Peter S Zammit
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16651 (2011)
LMNA encodes both lamin A and C: major components of the nuclear lamina. Mutations in LMNA underlie a range of tissue-specific degenerative diseases, including those that affect skeletal muscle, such as autosomal-Emery-Dreifuss muscular dystrophy (A-
Externí odkaz:
https://doaj.org/article/73e492a68abf478296efc077c4ca2123
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e24826 (2011)
A new conditionally immortal satellite cell-derived cell-line, H2K 2B4, was generated from the H2K(b)-tsA58 immortomouse. Under permissive conditions H2K 2B4 cells terminally differentiate in vitro to form uniform myotubes with a myogenic protein pro
Externí odkaz:
https://doaj.org/article/9868a3ca732548d7bdcad691c49f24f3
Autor:
Charlotte A Collins, Viola F Gnocchi, Robert B White, Luisa Boldrin, Ana Perez-Ruiz, Frederic Relaix, Jennifer E Morgan, Peter S Zammit
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4475 (2009)
Pax3 and Pax7 are paired-box transcription factors with roles in developmental and adult regenerative myogenesis. Pax3 and Pax7 are expressed by postnatal satellite cells or their progeny but are down regulated during myogenic differentiation. We now
Externí odkaz:
https://doaj.org/article/56ad7d249bae49e1bd9e9a5a5a98c38c
Autor:
Mathilde Doisy, Ophélie Vacca, Claire Fergus, Talia Gileadi, Minou Verhaeg, Amel Saoudi, Thomas Tensorer, Luis Garcia, Vincent P. Kelly, Federica Montanaro, Jennifer E. Morgan, Maaike van Putten, Annemieke Aartsma-Rus, Cyrille Vaillend, Francesco Muntoni, Aurélie Goyenvalle
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3243 (2023)
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene that disrupt the open reading frame and thus prevent production of functional dystrophin proteins. Recent advances in DMD treatment, notably exon skipping and AAV gene therapy,
Externí odkaz:
https://doaj.org/article/29a1434a711345e993444660698a38fe