Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Jennifer E, Wu"'
Autor:
Omar Khan, Sasikanth Manne, E John Wherry, Josephine R Giles, Amy E Baxter, Shin Foong Ngiow, Yinghui Jane Huang, Simone L Park, Jennifer E Wu
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/dda59d50efd34eaf8e85bec76f4672ea
Autor:
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A. Oldridge, Josephine R. Giles, Jennifer E. Wu, Zeyu Chen, Yinghui Jane Huang, Jonathan Belman, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Charles S. Abrams, E. John Wherry, Sharon Adamski, Zahidul Alam, Mary M. Addison, Katelyn T. Byrne, Aditi Chandra, Hélène C. Descamps, Nicholas Han, Yaroslav Kaminskiy, Shane C. Kammerman, Justin Kim, Jacob T. Hamilton, Nune Markosyan, Julia Han Noll, Dalia K. Omran, Eric Perkey, Elizabeth M. Prager, Dana Pueschl, Austin Rennels, Jennifer B. Shah, Jake S. Shilan, Nils Wilhausen, Ashley N. Vanderbeck
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflamm
Externí odkaz:
https://doaj.org/article/f380b6f884834140a346b9249d88cbb6
Autor:
Josephine R. Giles, Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang, Ryan Staupe, Mohamed S. Abdel-Hakeem, Hua Huang, Divij Mathew, Mark M. Painter, Jennifer E. Wu, Yinghui Jane Huang, Rishi R. Goel, Patrick K. Yan, Giorgos C. Karakousis, Xiaowei Xu, Tara C. Mitchell, Alexander C. Huang, E. John Wherry
Publikováno v:
Nature Immunology. 23:1600-1613
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::277752491a42aa61ea5003f33b68b30f
https://doi.org/10.1038/s41590-022-01338-4
https://doi.org/10.1038/s41590-022-01338-4
Autor:
Jennifer E. Wu, Sasikanth Manne, Shin Foong Ngiow, Amy E. Baxter, Hua Huang, Elizabeth Freilich, Megan L. Clark, Joanna H. Lee, Zeyu Chen, Omar Khan, Ryan P. Staupe, Yinghui J. Huang, Junwei Shi, Josephine R. Giles, E. John Wherry
Publikováno v:
bioRxiv
Identifying novel molecular mechanisms of exhausted CD8 T cells (Tex) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation ofin vivoTexcan be costly and inefficient.In vitromodels of Texare eas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41ec6b7f1a1cbd79f8e158021783d81
https://europepmc.org/articles/PMC10153201/
https://europepmc.org/articles/PMC10153201/
Autor:
Divij Mathew, Laura A. Vella, Randall A. Oyer, Jedd D. Wolchok, James Robinson, Cécile Alanio, Susan DeWolf, Kara N. Maxwell, Amy E. Baxter, Erin Bange, Karan Naik, Scott E. Hensley, Justin Kim, Anita Kumar, Tara Perloff, Adam J Widman, Madison E. Weirick, Santosha Vardhana, Madeline A Hwee, Florence Porterfield, Derek A. Oldridge, Krista R Budzik, Samuel J Kerr, Justine V. Cohen, Nicholas Han, Josephine R. Giles, Christopher M McAllister, Ariel R. Weisman, Michael Galantino, Angela DeMichele, Ivan Maillard, Charlotte Roberts, Caroline A. G. Ittner, Paul Wileyto, Ronac Mamtani, Lova Sun, Susan Tollett, Jennifer E. Wu, Olutosin Owoyemi, Sharon Adamski, John P. Reilly, Alexander C. Huang, Sigrid Gouma, Ryan Massa, Allison R. Greenplate, Sawsan R. Boutemine, E. John Wherry, Heather M. Giannini, Tiffanie K. Jones, Carla Wright, Olutwatosin Oniyide, Emily M. Kugler, N. Esther Babady, Alfred L. Garfall, Peter Maslak, Robert H. Vonderheide, Cathy Zheng, R.S. Agyekum, Nuala J. Meyer, Thomas G. Dunn
Publikováno v:
Nature Medicine. 27:1280-1289
Patients with cancer have high mortality from coronavirus disease 2019 (COVID-19), and the immune parameters that dictate clinical outcomes remain unknown. In a cohort of 100 patients with cancer who were hospitalized for COVID-19, patients with hema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953c384aa17e1a2d15af5f6dd7fec305
https://doi.org/10.1038/s41591-021-01386-7
https://doi.org/10.1038/s41591-021-01386-7
Autor:
Josephine R. Giles, Shin Foong Ngiow, Sasikanth Manne, Amy E. Baxter, Omar Khan, Ping Wang, Ryan Staupe, Mohamed S. Abdel-Hakeem, Hua Huang, Divij Mathew, Mark M. Painter, Jennifer E. Wu, Yinghui Jane Huang, Rishi Goel, E. John Wherry
Naïve CD8 T cells can differentiate into effector (TEFF), memory (TMEM), or exhausted (TEX) CD8 T cells. These developmental pathways are associated with distinct transcriptional and epigenetic changes that endow cells with different functional capa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c322ce5cfd2736b15eb1ae9bcae8808b
https://doi.org/10.1101/2022.03.27.485974
https://doi.org/10.1101/2022.03.27.485974
Autor:
Michael T. Werner, Jennifer E. Wu, Wei Xu, Patrick Yan, Giorgos C. Karakousis, Bertram Bengsch, Kunal P. Patel, Alexander C. Huang, Jonathan Kaye, Shelley L. Berger, Sasikanth Manne, Tara C. Mitchell, Omar Khan, Ryan P. Staupe, John Attanasio, Sierra McDonald, Xiaowei Xu, Sangeeth M. George, Shin Foong Ngiow, Josephine R. Giles, Ravi K. Amaravadi, Lynn M. Schuchter, E. John Wherry, Katherine A. Alexander, Greg Donahue
Publikováno v:
Nature
Exhausted CD8+ T (Tex) cells in chronic infections and cancer have limited effector function, high co-expression of inhibitory receptors and extensive transcriptional changes compared with effector (Teff) or memory (Tmem) CD8+ T cells. Tex cells are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06523d18f9ba6a20715fea1effb9f40
http://europepmc.org/articles/PMC6713202
http://europepmc.org/articles/PMC6713202
Autor:
Jeanette Dougherty, Sasikanth Manne, Amy E. Baxter, Josephine R. Giles, Yinghui Jane Huang, Ajinkya Pattekar, Oliva Kuthuru, Jennifer E. Wu, Aae Suzuki, Nuala J. Meyer, Debora Dunbar, Zeyu Chen, Alexander C. Huang, Ariel R. Weisman, Allison R. Greenplate, Mortimer Poncz, Charles S. Abrams, Ian Frank, Liang Zhao, Caroline A. G. Ittner, Mohamed S. Abdel-Hakeem, Amrita Sarkar, Rishi R. Goel, Sigrid Gouma, Divij Mathew, Sokratis A. Apostolidis, John P. Reilly, Derek A. Oldridge, Cécile Alanio, Scott E. Hensley, Laura A. Vella, E. John Wherry, Heather M. Giannini, Lubica Rauova, Brittany Weiderhold
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality in patients infected with SARS-CoV-2. Severe COVID-19 has been associated with hyperinflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b8c501dfe82e024f027c6827feee13
https://doi.org/10.1101/2021.05.01.442279
https://doi.org/10.1101/2021.05.01.442279
Autor:
Eileen C. Goodwin, Peyton Conrey, Divij Mathew, E. John Wherry, Heather M. Giannini, Cécile Alanio, Kevin O McNerney, Leticia Kuri-Cervantes, Marcus J. Bolton, Josephine R. Giles, Sigrid Gouma, Samir Sayed, Laura A. Vella, Jessica H. Lee, Julie Chase, Oliva Kuthuru, Claudia P. Arevalo, Scott E. Hensley, Zeyu Chen, Chakkapong Burudpakdee, Sarah E. Henrickson, Derek A. Oldridge, Amy E. Baxter, David T. Teachey, Kurt D'Andrea, Andre Ramos, Caroline Diorio, Hamid Bassiri, Nuala J. Meyer, Elizabeth M. Anderson, M. Betina Pampena, Edward M. Behrens, Yinghui Jane Huang, Sokratis A. Apostolidis, Madison E. Weirick, Jennifer E. Wu, Alexander C. Huang, Cristina Jasen, Michael R. Betts
Publikováno v:
Science Immunology
medRxiv
medRxiv
MIS-C is defined by lymphocyte activation, including elevated plasmablast frequencies and marked activation of CX3CR1+ CD8+ T cells.
Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder dis
Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aae17e62fdca1922b58e545291702f3
http://europepmc.org/articles/PMC8128303
http://europepmc.org/articles/PMC8128303
Autor:
Lova Sun, Derek A. Oldridge, Thomas G. Dunn, M. Galantino, Ronac Mamtani, T. Perloff, Anita Kumar, Nicholas Han, Nuala J. Meyer, Peter Maslak, C. Roberts, Santosha Vardhana, Ariel R. Weisman, Caroline A. G. Ittner, Adam J Widman, Randall A. Oyer, E. Wherry, S. Kerr, Divij Mathew, Angela DeMichele, Christopher M McAllister, Amy E. Baxter, Ivan Maillard, C. Wright, Jedd D. Wolchok, James Robinson, Justine V. Cohen, Cécile Alanio, Susan DeWolf, Allison R. Greenplate, K. Budzik, Kara N. Maxwell, Scott E. Hensley, N. E. Babady, Josephine R. Giles, Madison E. Weirick, Justin Kim, K. Naik, Sawsan R. Boutemine, Laura A. Vella, Sharon Adamski, Jennifer E. Wu, Florence Porterfield, Alexander C. Huang, Ryan Massa, S. Tollett, Alfred L. Garfall, Sigrid Gouma, Emily M. Kugler, Heather M. Giannini, Tiffanie K. Jones, Oluwatosin Oniyide, John P. Reilly, Erin Bange, R.S. Agyekum, E. P. Wileyto, Olutosin Owoyemi, Robert H. Vonderheide, Cathy Zheng
Cancer patients have increased morbidity and mortality from Coronavirus Disease 2019 (COVID-19), but the underlying immune mechanisms are unknown. In a cohort of 100 cancer patients hospitalized for COVID-19 at the University of Pennsylvania Health S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::343bff30d7eb38b79dc0033a8c420d20
https://doi.org/10.21203/rs.3.rs-162289/v1
https://doi.org/10.21203/rs.3.rs-162289/v1