Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jennifer E, Koblinski"'
Autor:
Julia E. Altman, Amy L. Olex, Emily K. Zboril, Carson J. Walker, David C. Boyd, Rachel K. Myrick, Nicole S. Hairr, Jennifer E. Koblinski, Madhavi Puchalapalli, Bin Hu, Mikhail G. Dozmorov, X. Steven Chen, Yunshun Chen, Charles M. Perou, Brian D. Lehmann, Jane E. Visvader, J. Chuck Harrell
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 10, Pp n/a-n/a (2024)
Abstract Background Breast cancer's complex transcriptional landscape requires an improved understanding of cellular diversity to identify effective treatments. The study of genetic variations among breast cancer subtypes at single‐cell resolution
Externí odkaz:
https://doaj.org/article/d0c391dda0a74b8395d749dfd6add293
Autor:
Gene Chatman Clark, James David Hampton, Jennifer E. Koblinski, Bridget Quinn, Sitara Mahmoodi, Olga Metcalf, Chunqing Guo, Erica Peterson, Paul B. Fisher, Nicholas P. Farrell, Xiang-Yang Wang, Ross B. Mikkelsen
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Despite recent advances in radiotherapeutic strategies, acquired resistance remains a major obstacle, leading to tumor recurrence for many patients. Once thought to be a strictly cancer cell intrinsic property, it is becoming increasingly clear that
Externí odkaz:
https://doaj.org/article/f282329de9d04973b8f6e3130a15ad63
Autor:
Konstantinos V. Floros, Sheeba Jacob, Richard Kurupi, Carter K. Fairchild, Bin Hu, Madhavi Puchalapalli, Jennifer E. Koblinski, Mikhail G. Dozmorov, Sosipatros A. Boikos, Maurizio Scaltriti, Anthony C. Faber
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-13 (2021)
Abstract Human epidermal growth factor receptor 2 gene (HER2) is focally amplified in approximately 20% of breast cancers. HER2 inhibitors alone are not effective, and sensitizing agents will be necessary to move away from a reliance on heavily toxic
Externí odkaz:
https://doaj.org/article/38b772c2e3b047a0a0603783709c7fe0
Autor:
Dongdong Wang, Nayden G. Naydenov, Mikhail G. Dozmorov, Jennifer E. Koblinski, Andrei I. Ivanov
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-19 (2020)
Abstract Background Breast cancer metastasis is driven by a profound remodeling of the cytoskeleton that enables efficient cell migration and invasion. Anillin is a unique scaffolding protein regulating major cytoskeletal structures, such as actin fi
Externí odkaz:
https://doaj.org/article/794fdb2e1cee441da925c54454ac1cd0
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101581- (2020)
Summary: Prolactin (PRL) and its receptor (PRLr) play important roles in the pathogenesis of breast cancer. Cyclophilin A (CypA) is a cis-trans peptidyl-prolyl isomerase (PPI) that is constitutively associated with the PRLr and facilitates the activa
Externí odkaz:
https://doaj.org/article/357c4368c7e745d39914248ba66ae654
Autor:
Madhavi Puchalapalli, Liang Mu, Chevaunne Edwards, Benjamin Kaplan-Singer, Pearl Eni, Kiran Belani, David Finkelstein, Arpan Patel, Megan Sayyad, Jennifer E. Koblinski
Publikováno v:
Analytical Cellular Pathology, Vol 2019 (2019)
Breast cancer is one of the most common forms of cancer affecting women in the United States, second only to skin cancers. Although treatments have been developed to combat primary breast cancer, metastasis remains a leading cause of death. An early
Externí odkaz:
https://doaj.org/article/1024d60fa3404aa4bc27dbc495854190
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Biological importance of Gab1 in HNSCC cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1755ff52a1c2abd42395916bda423b
https://doi.org/10.1158/2767-9764.22545726.v1
https://doi.org/10.1158/2767-9764.22545726.v1
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Preclinical and clinical studies have evidenced that effective targeted therapy treatment designed against receptor tyrosine kinases (RTKs) in different solid tumor paradigms is predicated on simultaneous inhibition of both the PI3K and MEK intracell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024b6b35f0eff8644abf41336ecc088a
https://doi.org/10.1158/2767-9764.c.6551016.v1
https://doi.org/10.1158/2767-9764.c.6551016.v1
Autor:
Anthony C. Faber, Cyril H. Benes, Mikhail G. Dozmorov, Devraj Basu, Iain M. Morgan, Yue Sun, Hisashi Harada, Jennifer E. Koblinski, Sosipatros A. Boikos, Maninderjit S. Ghotra, Krista M. Dalton, Patricia Greninger, Ellen Murchie, Regina K. Egan, Giovanna Stein Crowther, Rishabh Khatri, Colin M. Coon, Madhavi Puchalapalli, Bin Hu, Jinyang Cai, Ayesha T. Chawla, Sheeba Jacob, Konstantinos V. Floros, Richard Kurupi
Cell line information and SHP099 screen data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5661eba48fd98960c0399d013483bf
https://doi.org/10.1158/2767-9764.22545723
https://doi.org/10.1158/2767-9764.22545723
Autor:
Anthony C. Faber, Cyril H. Benes, Sosipatros A. Boikos, Mikhail G. Dozmorov, Jennifer E. Koblinski, Yuki Kato Maves, Mayuri Shende, Marissa L. Calbert, Maninderjit S. Ghotra, Richard Kurupi, Timothy L. Lochmann, Sheeba Jacob, Daniel A.R. Heisey
GSK-J4 inhibits histone demethylation of EWS-FLI1 target genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28114b6be5d650979ebaf6db9a1e3a7f
https://doi.org/10.1158/1535-7163.22521064
https://doi.org/10.1158/1535-7163.22521064