Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jennifer E, Davoren"'
Autor:
Rouba Kozak, Tamás Kiss, Keith Dlugolenski, David E. Johnson, Roxanne R. Gorczyca, Kyle Kuszpit, Brian D. Harvey, Polina Stolyar, Stacey J. Sukoff Rizzo, William E. Hoffmann, Dmitri Volfson, Mihaly Hajós, Jennifer E. Davoren, Amanda L. Abbott, Graham V. Williams, Stacy A. Castner, David L. Gray
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists
Externí odkaz:
https://doaj.org/article/0f0c6a051bdf46babdb1a3b0bfe553ab
Autor:
Graham V. Williams, Jennifer E. Davoren, Dmitri Volfson, David Gray, Mihály Hajós, Kyle Kuszpit, Tamás Kiss, William E. Hoffmann, Brian D. Harvey, Roxanne R Gorczyca, Stacey J. Sukoff Rizzo, David E. Johnson, Amanda L. Abbott, Keith Dlugolenski, Stacy A. Castner, Polina Stolyar, Rouba Kozak
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology
Frontiers in Pharmacology
Selective activation of dopamine D1 receptors remains a promising pro-cognitive therapeutic strategy awaiting robust clinical investigation. PF-6142 is a key example from a recently disclosed novel series of non-catechol agonists and partial agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5b478619938cf5d883f9410506abde
https://www.frontiersin.org/article/10.3389/fphar.2020.01005/full
https://www.frontiersin.org/article/10.3389/fphar.2020.01005/full
Autor:
Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
Publikováno v:
Journal of Medicinal Chemistry. 60:6649-6663
Recent data demonstrated that activation of the muscarinic M1 receptor by a subtype-selective positive allosteric modulator (PAM) contributes to the gastrointestinal (GI) and cardiovascular (CV) cholinergic adverse events (AEs) previously attributed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16d6e6b4f8608876f69c7501545a8c8
https://doi.org/10.1021/acs.jmedchem.7b00597
https://doi.org/10.1021/acs.jmedchem.7b00597
Autor:
Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen
Publikováno v:
Biochemistry. 55:7073-7085
The rationale for using M1 selective muscarinic acetylcholine receptor activators for the treatment of cognitive impairment associated with psychiatric and neurodegenerative disease is well-established in the literature. Here, we investigate measurem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d948042e32f463780f579df4556d74
https://doi.org/10.1021/acs.biochem.6b00688
https://doi.org/10.1021/acs.biochem.6b00688
Autor:
Deborah L. Smith, Sarah J. Neal, Lei Zhang, Jeremy R. Edgerton, Jennifer E. Davoren, Sarah Grimwood, John T. Lazzaro, Chewah Lee
Publikováno v:
Molecular Pharmacology. 90:177-187
Selective activation of the M1 muscarinic acetylcholine receptor (mAChR) via a positive allosteric modulator (PAM) is a new approach for the treatment of the cognitive impairments associated with schizophrenia and Alzheimer's disease. Herein, we desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a4cbb153c3abcd01cb4427f9543370
https://doi.org/10.1124/mol.116.104737
https://doi.org/10.1124/mol.116.104737
Autor:
Jotham Wadsworth Coe, Brajesh K. Rai, Sidney Liang, Keith Dlugolenski, Jennifer E. Davoren, Erik Alphie Lachapelle, Rebecca E. O’Connor, Deane M. Nason, Christine C. Orozco, David Gray, Rouba Kozak, Christopher John Helal, Brian Samas, Yue Liu, Michelle A. Salafia, Anthony R. Harris, Wenjian Xu
Publikováno v:
Journal of medicinal chemistry. 61(24)
The discovery of D1 subtype-selective agonists with drug-like properties has been an enduring challenge for the greater part of 40 years. All known D1-selective agonists are catecholamines that bring about receptor desensitization and undergo rapid m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b084e9e7a5c6d066edd7c22acfa061cd
https://pubmed.ncbi.nlm.nih.gov/30431269
https://pubmed.ncbi.nlm.nih.gov/30431269
Autor:
Ludivine Moine, Bruce N. Rogers, Mark L. Weber, Karen Tse, Sheri L. Snow, Susan E. Drozda, Karen Baker, John A. Lowe, Kevin A. Serpa, Katherine Schuyten, Jennifer E. Davoren, Rong Suobao, Ann S. Wright, Shari L. DeNinno, Michelle Marie Claffey, Allen J. Duplantier, Christopher Ryan Butler, Brian P. Boscoe, Alan J. Clark, Polina Stolyar, Robert J. Mather, Lois K. Chenard, Haojing Rong, Gaurav Arora, Matthew R. Reese, Tammy Whisman, Lei Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4941-4944
Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in controlling spontaneous electrical activity during epileptic seizures. In an effort to identify a compound with suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d5703f96a7e503af07e95a710ca422
https://doi.org/10.1016/j.bmcl.2015.04.074
https://doi.org/10.1016/j.bmcl.2015.04.074
Autor:
Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
Publikováno v:
Journal of medicinal chemistry. 60(15)
Recent data demonstrated that activation of the muscarinic M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29248df43dd90a74489fbab479a9cfba
https://pubmed.ncbi.nlm.nih.gov/28598634
https://pubmed.ncbi.nlm.nih.gov/28598634
Autor:
Michael, Popiolek, David P, Nguyen, Veronica, Reinhart, Jeremy R, Edgerton, John, Harms, Susan M, Lotarski, Stefanus J, Steyn, Jennifer E, Davoren, Sarah, Grimwood
Publikováno v:
Biochemistry. 55(51)
The rationale for using M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::385a83d5d30f6dd8dc8ed05cdb55a4c3
https://pubmed.ncbi.nlm.nih.gov/27958713
https://pubmed.ncbi.nlm.nih.gov/27958713
Autor:
Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris
Publikováno v:
Journal of medicinal chemistry. 59(13)
It is hypothesized that selective muscarinic M1 subtype activation could be a strategy to provide cognitive benefits to schizophrenia and Alzheimer's disease patients while minimizing the cholinergic side effects observed with nonselective muscarinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fc61159c2c41b46e640509efcd4086
https://pubmed.ncbi.nlm.nih.gov/27275946
https://pubmed.ncbi.nlm.nih.gov/27275946