Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jennifer Doudna"'
Autor:
Rahul K. Suryawanshi, Taha Y. Taha, Maria McCavitt-Malvido, Ines Silva, Mir M. Khalid, Abdullah M. Syed, Irene P. Chen, Prachi Saldhi, Bharath Sreekumar, Mauricio Montano, Kafaya Foresythe, Takako Tabata, G. Renuka Kumar, Alicia Sotomayor-Gonzalez, Venice Servellita, Amelia Gliwa, Jenny Nguyen, Noah Kojima, Teresa Arellanor, Aallyah Bussanich, Victoria Hess, Maria Shacreaw, Lauren Lopez, Matthew Brobeck, Fred Turner, Yuzhu Wang, Sydney Ghazarian, Gregg Davis, Diviana Rodriguez, Jennifer Doudna, Lee Spraggon, Charles Y. Chiu, Melanie Ott
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
The emergence of SARS-CoV-2 recombinants is of particular concern as they can result in a sudden increase in immune evasion due to antigenic shift. Recent recombinants XBB and XBB.1.5 have higher transmissibility than previous recombinants such as
Externí odkaz:
https://doaj.org/article/312588b304fb40aebfd425ebdbee0658
Autor:
Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima Hidalgo-Reyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Anti-CRISPR proteins offer the means of regulating CRISPR-Cas9 activity. Here the authors present the structure and biochemical characterisation of AcrIIC2 Nme alone and in complex with Cas9.
Externí odkaz:
https://doaj.org/article/e4066aeabab14fe3b824f6c38d4f8d8d
Autor:
Joshua Cofsky, Jennifer Doudna
Publikováno v:
Bio-Protocol, Vol 10, Iss 20 (2020)
Biochemical investigations into DNA-binding and DNA-cutting proteins often benefit from the specific attachment of a radioactive label to one of the two DNA termini. In many cases, it is essential to perform two versions of the same experiment: one w
Externí odkaz:
https://doaj.org/article/3467423c9226402fbfe13556c58dcee6
Autor:
Jennifer Doudna
Publikováno v:
Molecular Frontiers Journal, Vol 1, Iss 2, Pp 76-91 (2017)
CRISPR-Cas9 is a revolutionary genome-editing tool. Understanding how Cas9 recognizes DNA and how to control its function will be critical in improving the system. We used single-molecule FRET to elucidate a key validation step during DNA target reco
Externí odkaz:
https://doaj.org/article/15f728f0dafa47da83ed96ca573dd9b2
Autor:
Judd F. Hultquist, Kathrin Schumann, Jonathan M. Woo, Lara Manganaro, Michael J. McGregor, Jennifer Doudna, Viviana Simon, Nevan J. Krogan, Alexander Marson
Publikováno v:
Cell Reports, Vol 17, Iss 5, Pp 1438-1452 (2016)
Summary: New genetic tools are needed to understand the functional interactions between HIV and human host factors in primary cells. We recently developed a method to edit the genome of primary CD4+ T cells by electroporation of CRISPR/Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/c5e4f90fd3b349c0bf28cdd2cec6c482
Publikováno v:
eLife, Vol 2 (2013)
Type II CRISPR immune systems in bacteria use a dual RNA-guided DNA endonuclease, Cas9, to cleave foreign DNA at specific sites. We show here that Cas9 assembles with hybrid guide RNAs in human cells and can induce the formation of double-strand DNA
Externí odkaz:
https://doaj.org/article/048712f7a3c54e74a1be3594f16bfea1
Autor:
Jennifer Doudna, Julianna LeMieux
Publikováno v:
GEN Biotechnology. 1:415-420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c26028a13ec58310e9602e6deab17a9
https://doi.org/10.1089/genbio.2022.29059.jdo
https://doi.org/10.1089/genbio.2022.29059.jdo
Autor:
Yue Clare Lou, Ben Rubin, Marie Schoelmerich, Kaden DiMarco, Adair Borges, Rachel Rovinsky, Leo Song, Jennifer Doudna, Jillian Banfield
Human milk oligosaccharides (HMOs) ensure proper infant gut microbiome establishment. Isolate studies have revealed the genetic basis for HMO metabolism, but they exclude the possibility of HMO assimilation via synergistic interactions involving mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0025da89ea8964cb3c9f51c99d6d3dbc
https://doi.org/10.21203/rs.3.rs-2743153/v1
https://doi.org/10.21203/rs.3.rs-2743153/v1
Autor:
Venice Servellita, Abdullah M. Syed, Noah Brazer, Prachi Saldhi, Miguel Garcia-Knight, Bharath Sreekumar, Mir M. Khalid, Alison Ciling, Pei-Yi Chen, G. Renuka Kumar, Amelia S. Gliwa, Jenny Nguyen, Alicia Sotomayor-Gonzalez, Yueyuan Zhang, Edwin Frias, John Prostko, John Hackett, Raul Andino, Jennifer Doudna, Melanie Ott, Charles Y. Chiu
SummaryVirus-like particle (VLP) and live virus assays were used to investigate neutralizing immunity to Delta and Omicron SARS-CoV-2 variants in 239 samples from 125 fully vaccinated individuals. In uninfected, non-boosted individuals, VLP neutraliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75bf6a440ecd9c3681cce4af5909be53
https://doi.org/10.1101/2022.01.25.22269794
https://doi.org/10.1101/2022.01.25.22269794
Autor:
Doudna J; Jennifer Doudna is the executive director of the Innovative Genomics Institute, a Howard Hughes Medical Institute investigator, and holds the Li Ka Shing Chancellor's Chair in Biomedical and Health Sciences at the University of California at Berkeley, California, USA. She is also a senior investigator at the Gladstone Institutes, San Francisco, California, USA. doudna@berkeley.edu.
Publikováno v:
Science (New York, N.Y.) [Science] 2019 Nov 15; Vol. 366 (6467), pp. 777.