Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jennifer Dolkas"'
Autor:
Swathi K. Hullugundi, Jennifer Dolkas, Andrei V. Chernov, Tony L. Yaksh, Kelly A. Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y. Strongin, Patrick M. Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I. Shubayev
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 38, Iss , Pp 100757- (2024)
Background: A bioactive myelin basic protein (MBP) fragment, comprising MBP84-104, is released in sciatic nerve after chronic constriction injury (CCI). Intraneural injection (IN) of MBP84-104 in an intact sciatic nerve is sufficient to induce persis
Externí odkaz:
https://doaj.org/article/8207210de5484313ba8d5ab4ba1522be
Autor:
Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows pe
Externí odkaz:
https://doaj.org/article/7c2bdb3688594f509a6640ace50c6ee8
Autor:
Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Mila Angert, Andrei V. Chernov, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-10 (2018)
Abstract Background In the peripheral nerve, pro-inflammatory matrix metalloproteinase (MMP)-9 performs essential functions in the acute response to injury. Whether MMP-9 activity contributes to late-phase injury or whether MMP-9 expression or activi
Externí odkaz:
https://doaj.org/article/30adcbf9c51b40b2b607997ec78589a7
Autor:
Youngsoon Kim, Albert G Remacle, Andrei V Chernov, Huaqing Liu, Igor Shubayev, Calvin Lai, Jennifer Dolkas, Sergey A Shiryaev, Vladislav S Golubkov, Andrew P Mizisin, Alex Y Strongin, Veronica I Shubayev
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33664 (2012)
BACKGROUND:Myelinating Schwann cells (mSCs) form myelin in the peripheral nervous system. Because of the works by us and others, matrix metalloproteinase-9 (MMP-9) has recently emerged as an essential component of the Schwann cell signaling network d
Externí odkaz:
https://doaj.org/article/c0941fa2d18e43aebe9d6c08a9cef7d4
Publikováno v:
EMBO reports. 23(6)
Human coronaviruses have been recently implicated in neurological sequelae by insufficiently understood mechanisms. We here identify an amino acid sequence within the HCoV-OC43 p65-like protein homologous to the evolutionarily conserved motif of myel
Autor:
Hee Jong Lee, Albert G. Remacle, Swathi K. Hullugundi, Jennifer Dolkas, Jake B. Leung, Andrei V. Chernov, Tony L. Yaksh, Alex Y. Strongin, Veronica I. Shubayev
Publikováno v:
Frontiers in cellular neuroscience. 16
Immunotherapy holds promise as a non-addictive treatment of refractory chronic pain states. Increasingly, sex is recognized to impact immune regulation of pain states, including mechanical allodynia (pain from non-painful stimulation) that follows pe
Autor:
Veronica I. Shubayev, Albert G. Remacle, Jake Leung, Hee Jong Lee, Jennifer Dolkas, Alex Y. Strongin, Swathi K. Hullugundi, Tony L. Yaksh, Andrei V. Chernov
Background: Autoantibodies, a hallmark of autoimmune disorders, are thought to contribute to the pathogenesis of chronic pain. Mechanical hypersensitivity is a severe complication of peripheral nerve injury mediated through sex-specific activity of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c575af0e3111de8ada5c3d40e27a5808
https://doi.org/10.21203/rs.3.rs-117432/v1
https://doi.org/10.21203/rs.3.rs-117432/v1
Autor:
Brian P. James, Mila Angert, Swathi K. Hullugundi, Albert G. Remacle, Andrei V. Chernov, Veronica I. Shubayev, Alex Y. Strongin, Tony L. Yaksh, Jennifer Dolkas, Kelly A. Eddinger
Publikováno v:
J Biol Chem
In the peripheral nerve, mechanosensitive axons are insulated by myelin, a multilamellar membrane formed by Schwann cells. Here, we offer first evidence that a myelin degradation product induces mechanical hypersensitivity and global transcriptomics
Autor:
Albert G. Remacle, Piotr Cieplak, Jennifer Dolkas, Andrei V. Chernov, Veronica I. Shubayev, Mila Angert, Swathi K. Hullugundi, Alex Y. Strongin, David Scott
Publikováno v:
Biochemical Journal. 475:2355-2376
In demyelinating nervous system disorders, myelin basic protein (MBP), a major component of the myelin sheath, is proteolyzed and its fragments are released in the neural environment. Here, we demonstrated that, in contrast with MBP, the cellular upt
Autor:
Veronica I. Shubayev, Swathi K. Hullugundi, Alex Y. Strongin, Albert G. Remacle, Jennifer Dolkas, Andrei V. Chernov, R. Carter W. Jones, Mila Angert
Publikováno v:
Journal of Immunological Methods. 455:80-87
Sciatic nerve chronic constriction injury (CCI) in rodents produces nerve demyelination via proteolysis of myelin basic protein (MBP), the major component of myelin sheath. Proteolysis releases the cryptic MBP epitope, a demyelination marker, which i