Výsledky vyhledávání - "Jennifer DeVecchio"

Akademický článek

MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma

Autor: Dechen Fu, Luke Pfannenstiel, Abeba Demelash, Yee Peng Phoon, Cameron Mayell, Claudia Cabrera, Caini Liu, Junjie Zhao, Josephine Dermawan, Deepa Patil, Jennifer DeVecchio, Matthew Kalady, Andrew J. Souers, Darren C. Phillips, Xiaoxia Li, Brian Gastman

Publikováno v: Cell Death and Disease, Vol 13, Iss 1, Pp 1-11 (2022)

Abstract Colorectal cancer (CRC) is one of the most common and deadliest forms of cancer. Myeloid Cell Leukemia 1 (MCL1), a pro-survival member of the Bcl-2 protein family is associated with chemo-resistance in CRC. The ability of MCL1 to inhibit apo

Externí odkaz: https://doaj.org/article/01cae53eba704978aeba5dc6a974721f

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Akademický článek

A Multimodal Approach to Discover Biomarkers for Taxane-Induced Peripheral Neuropathy (TIPN): A Study Protocol

Autor: Anukriti Sharma PhD, Ken B. Johnson MD, Bihua Bie MD, PhD, Emily E. Rhoades PhD, Alper Sen MD, Yuri Kida MS, Jennifer Hockings PharmD, PhD, Alycia Gatta BS, Jacqueline Davenport MS, Connie Arcangelini BS, Jennifer Ritzu BS, Jennifer DeVecchio BS, Ron Hughen BS, Mei Wei MD, G. Thomas Budd MD, N. Lynn Henry MD, Charis Eng MD, PhD, Joseph Foss MD, Daniel M. Rotroff PhD

Publikováno v: Technology in Cancer Research & Treatment, Vol 21 (2022)

Introduction: Taxanes are a class of chemotherapeutics commonly used to treat various solid tumors, including breast and ovarian cancers. Taxane-induced peripheral neuropathy (TIPN) occurs in up to 70% of patients, impacting quality of life both duri

Externí odkaz: https://doaj.org/article/2f61e6efc01a47469603cde26a8719e5

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Akademický článek

RBP4-STRA6 Pathway Drives Cancer Stem Cell Maintenance and Mediates High-Fat Diet-Induced Colon Carcinogenesis

Autor: Sheelarani Karunanithi, Liraz Levi, Jennifer DeVecchio, George Karagkounis, Ofer Reizes, Justin D. Lathia, Matthew F. Kalady, Noa Noy

Publikováno v: Stem Cell Reports, Vol 9, Iss 2, Pp 438-450 (2017)

Summary: The transmembrane protein, STRA6, functions as a vitamin A transporter and a cytokine receptor when activated by vitamin A-bound serum retinol binding protein 4 (RBP4). STRA6 activation transduces a JAK2-STAT3 signaling cascade and promotes

Externí odkaz: https://doaj.org/article/d1c98fad0f794fb09a80a97892fe5918

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Akademický článek

Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells.

Autor: Tapati Mazumdar, Ranjodh Sandhu, Maha Qadan, Jennifer DeVecchio, Victoria Magloire, Akwasi Agyeman, Bibo Li, Janet A Houghton

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75253 (2013)

The Hedgehog (HH) signaling pathway is critical for normal embryonic development, tissue patterning and cell differentiation. Aberrant HH signaling is involved in multiple human cancers. HH signaling involves a multi-protein cascade activating the GL

Externí odkaz: https://doaj.org/article/80debe48a46b46d2bcc2feb9df6e996c

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Akademický článek

cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.

Autor: Ting Shi, Tapati Mazumdar, Jennifer Devecchio, Zhong-Hui Duan, Akwasi Agyeman, Mohammad Aziz, Janet A Houghton

Publikováno v: PLoS ONE, Vol 5, Iss 10 (2010)

Hedgehog (HH) signaling plays a critical role in normal cellular processes, in normal mammalian gastrointestinal development and differentiation, and in oncogenesis and maintenance of the malignant phenotype in a variety of human cancers. Increasing

Externí odkaz: https://doaj.org/article/85d9a6aee6bd46bb9214b0faa03211d8

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