Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jennifer Daugherty"'
Autor:
Meiyu Geng, Qiuming Pan, Qingfeng Zhu, H. Eric Xu, Min Huang, Jing Ai, Yang Xu, Jennifer Daugherty-Holtrop, Xihua Yue, Siyun Xu, Yi Chen, Jian Ding, Ruiyu Zhou, Jing Li, Yuanzheng He, Qingjuan Tang, Yan-lin Wu, Jia Fan, Xin Gao, Feng Teng
Publikováno v:
JNCI Journal of the National Cancer Institute
Background Expression of the polymeric immunoglobulin receptor (pIgR), a transporter of polymeric IgA and IgM, is commonly increased in response to viral or bacterial infections, linking innate and adaptive immunity. Abnormal expression of pIgR in ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d269aacba28044da9c1b8c29a9154b
http://europepmc.org/articles/PMC3216966
http://europepmc.org/articles/PMC3216966
Autor:
Neal Rosen, David Wenkert, George F. Vande Woude, Jennifer Daugherty-Holtrop, Jiyuan Ke, Hanan Omar, Qian Xie, Greg Cavey, Edwin Chen, Yuehai Shen, Ryan W. Thompson, Robert D. Bradley, Yong Xu, H. Eric Xu, Robert Wondergem
Publikováno v:
Proceedings of the National Academy of Sciences. 108:4105-4110
Geldanamycin and its derivative 17AAG [17-(Allylamino)-17-demethoxygeldanamycin, telatinib] bind selectively to the Hsp90 chaperone protein and inhibit its function. We discovered that these drugs associate with mitochondria, specifically to the mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adff53395044b075ad8ad2928143d78c
https://doi.org/10.1073/pnas.1015181108
https://doi.org/10.1073/pnas.1015181108
Autor:
Ermanno Gherardi, H. Eric Xu, Jennifer Daugherty-Holtrop, W. David Tolbert, George F. Vande Woude
Publikováno v:
Proceedings of the National Academy of Sciences; Vol 107
Hepatocyte growth factor (HGF) is an activating ligand of the Met receptor tyrosine kinase, whose activity is essential for normal tissue development and organ regeneration but abnormal activation of Met has been implicated in growth, invasion, and m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce64e92b9fa433c0902016a04db23df0
Autor:
Jose Toro, George F. Vande Woude, Brian Cao, Eric Hudson, Ernst Lengyel, Sandra Cottingham, Troy A. Giambernardi, Ermanno Gherardi, Aviva P. Ventura, Rick V. Hay, Beatrice S. Knudsen, Eric J. Kort, Milton D. Gross, Richard A. West, Bree Berghuis, Jennifer Daugherty, Eric Xu, Tessa Grabinski, R. Scot Skinner, Qian Xie, James H. Resau, Ping Zhao
Publikováno v:
Applied Immunohistochemistry & Molecular Morphology; Vol 17
The inappropriate expression of the c-MET cell surface receptor in many human solid tumors necessitates the development of companion diagnostics to identify those patients who could benefit from c-MET targeted therapies. Tumor tissues are formalin-fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e82e04ce95f2cbb0641ce5670c4c9f0
https://doi.org/10.1097/pai.0b013e3181816ae2
https://doi.org/10.1097/pai.0b013e3181816ae2
Autor:
H. Eric Xu, Cindy K. Miranti, George F. Vande Woude, Ermanno Gherardi, W. David Tolbert, Qian Xie, Jennifer Daugherty, Chong-Feng Gao
Publikováno v:
Proceedings of the National Academy of Sciences. 104:14592-14597
Hepatocyte growth factor (HGF) activates the Met receptor tyrosine kinase by binding and promoting receptor dimerization. Here we describe a mechanistic basis for designing Met antagonists based on NK1, a natural variant of HGF containing the N-termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67126107e8be56f331ac090febf09e97
https://doi.org/10.1073/pnas.0704290104
https://doi.org/10.1073/pnas.0704290104
Autor:
H. Eric Xu, Kelly Suino, Yong Li, Jennifer Daugherty, Amanda Kovach, Mihwa Choi, Steven A. Kliewer
Publikováno v:
Proceedings of the National Academy of Sciences. 102:9505-9510
The functional interaction between the orphan nuclear receptors small heterodimer partner (SHP) and liver receptor homolog 1 (LRH-1), where SHP binds to LRH-1 and represses its constitutive transcriptional activity, is crucial for regulating genes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003fc68b97bee18e6c03da5732740541
https://doi.org/10.1073/pnas.0501204102
https://doi.org/10.1073/pnas.0501204102
Autor:
H. Eric Xu, Kelly Suino, Amanda Kovach, Steven A. Kliewer, Nathan C. Bingham, Jennifer Daugherty, Yong Li, Mihwa Choi, Greg Cavey
Publikováno v:
Molecular Cell. 17(4):491-502
The orphan nuclear receptor steroidogenic factor 1 (SF-1) regulates the differentiation and function of endocrine glands. Although SF-1 is constitutively active in cell-based assays, it is not known whether this transcriptional activity is modulated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab490638e93b3dd4b5a0e6f497c53b4