Programming of Stress-Sensitive Neurons and Circuits by Early-Life Experiences

Autor: Jessica L. Bolton, Annabel Katherine Short, Kristina A. Simeone, Jennifer Daglian, Tallie Z. Baram

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 13 (2019)

Early-life experiences influence brain structure and function long-term, contributing to resilience or vulnerability to stress and stress-related disorders. Therefore, understanding the mechanisms by which early-life experiences program specific brai

Externí odkaz: https://doaj.org/article/77aaefbdf0c94112899cc1a5e131022f

Vascular topology is acutely impacted by experimental febrile status epilepticus

Autor: Arjang Salehi, Sirus Salari, Jennifer Daglian, Kevin Chen, Tallie Z. Baram, Andre Obenaus

Febrile status epilepticus (FSE) is an important risk factor for temporal lobe epilepsy and early identification is vital. In a rat model of FSE, we identified an acute novel MRI signal in the basolateral amygdala (BLA) at 2 hours post FSE that predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eb42d67f7098dfaee17dcb2486553c2
https://doi.org/10.1101/2022.01.10.475698

Benzisothiazolinone Derivatives as Potent Allosteric Monoacylglycerol Lipase Inhibitors That Functionally Mimic Sulfenylation of Regulatory Cysteines

Autor: Kasper D. Rand, Marco Mor, Caterina Carmi, Michele Bassi, Ingvar R. Möller, Emmanuel Y. Dotsey, Daniele Piomelli, Alessio Lodola, Faizy Ahmed, Don Wei, Nephi Stella, Federica Vacondio, Jennifer Daglian, Simar Singh, Riccardo Castelli, Silvia Rivara, Mattia Anselmi, Kwang-Mook Jung, Stefano Vezzosi, Laura Scalvini, Francesca Ferlenghi

Publikováno v: Journal of Medicinal Chemistry. 63:1261-1280

We describe a set of benzisothiazolinone (BTZ) derivatives that are potent inhibitors of monoacylglycerol lipase (MGL), the primary degrading enzyme for the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Structure-activity relationship studies ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8277a61af224aae7f113809e9fc629
https://doi.org/10.1021/acs.jmedchem.9b01679

Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus

Autor: Tallie Z. Baram, Megan M. Garcia-Curran, Gissell A Sanchez, Jennifer Daglian, Alicia M. Hall, Renhao Luo, Kevin D Chen

Publikováno v: Epilepsia, vol 62, iss 3
Epilepsia

ObjectiveProlonged fever-induced seizures (febrile status epilepticus [FSE]) during early childhood increase the risk for later epilepsy, but the underlying mechanisms are incompletely understood. Experimental FSE (eFSE) in rats successfully models h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb25cad677935da7d746346628b44d9
https://escholarship.org/uc/item/5fh370dp

A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice

Autor: Dandan Li, Jennifer Daglian, Kwang-Mook Jung, Don Wei, DaYeon Lee, Daniele Piomelli

Publikováno v: Wei, D; Lee, D; Li, D; Daglian, J; Jung, K-M; & Piomelli, D. (2016). A role for the endocannabinoid 2-arachidonoyl-sn-glycerol for social and high-fat food reward in male mice. PSYCHOPHARMACOLOGY, 233(10), 1911-1919. doi: 10.1007/s00213-016-4222-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5c38t9p2

The endocannabinoid system is an important modulator of brain reward signaling. Investigations have focused on cannabinoid (CB1) receptors, because dissection of specific contributions of individual endocannabinoids has been limited by the available

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe37ce0568daadf79d58f923642077ae
https://doi.org/10.1007/s00213-016-4222-0