Výsledky vyhledávání - "Jennifer D. Spencer"

Reference intervals for thyroid hormones on Advia Centaur derived from three reference populations and a review of the literature

Autor: Ahai Luvai, Jennifer D Spencer, Julian H. Barth, Stephen Goodall

Publikováno v: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 53:385-389

Introduction Laboratories are recommended to determine their own local reference intervals (RIs) to embrace the variations in local populations. We have assessed local RIs for thyroid function tests using two different approaches to selection of refe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a63de4fe2ddf10aee46fe20d0a41997f
https://doi.org/10.1177/0004563216636897

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Regulation of Pigmentation in Human Epidermal Melanocytes by Functional High-Affinity β-Melanocyte-Stimulating Hormone/Melanocortin-4 Receptor Signaling

Autor: Jennifer D. Spencer, Karin U. Schallreuter

Publikováno v: Endocrinology. 150:1250-1258

To date, the principal receptor considered to regulate human pigmentation is the melanocortin-1 receptor (MC1-R) via induction of the cAMP/protein kinase A pathway by the melanocortins α-MSH and ACTH. In this context, it is noteworthy that β-MSH ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727eba0a454adcacc2ca065f032d38be
https://doi.org/10.1210/en.2008-1212

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Estrogens Can Contribute to Hydrogen Peroxide Generation and Quinone-Mediated DNA Damage in Peripheral Blood Lymphocytes from Patients with Vitiligo

Autor: Diana Anderson, Bhaven Chavan, Jennifer D. Spencer, John M. Wood, Karin U. Schallreuter, Angela Panske, Georgia Chiuchiarelli, Eduardo Cemeli, Hartmut Rokos, Souna M. Elwary, Johanna M. Gillbro

Publikováno v: Journal of Investigative Dermatology. 126(5):1036-1042

To date there is ample in vivo and in vitro evidence for increased epidermal and systemic hydrogen peroxide (H 2 O 2 ) levels in vitiligo, which can be reduced with a topical application of a pseudocatalase-K.U. Schallreuter (PC-KUS) leading to the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962384f166677d6d0282111e5784fddd

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Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus

Autor: Bhaven Chavan, Jennifer D. Spencer, John M. Wood, Karin U. Schallreuter, Carsten Zothner, Johanna M. Gillbro, Katharina Rübsam

Publikováno v: Biochemical and Biophysical Research Communications. 342:145-152

Oxidation of methionine residues by reactive oxygen (ROS) in protein structures leads to the formation of methionine sulfoxide which can consequently lead to a plethora of impaired functionality. The generation of methionine sulfoxide yields ultimate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9364f4b237d25fbeda4101f381346003
https://doi.org/10.1016/j.bbrc.2006.01.124

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Significant immediate and long-term improvement in quality of life and disease coping in patients with vitiligo after group climatotherapy at the Dead Sea

Autor: Jennifer D. Spencer, Giorgia Chiuchiarelli, Christian Krüger, Karin U. Schallreuter, Angela Panske, Sybille Hasse, Jim W Smythe

Publikováno v: Acta dermato-venereologica. 91(2)

Quality of life in patients with vitiligo is impaired. This study explored the immediate effect of 20 days of climatotherapy at the Dead Sea on quality of life, coping with the disease, general well-being and individual stress levels in a group of 71

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2028c8d1ae89dc239a6677440352bab
https://pubmed.ncbi.nlm.nih.gov/21240455

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Cholesterol regulates melanogenesis in human epidermal melanocytes and melanoma cells

Autor: Bhaven Chavan, Hartmut Rokos, Jennifer D. Spencer, Mohamed Shalbaf, John M. Wood, Sybille Hasse, Karin U. Schallreuter

Publikováno v: Experimental dermatology. 18(8)

Cholesterol is important for membrane stability and is the key substrate for the synthesis of steroid hormones and vitamin D. Furthermore, it is a major component of the lipid barrier in the stratum corneum of the human epidermis. Considering that st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc97b8d6a822b2cff4e38cbd21652034
https://pubmed.ncbi.nlm.nih.gov/19469904

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Regulation of melanogenesis--controversies and new concepts

Autor: Sonal Kothari, Karin U. Schallreuter, Jennifer D. Spencer, Bhaven Chavan

Publikováno v: Experimental dermatology. 17(5)

Despite many efforts, regulation of skin and hair pigmentation is still not fully understood. This article focuses mainly on controversial aspects in pigment cell biology which have emerged over the last decade. The central role of tyrosinase as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b6d67e41557d336fc7c999cd711cd4
https://pubmed.ncbi.nlm.nih.gov/18177348

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The Ca2+-binding capacity of epidermal furin is disrupted by H2O2-mediated oxidation in vitiligo

Autor: Jennifer D. Spencer, Karin U. Schallreuter, Nicholas C.J. Gibbons, Markus Böhm

Publikováno v: Endocrinology. 149(4)

The Ca(2+)-dependent precursor convertase furin is abundantly expressed in epidermal keratinocytes and melanocytes. In this context, it is noteworthy that proopiomelanocortin (POMC) cleavage is also processed by furin, leading to ACTH, beta-lipotropi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f70ccfa4e759689df2bb7b9559f682a
https://pubmed.ncbi.nlm.nih.gov/18174282

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