Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jennifer D. Noonan"'
Autor:
Duncan J. Berger, Thomas Crellen, Poppy H. L. Lamberton, Fiona Allan, Alan Tracey, Jennifer D. Noonan, Narcis B. Kabatereine, Edridah M. Tukahebwa, Moses Adriko, Nancy Holroyd, Joanne P. Webster, Matthew Berriman, James A. Cotton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Schistosomiasis control strategies rely on mass drug administration (MDA) using praziquantel. Here, Berger et al. perform whole-genome sequencing of larvae from infected children across Ugandan regions with differing MDA histories. They find extensiv
Externí odkaz:
https://doaj.org/article/c962db34a2b7473d882bdf56bb9ca5af
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112380- (2022)
Background and purpose: Nematode glutamate-gated chloride channels (GluCls) are targets of ivermectin (IVM) and moxidectin (MOX), structurally dissimilar macrocyclic lactone (ML) anthelmintics. IVM and MOX possess different pharmacokinetics and effic
Externí odkaz:
https://doaj.org/article/1b3af54ce56a4b5186c33e55045e1396
Autor:
Jennifer D Noonan, Robin N Beech
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010962 (2022)
Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in Xenopus laevis oocytes. The homomeric ACR-16 nicotine sensitive acetylcholine receptors (N-
Externí odkaz:
https://doaj.org/article/80c5440af64e414f8cfcb5a4ee12662f
Autor:
Jennifer D. Noonan, Robin N. Beech
Nicotinic acetylcholine receptors (N-AChRs) mediate fast synaptic signalling and are members of the pentameric ligand-gated ion channel (pLGIC) family. They rely on a network of accessory proteinsin vivofor correct formation and transport to the cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d343d654b363449b22afa6f0a82cbebf
https://doi.org/10.1101/2023.01.22.525060
https://doi.org/10.1101/2023.01.22.525060
Autor:
Narcis B. Kabatereine, James Cotton, Fiona Allan, Matthew Berriman, Alan Tracey, Nancy Holroyd, Joanne P. Webster, Jennifer D. Noonan, Poppy H. L. Lamberton, Duncan Berger, Moses Adriko, Thomas Crellen, Edridah M. Tukahebwa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Control and elimination of the parasitic disease schistosomiasis relies on mass administration of praziquantel. Whilst these programmes reduce infection prevalence and intensity, their impact on parasite transmission and evolution is poorly understoo
Autor:
Jennifer D. Noonan, Robin N. Beech
Neurotransmission is an important target for anthelmintic drugs, where receptor characteristics and response can be examined through reconstitution ex vivo in Xenopus laevis oocytes. The homomeric ACR-16 nicotine sensitive acetylcholine receptors (N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40fdcfd7a033be01831171ea95ccdf40
https://doi.org/10.1101/2022.06.01.493574
https://doi.org/10.1101/2022.06.01.493574
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss, Pp 112380-(2022)
Background and purpose Nematode glutamate-gated chloride channels (GluCls) are targets of ivermectin (IVM) and moxidectin (MOX), structurally dissimilar macrocyclic lactone (ML) anthelmintics. IVM and MOX possess different pharmacokinetics and effica
Autor:
Nancy Holroyd, Roz Laing, Faye H. Rodgers, Stephen R. Doyle, Geetha Sankaranarayanan, Alan Tracey, Michael Paulini, James Cotton, John S. Gilleard, Janneke Wit, Matthew Berriman, Karen Brooks, Kevin L. Howe, Collette Britton, David J. Bartley, Guillaume Sallé, Kirsty Maitland, Jennifer D. Noonan, Wojtek Bazant, Elizabeth Redman, Eileen Devaney, Axel Martinelli, Robin N. Beech, Neil Sargison, Muhammad Zubair Shabbir, Helen Beasley, Michael A. Quail, Umer Chaudhry
Publikováno v:
Communications Biology
Communications Biology, Nature Publishing Group, 2020, 3 (1), 16 p. ⟨10.1038/s42003-020-01377-3⟩
Communications Biology, Vol 3, Iss 1, Pp 1-16 (2020)
Doyle, S R, Tracey, A, Laing, R, Holroyd, N E, Bartley, D, Bazant, W, Beasley, H, Beech, R N, Britton, C, Brooks, K, Chaudhry, U N, Maitland, K, Martinelli, A, Noonan, J, Paulini, M, Quail, M A, Redman, E, Rodgers, F H, Sallé, G, Shabbir, M Z, Sankaranarayanan, G, Wit, J, Howe, K L, Sargison, N, Devaney, E, Berriman, M, Gilleard, J S & Cotton, J A 2020, ' Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm ', Communications biology . https://doi.org/10.1038/s42003-020-01377-3
Communications Biology, Nature Publishing Group, 2020, 3 (1), 16 p. ⟨10.1038/s42003-020-01377-3⟩
Communications Biology, Vol 3, Iss 1, Pp 1-16 (2020)
Doyle, S R, Tracey, A, Laing, R, Holroyd, N E, Bartley, D, Bazant, W, Beasley, H, Beech, R N, Britton, C, Brooks, K, Chaudhry, U N, Maitland, K, Martinelli, A, Noonan, J, Paulini, M, Quail, M A, Redman, E, Rodgers, F H, Sallé, G, Shabbir, M Z, Sankaranarayanan, G, Wit, J, Howe, K L, Sargison, N, Devaney, E, Berriman, M, Gilleard, J S & Cotton, J A 2020, ' Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm ', Communications biology . https://doi.org/10.1038/s42003-020-01377-3
Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-specific traits among a wider group of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204220c63dff3a92fbe0b1e10f542dc3
https://eprints.gla.ac.uk/229108/1/229108.pdf
https://eprints.gla.ac.uk/229108/1/229108.pdf
Autor:
Stephen R. Doyle, Alan Tracey, Roz Laing, Nancy Holroyd, David Bartley, Wojtek Bazant, Helen Beasley, Robin Beech, Collette Britton, Karen Brooks, Umer Chaudhry, Kirsty Maitland, Axel Martinelli, Jennifer D. Noonan, Michael Paulini, Michael A. Quail, Elizabeth Redman, Faye H. Rodgers, Guillaume Sallé, Muhammad Zubair Shabbir, Geetha Sankaranarayanan, Janneke Wit, Kevin L. Howe, Neil Sargison, Eileen Devaney, Matthew Berriman, John S. Gilleard, James A. Cotton
BackgroundHaemonchus contortusis a globally distributed and economically important gastrointestinal pathogen of small ruminants, and has become the key nematode model for studying anthelmintic resistance and other parasite-specific traits among a wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bc7f127ca146bc820fd0e2f1f93639
https://doi.org/10.1101/2020.02.18.945246
https://doi.org/10.1101/2020.02.18.945246