Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jennifer D. Irvine"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3382-3385
As part of a program to develop better PTP1B fluorogenic substrates that more closely mimic the functionality found in the natural substrate, we have prepared and evaluated nine novel analogs of 4-methylumbelliferone phosphate (MUP) with a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32acc80b0974e5c4d7965b7840bdb44
https://doi.org/10.1016/j.bmcl.2008.04.021
https://doi.org/10.1016/j.bmcl.2008.04.021
Autor:
Larry Jang, Xianfeng Li, M. Nuria De Francisco, Steven W. Ferla, J. Russell Grove, Siqun Zhou, Jennifer D. Irvine, Yijun Pan, Caiding Xu, Joy A. Miguel, Natalie Macher, Ashok Bhandari, Christopher P. Holmes, Claire M. Moody, Brian Troy Frederick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2719-2724
We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has been replaced by potential bioisosteric replacements. Several mono- or di-charged compounds (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b2e335bf814e75cabe54aa2bb86c94
https://doi.org/10.1016/j.bmcl.2008.03.007
https://doi.org/10.1016/j.bmcl.2008.03.007
Autor:
J. Russell Grove, Claire M. Moody, Xianfeng Li, Jennifer D. Irvine, Steven W. Ferla, Siqun Zhou, Larry Jang, Joy A. Miguel, Caiding Xu, Brian Troy Frederick, Ashok Bhandari, Yijun Pan, Christopher P. Holmes, Natalie Macher, M. Nuria De Francisco
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
A series of novel sulfonamides containing a single difluoromethylene-phosphonate group were discovered to be potent inhibitors of protein tyrosine phosphatase 1B. Structure–activity relationships around the scaffold were investigated, leading to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb846b06d0d8cf78ef9246c0ae0210d
https://pubmed.ncbi.nlm.nih.gov/16046123
https://pubmed.ncbi.nlm.nih.gov/16046123