Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Jennifer D. Black"'
Autor:
Neha Zutshi, Bhopal C. Mohapatra, Pinaki Mondal, Wei An, Benjamin T. Goetz, Shuo Wang, Sicong Li, Matthew D. Storck, David F. Mercer, Adrian R. Black, Sarah P. Thayer, Jennifer D. Black, Chi Lin, Vimla Band, Hamid Band
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109912- (2024)
Summary: Receptor tyrosine kinases (RTKs) control stem cell maintenance vs. differentiation decisions. Casitas B-lineage lymphoma (CBL) family ubiquitin ligases are negative regulators of RTKs, but their stem cell regulatory roles remain unclear. Her
Externí odkaz:
https://doaj.org/article/768c3a8058a948e9abfe75334d310948
Autor:
Shelby M. Knoche, Gabrielle L. Brumfield, Benjamin T. Goetz, Bailee H. Sliker, Alaina C. Larson, Madeline T. Olson, Brittany J. Poelaert, Audrey Bavari, Ying Yan, Jennifer D. Black, Joyce C. Solheim
Publikováno v:
PLoS ONE, Vol 17, Iss 9 (2022)
The histone deacetylase (HDAC) inhibitor vorinostat, used with gemcitabine and other therapies, has been effective in treatment of experimental models of pancreatic cancer. In this study, we demonstrated that M344, an HDAC inhibitor, is efficacious a
Externí odkaz:
https://doaj.org/article/73750ac5a7f441279396590b9213e24f
Autor:
Alice H. Hsu, Michelle A. Lum, Kang-Sup Shim, Peter J. Frederick, Carl D. Morrison, Baojiang Chen, Subodh M. Lele, Yuri M. Sheinin, Takiko Daikoku, Sudhansu K. Dey, Gustavo Leone, Adrian R. Black, Jennifer D. Black
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 655-669 (2018)
Summary: Protein kinase C (PKC) isozymes are commonly recognized as oncoproteins based on their activation by tumor-promoting phorbol esters. However, accumulating evidence indicates that PKCs can be inhibitory in some cancers, with recent findings p
Externí odkaz:
https://doaj.org/article/70af1efa537b465a82f8857a0e61398f
Autor:
Neha Zutshi, Bhopal C. Mohapatra, Pinaki Mondal, Wei An, Benjamin T. Goetz, Shuo Wang, Sicong Li, Matthew D. Storck, David F. Mercer, Adrian R. Black, Sarah P. Thayer, Jennifer D. Black, Chi Lin, Vimla Band, Hamid Band
Publikováno v:
bioRxiv
SUMMARYAmong the signaling pathways that control the stem cell self-renewal and maintenance vs. acquisition of differentiated cell fates, those mediated by receptor tyrosine kinase (RTK) activation are well established as key players. CBL family ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b01a912287f759bc2ea932ce30cf047f
https://europepmc.org/articles/PMC10245689/
https://europepmc.org/articles/PMC10245689/
Autor:
Katie L Bailey, Ekta Agarwal, Sanjib Chowdhury, Jiangtao Luo, Michael G Brattain, Jennifer D Black, Jing Wang
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176096 (2017)
In this study, we have uncovered a novel crosstalk between TGFβ and IGF-1R signaling pathways. We show for the first time that expression and activation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFβ/Smad3 signaling. Loss or attenuation
Externí odkaz:
https://doaj.org/article/3f173dc0e49440b4af85f1016da7630d
Autor:
Jian Li, Cheng-Hsun Chen, Katelyn L. O’Neill, Valerie J. Fousek-Schuller, Adrian R. Black, Jennifer D. Black, Jingjing Zhang, Xu Luo
Publikováno v:
The Journal of biological chemistry.
Aurora Kinases (AURK) are mitotic kinases important for regulating cell cycle progression. Small molecule inhibitors of AURK have shown promising antitumor effects in multiple cancers; however, the utility of these inhibitors as inducers of cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c64fd38f35e3f0efa01f44c2f15b0883
https://pubmed.ncbi.nlm.nih.gov/36621626
https://pubmed.ncbi.nlm.nih.gov/36621626
Autor:
Xinyue Li, Navneet Kaur, Mustafa Albahrani, Adam R. Karpf, Adrian R. Black, Jennifer D. Black
Publikováno v:
Journal of Biological Chemistry. 299:103017
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de8121554d9637bf3198cbeb9d397d69
https://doi.org/10.1016/j.jbc.2023.103017
https://doi.org/10.1016/j.jbc.2023.103017
Autor:
Michelle A. Lum, Kayla A. Jonas-Breckenridge, Adrian R. Black, Nicholas T. Woods, Caitlin O’Connor, Rita A. Avelar, Analisa DiFeo, Goutham Narla, Jennifer D. Black
Dysregulation of cap-dependent translation is a hallmark of cancer, with key roles in supporting the transformed phenotype. The eIF4E binding proteins (4E-BP1, 2, 3) are major negative regulators of cap-dependent translation that are inactivated in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb77ae725a6959e976e92b6e6699575c
https://doi.org/10.1101/2022.05.24.493272
https://doi.org/10.1101/2022.05.24.493272
Autor:
Jennifer D. Black, Chandrakanth Are, Premila D. Leiphrakpam, Sanjib Chowdhury, Lynette M. Smith, Audrey J. Lazenby, Michael G. Brattain, Michelle Mathiesen, Jing Wang
Publikováno v:
J Surg Oncol
Background Na+ /H+ exchanger regulatory factor 1 (NHERF1) has been implicated in the tumorigenesis of several cancer types and is a potential therapeutic target. The current study evaluated the relationship between NHERF1 expression and clinical outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3544ea53dc685b60b0b1867b580cca3f
https://doi.org/10.1002/jso.25805
https://doi.org/10.1002/jso.25805
Publikováno v:
The Journal of biological chemistry. 298(7)
We have previously shown that the serine/threonine kinase PKCα triggers MAPK/ERK kinase (MEK)-dependent G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d82c3583a6aeca3314bd06200debfc5
https://pubmed.ncbi.nlm.nih.gov/35697074
https://pubmed.ncbi.nlm.nih.gov/35697074