Versatile Diphosphine Chelators for Radiolabeling Peptides with 99mTc and 64Cu

Autor: Ingebjørg N. Hungnes, Truc Thuy Pham, Charlotte Rivas, James A. Jarvis, Rachel E. Nuttall, Saul M. Cooper, Jennifer D. Young, Philip J. Blower, Paul G. Pringle, Michelle T. Ma

Publikováno v: Hungnes, I N, Pham, T T, Rivas, C, Jarvis, J A, Nuttall, R E, Cooper, S M, Young, J D, Blower, P J, Pringle, P G & Ma, M T 2023, ' Versatile Diphosphine Chelators for Radiolabeling Peptides with 99m Tc and 64 Cu ', INORGANIC CHEMISTRY . https://doi.org/10.1021/acs.inorgchem.3c00426

We have developed a diphosphine (DP) platform for radiolabeling peptides with 99mTc and 64Cu for molecular SPECT and PET imaging, respectively. Two diphosphines, 2,3-bis(diphenylphosphino)maleic anhydride (DPPh) and 2,3-bis(di-p-tolylphosphino)maleic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2a2532dce84760d7f69e0f108b2acb
https://doi.org/10.1021/acs.inorgchem.3c00426

The Management Impact of 68Gallium-Tris(Hydroxypyridinone) Prostate Specific Membrane Antigen (68Ga-THP-PSMA) PET-CT Imaging for High-Risk and Biochemically Recurrent Prostate Cancer

Autor: Simon M. Hughes, Victoria Warbey, Stephen Morris, Victoria Gibson, Ben Challacombe, Prokar Dasgupta, Gary Cook, Paul Cathcart, Andrew Mallia, Meghana Kulkarni, Rick Popert, Ajay Aggarwal, Christian T. A. Brown, Jennifer D. Young

Publikováno v: Kulkarni, M, Hughes, S, Mallia, A, Gibson, V, Young, J, Aggarwal, A, Morris, S, Challacombe, B, Popert, R, Brown, C, Cathcart, P, Dasgupta, P, Warbey, V S & Cook, G J R 2020, ' The Management Impact of 68 Gallium-Tris(Hydroxypyridinone) Prostate Specific Membrane Antigen (68Ga-THP-PSMA) PET-CT Imaging for High-Risk and Biochemically Recurrent Prostate Cancer ', European Journal of Nuclear Medicine and Molecular Imaging, vol. 47, no. 3, pp. 674–686 . https://doi.org/10.1007/s00259-019-04643-7

Purpose To determine the impact on clinical management of patients with high-risk (HR) prostate cancer at diagnosis and patients with biochemical recurrence (BCR) using a new kit form of 68Ga-prostate-specific membrane antigen (PSMA), namely tris(hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e795e9a96ffac5c59d712102287a3841
https://kclpure.kcl.ac.uk/en/publications/4ffee528-fa73-4ebe-af71-e59b06949402

Cold Kit for Prostate-Specific Membrane Antigen (PSMA) PET Imaging: Phase 1 Study of 68Ga-Tris(Hydroxypyridinone)-PSMA PET/CT in Patients with Prostate Cancer

Autor: Shankar Siva, Amir Iravani, Michael S Hofman, Emily Hong, Gregory E. D. Mullen, Rodney J. Hicks, Catherine Mitchell, Jennifer D. Young, Price Jackson, David Binns, Peter Eu, Philip J. Blower, Declan G. Murphy

Publikováno v: Journal of Nuclear Medicine. 59:625-631

68Ga-labeled urea-based inhibitors of the prostate-specific membrane antigen (PSMA), such as 68Ga-labeled N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid (HBED)-PSMA-11, are promising small molecules for targeting prostate cancer. A new r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf3dccdcff94f25530584bb7466f7b84
https://doi.org/10.2967/jnumed.117.199554

The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator

Autor: Margaret S. Cooper, Andrew Cakebread, Michelle T. Ma, Jennifer D. Young, Ruslan Cusnir, Philip J. Blower

Publikováno v: Cusnir, R, Cakebread, A, Cooper, M S, Young, J, Blower, P J & Ma, M T 2019, ' The effects of trace metal impurities on Ga-68-radiolabelling with a tris(3-hydroxy-1,6-dimethylpyridin-4-one) (THP) chelator ', RSC Advances, vol. 9, no. 64, pp. 37214-37221 . https://doi.org/10.1039/C9RA07723E

GMP-grade 68Ge/ 68Ga generators provide access to positron-emitting 68Ga, enabling preparation of Positron Emission Tomography (PET) tracers and PET imaging at sites that do not have access to cyclotron-produced radionuclides. Radiotracers based on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7769593e50177446a29745b83a87cf7b
https://kclpure.kcl.ac.uk/ws/files/123486187/The_effects_of_trace_CUSNIR_Accepted25October2019_Published14November2019_GOLD_VoR_CC_BY_.pdf

The Radiopharmaceutical Chemistry of the Radionuclides of Gallium and Indium

Autor: Maggie S. Cooper, Michelle T. Ma, Jennifer D. Young, Julia E. Blower, Philip J. Blower, Cinzia Imberti, Christopher Marshall

Publikováno v: Radiopharmaceutical Chemistry ISBN: 9783319989464

Gallium-68, and indium-111 share the same group in the periodic table and can be harnessed for a range of applications in nuclear medicine, including scintigraphy, SPECT, PET and targeted radiotherapy. Indium-111 and gallium-67 are gamma-emitting rad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfe787e7a8a1ce85cc07e5304dac1d61
https://doi.org/10.1007/978-3-319-98947-1_14