Výsledky vyhledávání - "Jennifer Casserd"

Phase I study of autologous transgenic T cells expressing high affinity mesothelin-specific T-cell receptor (TCR; FH-TCR TMSLN) in patients with metastatic pancreatic ductal adenocarcinoma (mPDA)

Autor: E. Gabriela Chiorean, Aude Chapuis, Andrew L. Coveler, Cecilia CS Yeung, Ted Gooley, David Bing Zhen, Gentry Teng King, Lindsay Marie Hannan, Stacey A. Cohen, Rachael A Safyan, Anthony Germani, Susan Ra, Jennifer Casserd, Thomas Schmitt, Philip D Greenberg

Publikováno v: Journal of Clinical Oncology. 41:TPS779-TPS779

TPS779 Background: PDA has a low tumor mutational burden and an immunosuppressive microenvironment. Targeting overexpressed self-antigens with adoptive, genetically engineered, high affinity T cells may overcome immunosuppression (Stromnes I, Immunol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a42a731ca5e89decbfcf87adec003bf7
https://doi.org/10.1200/jco.2023.41.4_suppl.tps779

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Attamage-A1: Phase I/II study of autologous CD8+ and CD4+ transgenic t cells expressing high affinity MAGE-A1-specific T-cell receptor (TCR) combined with anti-PD(L)1 in patients with metastatic MAGE-A1 expressing cancer

Autor: Michael Thomas Schweizer, Ted Gooley, Sylvia Lee, William R Gwin, Monica Dherin, Megan Hickner, Jennifer Casserd, Megan McAfee, Thomas Schmitt, Cecilia CS Yeung, Vijayakrishna K. Gadi, Aude Chapuis

Publikováno v: Journal of Clinical Oncology. 40:TPS592-TPS592

TPS592 Background: Adoptive cellular therapies can lead to durable responses in treatment refractory leukemias and lymphomas; however, these approaches are still in early stage development for metastatic solid tumors. FH-MagIC TCR-T is an autologous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58a209f531833193c4f6aef08c29a4c8
https://doi.org/10.1200/jco.2022.40.6_suppl.tps592

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