Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jennifer C. Reid"'
Autor:
Deanna P. Porras, Jennifer C. Reid, Borko Tanasijevic, Diana Golubeva, Allison L. Boyd, Mickie Bhatia
Publikováno v:
Cells, Vol 11, Iss 12, p 1915 (2022)
The generation of human hematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) represents a major goal in regenerative medicine and is believed would follow principles of early development. HSCs arise from a type of endothelial cel
Externí odkaz:
https://doaj.org/article/19f4c3de54d34c008ebcff23688ec3d4
Autor:
Luca Orlando, Borko Tanasijevic, Mio Nakanishi, Jennifer C. Reid, Juan L. García-Rodríguez, Kapil Dev Chauhan, Deanna P. Porras, Lili Aslostovar, Justin D. Lu, Zoya Shapovalova, Ryan R. Mitchell, Allison L. Boyd, Mickie Bhatia
Publikováno v:
Cell Reports, Vol 34, Iss 10, Pp 108818- (2021)
Summary: Histone variants (HVs) are a subfamily of epigenetic regulators implicated in embryonic development, but their role in human stem cell fate remains unclear. Here, we reveal that the phosphorylation state of the HV H2A.X (γH2A.X) regulates s
Externí odkaz:
https://doaj.org/article/4557e53b20234f89a0c512ca3d13ed30
Autor:
Jennifer C. Reid, Borko Tanasijevic, Diana Golubeva, Allison L. Boyd, Deanna P. Porras, Tony J. Collins, Mickie Bhatia
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1625-1641 (2018)
Summary: Human pluripotent stem cells (hPSCs) generate hematopoietic progenitor cells (HPCs) but fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) from donors. Recent progress to derive hPSC-derived HSCs ha
Externí odkaz:
https://doaj.org/article/ccabb1b5765542a4a5b34f9e544c110d
Autor:
Diana Golubeva, Deanna P Porras, Meaghan Doyle, Jennifer C Reid, Borko Tanasijevic, Allison L Boyd, Kinga Vojnits, Amro Elrafie, Amy Qiao, Mickie Bhatia
Publikováno v:
Stem Cells Translational Medicine.
Screening of primary patient acute myeloid leukemia (AML) cells is challenging based on intrinsic characteristics of human AML disease and patient-specific conditions required to sustain AML cells in culture. This is further complicated by inter- and
Publikováno v:
Drug discovery today. 27(12)
The discovery and development of effective drugs for cancer patients has seen limited success in the clinic from phase I trials onward. The high attrition rate of current drug development approaches requires careful evaluation to provide a better und
Autor:
Antonino Neri, Fortunato Morabito, Jennifer C. Reid, Luca Orlando, Giovanna Cutrona, Andrew Leber, Mickie Bhatia, Massimo Gentile, Charisa Henly, Cameron G. Hollands, Josée Hébert, Diana Golubeva, Luca Agnelli, Brian Leber, Allison L. Boyd, Manlio Ferrarini
Publikováno v:
Cell reports. 34(11)
Identifying precise targets of individual cancers remains challenging. Chronic lymphocytic leukemia (CLL) represents the most common adult hematologic malignancy, and trisomy 12 (tri12) represents a quarter of CLL patients. We report that tri12 human
Autor:
Mickie Bhatia, Allison L. Boyd, Jennifer C. Reid, Tony J. Collins, Deanna P. Porras, Borko Tanasijevic, Diana Golubeva
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 5, Pp 1625-1641 (2018)
Stem Cell Reports, Vol 10, Iss 5, Pp 1625-1641 (2018)
Summary Human pluripotent stem cells (hPSCs) generate hematopoietic progenitor cells (HPCs) but fail to engraft xenograft models used to detect adult/somatic hematopoietic stem cells (HSCs) from donors. Recent progress to derive hPSC-derived HSCs has
Autor:
Ronan Foley, Mitchell Sabloff, Mickie Bhatia, Jennifer C. Reid, Lili Aslostovar, Yannick D. Benoit, Mio Nakanishi, Brian Leber, Clinton J. V. Campbell, Michael F. Jackson, Anargyros Xenocostas, Mohammed Almakadi, Allison L. Boyd, Deanna P. Porras, Kyle R. Salci, Zoya Shapovalova, Catherine A. Ross, Tony J. Collins, David S. Allan
Publikováno v:
Nature cell biology. 19(11)
Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding of
Autor:
Mickie Bhatia, Borko Tanasijevic, Kyle R. Salci, Luca Orlando, Jennifer C. Reid, Jong-Hee Lee, Zoya Shapovalova
Publikováno v:
Stem cells (Dayton, Ohio). 35(9)
Induced pluripotent stem cell reprogramming has provided critical insights into disease processes by modeling the genetics and related clinical pathophysiology. Human cancer represents highly diverse genetics, as well as inter- and intra-patient hete
Autor:
Mickie Bhatia, Tony J. Collins, Kathryn C. Davidson, Kenichi Shimada, Yannick D. Benoit, Zoya Shapovalova, Jennifer C. Reid, Luca Orlando, Mio Nakanishi, Andras Nagy, Ryan R. Mitchell
Publikováno v:
Cell. 177:910-924.e22
Summary The assembly of organized colonies is the earliest manifestation in the derivation or induction of pluripotency in vitro. However, the necessity and origin of this assemblance is unknown. Here, we identify human pluripotent founder cells (hPF