Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jennifer C. Rea"'
Autor:
Shrirang V. Ranade, Mark R. Wieland, Tammy Tam, Jennifer C. Rea, Judit Horvath, Aaron R. Hieb, Weitao Jia, Lori Grace, Giulio Barteselli, Jay M. Stewart
Publikováno v:
Drug Delivery, Vol 29, Iss 1, Pp 1326-1334 (2022)
The Port Delivery System with ranibizumab (PDS) is an innovative intraocular drug delivery system designed for the continuous delivery of ranibizumab into the vitreous for 6 months and beyond. The PDS includes an ocular implant, a customized formulat
Externí odkaz:
https://doaj.org/article/28e8950e7cf747c48df86516bf005aaa
Autor:
Jennifer C. Rea, Vivek Kumar Garripelli, Robert F. Kelley, Karthikan Rajagopal, Debby P. Chang
Publikováno v:
Journal of Pharmaceutical Sciences. 104:3404-3417
Achieving long-term drug release from polymer-based delivery systems continues to be a challenge particularly for the delivery of large hydrophilic molecules such as therapeutic antibodies and proteins. Here, we report on the utility of an in situ-fo
Autor:
Jennifer Lin, Rinki Kapoor, Annelise E. Barron, Maruti K. Didwania, Christopher H. Contag, Nathaniel P. Chongsiriwatana, Jennifer C. Rea, Modi Wetzler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Many organisms rely on antimicrobial peptides (AMPs) as a first line of defense against pathogens. In general, most AMPs are thought to kill bacteria by binding to and disrupting cell membranes. However, certain AMPs instead appear to inhibit biomacr
Autor:
Yajun Jennifer Wang, Joel Cuzzi, Jennifer C. Rea, Dell Farnan, Isabella de Jong, Yun Lou, Yuhua Hu
Publikováno v:
Journal of Chromatography A. 1270:111-117
Recombinant antigen-binding fragments (Fabs) are currently on the market and in development for the treatment of ophthalmologic indications. Recently, Quality by Design (QbD) initiatives have been implemented that emphasize understanding the relation
Publikováno v:
Biotechnology and Bioengineering. 102:1679-1691
Non-viral gene delivery by immobilization of complexes to cell-adhesive biomaterials, a process termed substrate-mediated delivery, has many in vitro research applications such as transfected cell arrays or models of tissue growth. In this report, we
Publikováno v:
Journal of Pharmaceutical Sciences. 97:4794-4806
Peptides can potentiate lipid-mediated gene delivery by modifying lipoplex physiochemical properties to overcome rate-limiting steps to gene transfer. The objectives of this study were to determine the regimes over which cationic peptides enhance lip
Publikováno v:
The Journal of Gene Medicine. 9:668-678
Gene delivery by non-specific adsorption of non-viral vectors to protein-coated surfaces can reduce the amount of DNA required, and also increase transgene expression and the number of cells expressing the transgene. The protein on the surface mediat
Publikováno v:
Journal of chromatography. A. 1424
Ion-exchange chromatography (IEC) is widely used for profiling the charge heterogeneity of proteins, including monoclonal antibodies (mAbs). Despite good resolving power and robustness, ionic strength-based ion-exchange separations are generally prod
Publikováno v:
Biomaterials. 27:947-954
Gene delivery has numerous potential applications both clinically and for basic science research. Non-viral vectors represent the long-term future of gene therapy and biomaterials are a critical component for the development of efficient delivery sys
Publikováno v:
Ultra-High Performance Liquid Chromatography and its Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd289c14b8be6087045b429b397f996
https://doi.org/10.1002/9781118533956.ch8
https://doi.org/10.1002/9781118533956.ch8