Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Jennifer C. Moore"'
Publikováno v:
Stem Cell Research, Vol 47, Iss , Pp 101926- (2020)
We have generated two iPSC lines from skin biopsies of two healthy individuals. Skin fibroblasts were derived and reprogrammed using a Sendai virus-based approach. The resulting iPSC lines have normal karyotype, express stemness markers and can gener
Externí odkaz:
https://doaj.org/article/a7fd3b382c50420ab5c80efe1de5e1e1
Autor:
Aaron L. Carlson, Neal K. Bennett, Nicola L. Francis, Apoorva Halikere, Stephen Clarke, Jennifer C. Moore, Ronald P. Hart, Kenneth Paradiso, Marius Wernig, Joachim Kohn, Zhiping P. Pang, Prabhas V. Moghe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Human pluripotent stem cell derived neurons have the potential for cell replacement therapy for brain injury and disease but problems on transplantation need to be overcome. Here, the authors use a microtopographic scaffold to graft neurons into both
Externí odkaz:
https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c12
Autor:
Lucy Lin, Mavis R. Swerdel, Michael P. Lazaropoulos, Gary S. Hoffman, Alana J. Toro-Ramos, Jennifer Wright, Howard Lederman, Jianmin Chen, Jennifer C. Moore, Ronald P. Hart
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1097-1108 (2015)
A spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP ana
Externí odkaz:
https://doaj.org/article/94721fb9df1c44888e21a588cc88d000
Autor:
Heather McGowan, Vincent R. Mirabella, Aula Hamod, Aziz Karakhanyan, Nicole Mlynaryk, Jennifer C. Moore, Jay A. Tischfield, Ronald P. Hart, Zhiping P. Pang
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 10 (2018)
Non-coding RNA, including microRNA (miRNA) serves critical regulatory functions in the developing brain. The let-7 family of miRNAs has been shown to regulate neuronal differentiation, neural subtype specification, and synapse formation in animal mod
Externí odkaz:
https://doaj.org/article/76ab7ffd7940456480c2b11fdad298d2
Autor:
Martin Sauvageau, Loyal A Goff, Simona Lodato, Boyan Bonev, Abigail F Groff, Chiara Gerhardinger, Diana B Sanchez-Gomez, Ezgi Hacisuleyman, Eric Li, Matthew Spence, Stephen C Liapis, William Mallard, Michael Morse, Mavis R Swerdel, Michael F D’Ecclessis, Jennifer C Moore, Venus Lai, Guochun Gong, George D Yancopoulos, David Frendewey, Manolis Kellis, Ronald P Hart, David M Valenzuela, Paola Arlotta, John L Rinn
Publikováno v:
eLife, Vol 2 (2013)
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological cond
Externí odkaz:
https://doaj.org/article/5fdb35f4c02f45c69bc508db25a26cb3
Publikováno v:
Stem Cell Research, Vol 47, Iss, Pp 101926-(2020)
We have generated two iPSC lines from skin biopsies of two healthy individuals. Skin fibroblasts were derived and reprogrammed using a Sendai virus-based approach. The resulting iPSC lines have normal karyotype, express stemness markers and can gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32498ead332b22dc1268be05c715788b
https://pubmed.ncbi.nlm.nih.gov/32738631
https://pubmed.ncbi.nlm.nih.gov/32738631
Autor:
Roy V. Sillitoe, Anna Taylor, Jerrold L. Vitek, Mark Hallett, Kristina Simonyan, Sarah Pirio Richardson, Laurie J. Ozelius, Nutan Sharma, Beth Anne Sieber, Laura B. Scheinfeldt, Codrin Lungu, David G. Standaert, Brian Berman, Philip A. Starr, Christine Swanson-Fisher, Rachel Saunders-Pullman, Jennifer C. Moore, Nicole Calakos, Joel S. Perlmutter
Publikováno v:
Neurology
ObjectiveDystonia is a complex movement disorder. Research progress has been difficult, particularly in developing widely effective therapies. This is a review of the current state of knowledge, research gaps, and proposed research priorities.Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db967d7e5f22873a442e1d3409ddfd7
https://europepmc.org/articles/PMC7274927/
https://europepmc.org/articles/PMC7274927/
Autor:
Mavis R. Swerdel, Zhiping P. Pang, Jay A. Tischfield, Matthew S. Scarnati, Jennifer C. Moore, Ronald P. Hart, Apoorva Halikere, Aula Hamod, Dina Popova
Publikováno v:
Molecular psychiatry
The OPRM1 A118G single nucleotide polymorphism (SNP rs1799971) gene variant encoding the N40D µ-opioid receptor (MOR) has been associated with dependence on opiates and other drugs of abuse but its mechanism is unknown. The frequency of G-allele car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb3f90ea489231ea947b25c22c0f9fa
https://pubmed.ncbi.nlm.nih.gov/31481756
https://pubmed.ncbi.nlm.nih.gov/31481756
Autor:
Atul K. Bhattiprolu, Linda M. Brzustowicz, Christen Crosta, Allen Y. Fu, Stephen G. Clarke, Kristina Hernandez, Kenneth G Paradiso, Bonnie L. Firestein, Natasha R. Dudzinski, Jennifer C. Moore
Publikováno v:
Mol Cell Neurosci
Abnormal dendritic arbor development has been implicated in a number of neurodevelopmental disorders, such as autism and Rett syndrome, and the neuropsychiatric disorder schizophrenia. Postmortem brain samples from subjects with schizophrenia show el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de695feffc6c10e1512836317ee8a12
https://doi.org/10.1016/j.mcn.2020.103562
https://doi.org/10.1016/j.mcn.2020.103562
Autor:
Joachim Kohn, Ronald P. Hart, Kenneth G Paradiso, Prabhas V. Moghe, Neal K. Bennett, Marius Wernig, Zhiping P. Pang, Jennifer C. Moore, Stephen G. Clarke, Nicola L. Francis, Aaron L. Carlson, Apoorva Halikere
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
Cell replacement therapy with human pluripotent stem cell-derived neurons has the potential to ameliorate neurodegenerative dysfunction and central nervous system injuries, but reprogrammed neurons are dissociated and spatially disorganized during tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8ae35734b22e38ff780e706b8d7baf
https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c12
https://doaj.org/article/1cdbd92bc9c24daca3285c1be2d05c12